Difference between revisions of "Female adnexal tumour of probable Wolffian origin"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Female adnexal tumour of probable Wolffian origin - very high mag.jpg | |||
| Width = | |||
| Caption = FATWO. [[H&E stain]]. | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = vimentin +ve, AE1/AE3 +ve, CAM5.2 +ve, AR +ve (~80% of cases) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = adnexa ([[ovary]]) | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usu. benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Female adnexal tumour of probable Wolffian origin''', abbreviated '''FATWO''', is a rare usually benign tumour. | '''Female adnexal tumour of probable Wolffian origin''', abbreviated '''FATWO''', is a rare usually benign tumour. | ||
It is also known as '''Wolffian adnexal tumour'''. | It is also known as '''Wolffian adnexal tumour''', abbreviated '''WAT'''. | ||
==General== | ==General== | ||
*Super rare.<ref name=pmid22611973>{{Cite journal | last1 = Tianmin | first1 = X. | last2 = Weiqim | first2 = C. | last3 = Mianhua | first3 = C. | last4 = Xiaocui | first4 = L. | last5 = Hongwen | first5 = G. | last6 = Min | first6 = Y. | title = Tumor of the mesosalpinx: case report of a female adnexal tumor of probable Wolffian origin. | journal = Eur J Gynaecol Oncol | volume = 33 | issue = 2 | pages = 233-5 | month = | year = 2012 | doi = | PMID = 22611973 }}</ref> | *Super rare.<ref name=pmid22611973>{{Cite journal | last1 = Tianmin | first1 = X. | last2 = Weiqim | first2 = C. | last3 = Mianhua | first3 = C. | last4 = Xiaocui | first4 = L. | last5 = Hongwen | first5 = G. | last6 = Min | first6 = Y. | title = Tumor of the mesosalpinx: case report of a female adnexal tumor of probable Wolffian origin. | journal = Eur J Gynaecol Oncol | volume = 33 | issue = 2 | pages = 233-5 | month = | year = 2012 | doi = | PMID = 22611973 }}</ref> | ||
*Usually benign. | *Usually benign. | ||
**May be malignant.<ref name=pmid21542539>{{Cite journal | last1 = Heller | first1 = DS. | last2 = Kadire | first2 = B. | last3 = Cracchiolo | first3 = B. | title = Malignant female adnexal tumor of probable Wolffian origin: a case report. | journal = J Reprod Med | volume = 56 | issue = 3-4 | pages = 175-7 | month = | year = | doi = | PMID = 21542539 }}</ref> | **May be malignant.<ref name=pmid21542539>{{Cite journal | last1 = Heller | first1 = DS. | last2 = Kadire | first2 = B. | last3 = Cracchiolo | first3 = B. | title = Malignant female adnexal tumor of probable Wolffian origin: a case report. | journal = J Reprod Med | volume = 56 | issue = 3-4 | pages = 175-7 | month = | year = | doi = | PMID = 21542539 }}</ref> | ||
==Gross== | |||
Adnexal location - as the name suggests:<ref name=pmid10414506/> | |||
*Broad ligament of ovary. | |||
*Mesosalpinx. | |||
*Ovarian hilus - less common. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid10414506/> | ||
*Tubular | *Variable architecture: | ||
**Tubular or glandular. | |||
**Solid - spindle cells. | |||
**Multicystic. | |||
DDx: | DDx: | ||
| Line 22: | Line 59: | ||
Image: Female adnexal tumour of probable Wolffian origin - very high mag.jpg | FATWO - very high mag. | Image: Female adnexal tumour of probable Wolffian origin - very high mag.jpg | FATWO - very high mag. | ||
</gallery> | </gallery> | ||
==IHC== | |||
Features:<ref name=pmid10414506>{{Cite journal | last1 = Devouassoux-Shisheboran | first1 = M. | last2 = Silver | first2 = SA. | last3 = Tavassoli | first3 = FA. | title = Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin. | journal = Hum Pathol | volume = 30 | issue = 7 | pages = 856-63 | month = Jul | year = 1999 | doi = | PMID = 10414506 }}</ref> | |||
*Vimentin +ve. | |||
*AE1/AE3 +ve. | |||
*CAM5.2 +ve. | |||
*CK7 +ve -- focal, sometimes -ve. | |||
*AR +ve ~80% of cases. | |||
*Inhibin +ve ~70% of cases. | |||
Others:<ref name=pmid10414506/> | |||
*CK20 -ve. | |||
*mCEA -ve. | |||
==See also== | ==See also== | ||
Latest revision as of 03:23, 23 April 2015
| Female adnexal tumour of probable Wolffian origin | |
|---|---|
| Diagnosis in short | |
 FATWO. H&E stain. | |
| IHC | vimentin +ve, AE1/AE3 +ve, CAM5.2 +ve, AR +ve (~80% of cases) |
| Site | adnexa (ovary) |
|
| |
| Prevalence | very rare |
| Prognosis | usu. benign |
Female adnexal tumour of probable Wolffian origin, abbreviated FATWO, is a rare usually benign tumour.
It is also known as Wolffian adnexal tumour, abbreviated WAT.
General
Gross
Adnexal location - as the name suggests:[3]
- Broad ligament of ovary.
- Mesosalpinx.
- Ovarian hilus - less common.
Microscopic
Features:[3]
- Variable architecture:
- Tubular or glandular.
- Solid - spindle cells.
- Multicystic.
DDx:
Images
FATWO - intermed. mag.
FATWO - high mag.
FATWO - very high mag.
IHC
Features:[3]
- Vimentin +ve.
- AE1/AE3 +ve.
- CAM5.2 +ve.
- CK7 +ve -- focal, sometimes -ve.
- AR +ve ~80% of cases.
- Inhibin +ve ~70% of cases.
Others:[3]
- CK20 -ve.
- mCEA -ve.
See also
References
- ↑ Tianmin, X.; Weiqim, C.; Mianhua, C.; Xiaocui, L.; Hongwen, G.; Min, Y. (2012). "Tumor of the mesosalpinx: case report of a female adnexal tumor of probable Wolffian origin.". Eur J Gynaecol Oncol 33 (2): 233-5. PMID 22611973.
- ↑ Heller, DS.; Kadire, B.; Cracchiolo, B.. "Malignant female adnexal tumor of probable Wolffian origin: a case report.". J Reprod Med 56 (3-4): 175-7. PMID 21542539.
- ↑ 3.0 3.1 3.2 3.3 Devouassoux-Shisheboran, M.; Silver, SA.; Tavassoli, FA. (Jul 1999). "Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin.". Hum Pathol 30 (7): 856-63. PMID 10414506.