Difference between revisions of "Tissue floater"
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A '''tissue floater''', also '''floater''', is a (biologic) contaminant that is transferred to the slide some time during [[tissue processing]].<ref name=pmid19492892>{{Cite journal | last1 = Platt | first1 = E. | last2 = Sommer | first2 = P. | last3 = McDonald | first3 = L. | last4 = Bennett | first4 = A. | last5 = Hunt | first5 = J. | title = Tissue floaters and contaminants in the histology laboratory. | journal = Arch Pathol Lab Med | volume = 133 | issue = 6 | pages = 973-8 | month = Jun | year = 2009 | doi = 10.1043/1543-2165-133.6.973 | PMID = 19492892 | URL = http://www.archivesofpathology.org/doi/full/10.1043/1543-2165-133.6.973}}</ref> | A '''tissue floater''', also '''floater''', is a (biologic) contaminant that is transferred to the slide some time during [[tissue processing]].<ref name=pmid19492892>{{Cite journal | last1 = Platt | first1 = E. | last2 = Sommer | first2 = P. | last3 = McDonald | first3 = L. | last4 = Bennett | first4 = A. | last5 = Hunt | first5 = J. | title = Tissue floaters and contaminants in the histology laboratory. | journal = Arch Pathol Lab Med | volume = 133 | issue = 6 | pages = 973-8 | month = Jun | year = 2009 | doi = 10.1043/1543-2165-133.6.973 | PMID = 19492892 | URL = http://www.archivesofpathology.org/doi/full/10.1043/1543-2165-133.6.973}}</ref> | ||
A floater is a type of ''extraneous tissue'' and foreign to the case.<ref name=pmid22031316>{{Cite journal | last1 = Layfield | first1 = LJ. | last2 = Witt | first2 = BL. | last3 = Metzger | first3 = KG. | last4 = Anderson | first4 = GM. | title = Extraneous tissue: a potential source for diagnostic error in surgical pathology. | journal = Am J Clin Pathol | volume = 136 | issue = 5 | pages = 767-72 | month = Nov | year = 2011 | doi = 10.1309/AJCP4FFSBPHAU8IU | PMID = 22031316 | URL = http://ajcp.ascpjournals.org/content/136/5/767.long }}</ref><ref name=pmid12049100>{{Cite journal | last1 = Gephardt | first1 = GN. | last2 = Zarbo | first2 = RJ. | title = Extraneous tissue in surgical pathology: a College of American Pathologists Q-Probes study of 275 laboratories. | journal = Arch Pathol Lab Med | volume = 120 | issue = 11 | pages = 1009-14 | month = Nov | year = 1996 | doi = | PMID = 12049100 }}</ref> They are ''not'' found in the tissue block.<ref name=pmid22031316/> Contaminants in the tissue block, i.e. paraffin block, are known as "pick-up" and, generally, are assumed to result from conditions at the grossing bench. | A floater is a type of ''extraneous tissue'' and foreign to the case.<ref name=pmid22031316>{{Cite journal | last1 = Layfield | first1 = LJ. | last2 = Witt | first2 = BL. | last3 = Metzger | first3 = KG. | last4 = Anderson | first4 = GM. | title = Extraneous tissue: a potential source for diagnostic error in surgical pathology. | journal = Am J Clin Pathol | volume = 136 | issue = 5 | pages = 767-72 | month = Nov | year = 2011 | doi = 10.1309/AJCP4FFSBPHAU8IU | PMID = 22031316 | URL = http://ajcp.ascpjournals.org/content/136/5/767.long }}</ref><ref name=pmid12049100>{{Cite journal | last1 = Gephardt | first1 = GN. | last2 = Zarbo | first2 = RJ. | title = Extraneous tissue in surgical pathology: a College of American Pathologists Q-Probes study of 275 laboratories. | journal = Arch Pathol Lab Med | volume = 120 | issue = 11 | pages = 1009-14 | month = Nov | year = 1996 | doi = | PMID = 12049100 }}</ref> They are ''not'' found in the tissue block.<ref name=pmid22031316/> Contaminants in the tissue block, i.e. paraffin block, are known as "pick-up" and, generally, are assumed to result from conditions at the [[cut-up|grossing]] bench. | ||
==Quality== | ==Quality== | ||
| Line 8: | Line 8: | ||
==Management== | ==Management== | ||
