Difference between revisions of "Perineural invasion"
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[[Image:Prostatic adenocarcinoma with perineural invasion.JPG|thumb|right|300px|Perineural invasion in prostate carcinoma. [[H&E stain]].]] | |||
'''Perineural invasion''', also known as '''perineural tumour''', is the presence of a tumour within the nerve sheath. It is abbreviated as '''PNI'''. | '''Perineural invasion''', also known as '''perineural tumour''', is the presence of a tumour within the nerve sheath. It is abbreviated as '''PNI'''. | ||
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DDx: | DDx: | ||
*Benign perineural glands (known as ''benign perineural involvement'').<ref name=pmid16096404>{{Cite journal | last1 = Ali | first1 = TZ. | last2 = Epstein | first2 = JI. | title = Perineural involvement by benign prostatic glands on needle biopsy. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1159-63 | month = Sep | year = 2005 | doi = | PMID = 16096404 }}</ref> | *Benign perineural glands (known as ''benign perineural involvement'').<ref name=pmid16096404>{{Cite journal | last1 = Ali | first1 = TZ. | last2 = Epstein | first2 = JI. | title = Perineural involvement by benign prostatic glands on needle biopsy. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1159-63 | month = Sep | year = 2005 | doi = | PMID = 16096404 }}</ref> | ||
**Should ''not'' completely wrap around the gland. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Latest revision as of 01:09, 21 April 2015
Perineural invasion in prostate carcinoma. H&E stain.
Perineural invasion, also known as perineural tumour, is the presence of a tumour within the nerve sheath. It is abbreviated as PNI.
Generally, it is an indicator of a poor prognosis.
Specific tumours
| Tumour | Prognosis | Comment |
|---|---|---|
| Colorectal carcinoma | independent predictor[1] |
Microscopic
Features:
- Tumour within the nerve sheath.
DDx:
- Benign perineural glands (known as benign perineural involvement).[2]
- Should not completely wrap around the gland.
Images
Prostate adenocarcinoma with PNI - obvious (WC/Nephron)
Prostate adenocarcinoma with PNI (WC/Nephron)
See also
References
- ↑ Liebig, C.; Ayala, G.; Wilks, J.; Verstovsek, G.; Liu, H.; Agarwal, N.; Berger, DH.; Albo, D. (Nov 2009). "Perineural invasion is an independent predictor of outcome in colorectal cancer.". J Clin Oncol 27 (31): 5131-7. doi:10.1200/JCO.2009.22.4949. PMID 19738119.
- ↑ Ali, TZ.; Epstein, JI. (Sep 2005). "Perineural involvement by benign prostatic glands on needle biopsy.". Am J Surg Pathol 29 (9): 1159-63. PMID 16096404.