Difference between revisions of "Blood work"
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! Key blood work | ! Key blood work | ||
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|[[Primary biliary | |[[Primary biliary cholangitis]] | ||
|AMA +ve<ref name=pmid20955967>{{Cite journal | last1 = Nguyen | first1 = DL. | last2 = Juran | first2 = BD. | last3 = Lazaridis | first3 = KN. | title = Primary biliary cirrhosis. | journal = Best Pract Res Clin Gastroenterol | volume = 24 | issue = 5 | pages = 647-54 | month = Oct | year = 2010 | doi = 10.1016/j.bpg.2010.07.006 | PMID = 20955967 }}</ref> | |AMA +ve<ref name=pmid20955967>{{Cite journal | last1 = Nguyen | first1 = DL. | last2 = Juran | first2 = BD. | last3 = Lazaridis | first3 = KN. | title = Primary biliary cirrhosis. | journal = Best Pract Res Clin Gastroenterol | volume = 24 | issue = 5 | pages = 647-54 | month = Oct | year = 2010 | doi = 10.1016/j.bpg.2010.07.006 | PMID = 20955967 }}</ref> | ||
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| [[Systemic lupus erythematosus]] | | [[Systemic lupus erythematosus]] | ||
| ANA +ve, anti-dsDNA, Anti-Sm | | ANA +ve, anti-dsDNA +ve, Anti-Sm +ve | ||
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| [[Sjögren syndrome]] | | [[Sjögren syndrome]] | ||
| Anti-SS-A/Ro, Anti-SS-B/La<ref name=pmid19323360>{{Cite journal | title = Information from your family doctor. Sjögren syndrome. | journal = Am Fam Physician | volume = 79 | issue = 6 | pages = 472 | month = Mar | year = 2009 | doi = | PMID = 19323360 | URL = http://www.aafp.org/afp/2009/0315/p465.html }}</ref> | | Anti-SS-A/Ro +ve, Anti-SS-B/La +ve, ANA +ve<ref name=pmid19323360>{{Cite journal | title = Information from your family doctor. Sjögren syndrome. | journal = Am Fam Physician | volume = 79 | issue = 6 | pages = 472 | month = Mar | year = 2009 | doi = | PMID = 19323360 | URL = http://www.aafp.org/afp/2009/0315/p465.html }}</ref> | ||
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| [[Scleroderma]] | | [[Scleroderma]] | ||
| | | Anti-topoisomerase (ATA), Anti-centromere (ACA), anti-Scl-70 (type of ATA) | ||
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| [[Mixed connective tissue disease]] | | [[Mixed connective tissue disease]] | ||
| | | anti-U1-RNP (ribonucleoprotein) +ve,<ref name=pmid20722023>{{Cite journal | last1 = Sato | first1 = T. | last2 = Fujii | first2 = T. | last3 = Yokoyama | first3 = T. | last4 = Fujita | first4 = Y. | last5 = Imura | first5 = Y. | last6 = Yukawa | first6 = N. | last7 = Kawabata | first7 = D. | last8 = Nojima | first8 = T. | last9 = Ohmura | first9 = K. | title = Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease. | journal = Arthritis Rheum | volume = 62 | issue = 12 | pages = 3730-40 | month = Dec | year = 2010 | doi = 10.1002/art.27700 | PMID = 20722023 }}</ref> ANA +ve (speckled) | ||
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| Pathology | | Pathology | ||
Latest revision as of 20:59, 30 September 2021
This article takes a superficial look at blood work. Blood work is often essential definitively diagnostic.
In many medical diseases, it is an essential component and should be considered by the pathologist; thus, it is important to be familiar with common blood tests.
Pathology & blood work
| Pathology | Key blood work |
|---|---|
| Primary biliary cholangitis | AMA +ve[1] |
| Autoimmune hepatitis | ANA +ve, LKM-1 +ve, SMA +ve, IgG high[2] |
| Celiac disease | Anti-tissue transglutaminase +ve, anti-endomysial +ve, IgA deficiency |
| Systemic lupus erythematosus | ANA +ve, anti-dsDNA +ve, Anti-Sm +ve |
| Sjögren syndrome | Anti-SS-A/Ro +ve, Anti-SS-B/La +ve, ANA +ve[3] |
| Scleroderma | Anti-topoisomerase (ATA), Anti-centromere (ACA), anti-Scl-70 (type of ATA) |
| Mixed connective tissue disease | anti-U1-RNP (ribonucleoprotein) +ve,[4] ANA +ve (speckled) |
See also
References
- ↑ Nguyen, DL.; Juran, BD.; Lazaridis, KN. (Oct 2010). "Primary biliary cirrhosis.". Best Pract Res Clin Gastroenterol 24 (5): 647-54. doi:10.1016/j.bpg.2010.07.006. PMID 20955967.
- ↑ Scoring systems for the diagnosis of autoimmune hepatitis: past, present, and future. Wiegard C, Schramm C, Lohse AW. Semin Liver Dis. 2009 Aug;29(3):254-61. Epub 2009 Aug 12. PMID 19675998
- ↑ "Information from your family doctor. Sjögren syndrome.". Am Fam Physician 79 (6): 472. Mar 2009. PMID 19323360.
- ↑ Sato, T.; Fujii, T.; Yokoyama, T.; Fujita, Y.; Imura, Y.; Yukawa, N.; Kawabata, D.; Nojima, T. et al. (Dec 2010). "Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.". Arthritis Rheum 62 (12): 3730-40. doi:10.1002/art.27700. PMID 20722023.