*Tissue that cannot be definitely identified as a floater may require identity testing, using short tanden repeat (STR) DNA testing.<ref name=pmid19745614>{{Cite journal | last1 = Mosse | first1 = CA. | last2 = Stumph | first2 = JR. | last3 = Best | first3 = DH. | last4 = Vnencak-Jones | first4 = CL. | title = A B-cell lymphoma diagnosed in floater tissue: implications of the diagnosis and resolution of a laboratory error. | journal = Am J Med Sci | volume = 338 | issue = 3 | pages = 248-51 | month = Sep | year = 2009 | doi = 10.1097/MAJ.0b013e3181a88dc0 | PMID = 19745614 }}</ref> | *Tissue that is confidently identified as a floater and benign is typically identified as such on the slide and otherwise ignored. | ||
**Example: a fragment of benign colon on an endometrial biopsy seen only on one level. | |||
*Tissue that cannot be definitely identified as a floater may require [[identity testing]], using short tanden repeat (STR) DNA testing.<ref name=pmid19745614>{{Cite journal | last1 = Mosse | first1 = CA. | last2 = Stumph | first2 = JR. | last3 = Best | first3 = DH. | last4 = Vnencak-Jones | first4 = CL. | title = A B-cell lymphoma diagnosed in floater tissue: implications of the diagnosis and resolution of a laboratory error. | journal = Am J Med Sci | volume = 338 | issue = 3 | pages = 248-51 | month = Sep | year = 2009 | doi = 10.1097/MAJ.0b013e3181a88dc0 | PMID = 19745614 }}</ref> | |||
*Malignant tissue that is apparently foreign to the case should be worked-up and reported. | |||
==See also== | ==See also== | ||
*[[Molecular pathology tests]]. | *[[Molecular pathology tests]]. | ||
*[[Quality]]. | *[[Quality]]. | ||
*[[Lost tissue]]. | |||
==References== | ==References== | ||
Latest revision as of 18:34, 15 January 2015
A tissue floater, also floater, is a (biologic) contaminant that is transferred to the slide some time during tissue processing.[1]
A floater is a type of extraneous tissue and foreign to the case.[2][3] They are not found in the tissue block.[2] Contaminants in the tissue block, i.e. paraffin block, are known as "pick-up" and, generally, are assumed to result from conditions at the grossing bench.
Quality
Main article: Quality
Floaters are considered to be near-misses, as they can lead to misdiagnoses if not identified as such.[4] They are considered to be an indicator of (poor) quality.
Management
- Tissue that is confidently identified as a floater and benign is typically identified as such on the slide and otherwise ignored.
- Example: a fragment of benign colon on an endometrial biopsy seen only on one level.
- Tissue that cannot be definitely identified as a floater may require identity testing, using short tanden repeat (STR) DNA testing.[5]
- Malignant tissue that is apparently foreign to the case should be worked-up and reported.
See also
References
- ↑ Platt, E.; Sommer, P.; McDonald, L.; Bennett, A.; Hunt, J. (Jun 2009). "Tissue floaters and contaminants in the histology laboratory.". Arch Pathol Lab Med 133 (6): 973-8. doi:10.1043/1543-2165-133.6.973. PMID 19492892.
- ↑ 2.0 2.1 Layfield, LJ.; Witt, BL.; Metzger, KG.; Anderson, GM. (Nov 2011). "Extraneous tissue: a potential source for diagnostic error in surgical pathology.". Am J Clin Pathol 136 (5): 767-72. doi:10.1309/AJCP4FFSBPHAU8IU. PMID 22031316.
- ↑ Gephardt, GN.; Zarbo, RJ. (Nov 1996). "Extraneous tissue in surgical pathology: a College of American Pathologists Q-Probes study of 275 laboratories.". Arch Pathol Lab Med 120 (11): 1009-14. PMID 12049100.
- ↑ Smith, ML.; Raab, SS. (Nov 2011). "Assessment of latent factors contributing to error: addressing surgical pathology error wisely.". Arch Pathol Lab Med 135 (11): 1436-40. doi:10.5858/arpa.2011-0334-OA. PMID 22032570.
- ↑ Mosse, CA.; Stumph, JR.; Best, DH.; Vnencak-Jones, CL. (Sep 2009). "A B-cell lymphoma diagnosed in floater tissue: implications of the diagnosis and resolution of a laboratory error.". Am J Med Sci 338 (3): 248-51. doi:10.1097/MAJ.0b013e3181a88dc0. PMID 19745614.