Difference between revisions of "Female adnexal tumour of probable Wolffian origin"

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#redirect [[Gynecologic_pathology#Female_adnexal_tumour_of_probable_Wolffian_origin]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Female adnexal tumour of probable Wolffian origin - very high mag.jpg
| Width      =
| Caption    = FATWO. [[H&E stain]].
| Micro      =
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        = vimentin +ve, AE1/AE3 +ve, CAM5.2 +ve, AR +ve (~80% of cases)
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = adnexa ([[ovary]])
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = usu. benign
| Other      =
| ClinDDx    =
}}
'''Female adnexal tumour of probable Wolffian origin''', abbreviated '''FATWO''', is a rare usually benign tumour.
 
It is also known as '''Wolffian adnexal tumour''', abbreviated '''WAT'''.
 
==General==
*Super rare.<ref name=pmid22611973>{{Cite journal  | last1 = Tianmin | first1 = X. | last2 = Weiqim | first2 = C. | last3 = Mianhua | first3 = C. | last4 = Xiaocui | first4 = L. | last5 = Hongwen | first5 = G. | last6 = Min | first6 = Y. | title = Tumor of the mesosalpinx: case report of a female adnexal tumor of probable Wolffian origin. | journal = Eur J Gynaecol Oncol | volume = 33 | issue = 2 | pages = 233-5 | month =  | year = 2012 | doi =  | PMID = 22611973 }}</ref>
*Usually benign.
**May be malignant.<ref name=pmid21542539>{{Cite journal  | last1 = Heller | first1 = DS. | last2 = Kadire | first2 = B. | last3 = Cracchiolo | first3 = B. | title = Malignant female adnexal tumor of probable Wolffian origin: a case report. | journal = J Reprod Med | volume = 56 | issue = 3-4 | pages = 175-7 | month =  | year =  | doi =  | PMID = 21542539 }}</ref>
 
==Gross==
Adnexal location - as the name suggests:<ref name=pmid10414506/>
*Broad ligament of ovary.
*Mesosalpinx.
*Ovarian hilus - less common.
 
==Microscopic==
Features:<ref name=pmid10414506/>
*Variable architecture:
**Tubular or glandular.
**Solid - spindle cells.
**Multicystic.
 
DDx:
*[[Brenner tumour]].
 
===Images===
<gallery>
Image: Female adnexal tumour of probable Wolffian origin - intermed mag.jpg | FATWO - intermed. mag.
Image: Female adnexal tumour of probable Wolffian origin - high mag.jpg | FATWO - high mag.
Image: Female adnexal tumour of probable Wolffian origin - very high mag.jpg | FATWO - very high mag.
</gallery>
 
==IHC==
Features:<ref name=pmid10414506>{{Cite journal  | last1 = Devouassoux-Shisheboran | first1 = M. | last2 = Silver | first2 = SA. | last3 = Tavassoli | first3 = FA. | title = Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin. | journal = Hum Pathol | volume = 30 | issue = 7 | pages = 856-63 | month = Jul | year = 1999 | doi =  | PMID = 10414506 }}</ref>
*Vimentin +ve.
*AE1/AE3 +ve.
*CAM5.2 +ve.
*CK7 +ve -- focal, sometimes -ve.
*AR +ve ~80% of cases.
*Inhibin +ve ~70% of cases.
 
Others:<ref name=pmid10414506/>
*CK20 -ve.
*mCEA -ve.
 
==See also==
*[[Gynecologic pathology]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Gynecologic pathology]]

Latest revision as of 03:23, 23 April 2015

Female adnexal tumour of probable Wolffian origin
Diagnosis in short

FATWO. H&E stain.
IHC vimentin +ve, AE1/AE3 +ve, CAM5.2 +ve, AR +ve (~80% of cases)
Site adnexa (ovary)
Prevalence very rare
Prognosis usu. benign

Female adnexal tumour of probable Wolffian origin, abbreviated FATWO, is a rare usually benign tumour.

It is also known as Wolffian adnexal tumour, abbreviated WAT.

General

  • Super rare.[1]
  • Usually benign.
    • May be malignant.[2]

Gross

Adnexal location - as the name suggests:[3]

  • Broad ligament of ovary.
  • Mesosalpinx.
  • Ovarian hilus - less common.

Microscopic

Features:[3]

  • Variable architecture:
    • Tubular or glandular.
    • Solid - spindle cells.
    • Multicystic.

DDx:

Images

  • FATWO - intermed. mag.

  • FATWO - high mag.

  • FATWO - very high mag.

IHC

Features:[3]

  • Vimentin +ve.
  • AE1/AE3 +ve.
  • CAM5.2 +ve.
  • CK7 +ve -- focal, sometimes -ve.
  • AR +ve ~80% of cases.
  • Inhibin +ve ~70% of cases.

Others:[3]

  • CK20 -ve.
  • mCEA -ve.

See also

References

  1. ↑ Tianmin, X.; Weiqim, C.; Mianhua, C.; Xiaocui, L.; Hongwen, G.; Min, Y. (2012). "Tumor of the mesosalpinx: case report of a female adnexal tumor of probable Wolffian origin.". Eur J Gynaecol Oncol 33 (2): 233-5. PMID 22611973.
  2. ↑ Heller, DS.; Kadire, B.; Cracchiolo, B.. "Malignant female adnexal tumor of probable Wolffian origin: a case report.". J Reprod Med 56 (3-4): 175-7. PMID 21542539.
  3. ↑ 3.0 3.1 3.2 3.3 Devouassoux-Shisheboran, M.; Silver, SA.; Tavassoli, FA. (Jul 1999). "Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin.". Hum Pathol 30 (7): 856-63. PMID 10414506.
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