Difference between revisions of "Renomedullary interstitial cell tumour"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Renal_medullary_fibroma_-_very_high_mag.jpg
| Width      =
| Caption    = Renal medullary fibroma. [[H&E stain]].
| Synonyms  = renal medullary fibroma
| Micro      = small polygonal/stellate cells in abundant loose/[[myxoid stroma]], +/-entrapped renal tubules
| Subtypes  =
| LMDDx      = renal myxoma, edge of medium-sized blood vessel
| Stains    =
| IHC        = alpha-SMA +ve, CD35 +ve
| EM        =
| Molecular  =
| IF        =
| Gross      = small (usu. <3 mm), white, well-circumscribed nodule - medulla of kidney
| Grossing  =
| Site      = [[kidney]] - see ''[[kidney tumours]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Renomedullary interstitial cell tumour''', also known as '''medullary fibroma''',<ref name=pmid11054036 >{{Cite journal  | last1 = Bircan | first1 = S. | last2 = Orhan | first2 = D. | last3 = Tulunay | first3 = O. | last4 = Safak | first4 = M. | title = Renomedullary interstitial cell tumor. | journal = Urol Int | volume = 65 | issue = 3 | pages = 163-6 | month =  | year = 2000 | doi =  | PMID = 11054036 }}</ref> is a relatively common benign tumour of the kidney.
'''Renomedullary interstitial cell tumour''', also known as '''medullary fibroma''',<ref name=pmid11054036 >{{Cite journal  | last1 = Bircan | first1 = S. | last2 = Orhan | first2 = D. | last3 = Tulunay | first3 = O. | last4 = Safak | first4 = M. | title = Renomedullary interstitial cell tumor. | journal = Urol Int | volume = 65 | issue = 3 | pages = 163-6 | month =  | year = 2000 | doi =  | PMID = 11054036 }}</ref> is a relatively common benign tumour of the kidney.


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*Abundant loose/[[myxoid stroma]].
*Abundant loose/[[myxoid stroma]].
*+/-Entrapped renal tubules.<ref name=pmid12066202>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month =  | year =  | doi =  | PMID = 12066202 }}</ref>
*+/-Entrapped renal tubules.<ref name=pmid12066202>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month =  | year =  | doi =  | PMID = 12066202 }}</ref>
DDx:
*Renal myxoma.<ref name=pmid8291657>{{Cite journal  | last1 = Melamed | first1 = J. | last2 = Reuter | first2 = VE. | last3 = Erlandson | first3 = RA. | last4 = Rosai | first4 = J. | title = Renal myxoma. A report of two cases and review of the literature. | journal = Am J Surg Pathol | volume = 18 | issue = 2 | pages = 187-94 | month = Feb | year = 1994 | doi =  | PMID = 8291657 }}</ref>
*Edge of medium-sized blood vessel.


===Images===
===Images===
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Image:Renal_medullary_fibroma_-_low_mag.jpg | Renal medullary fibroma - low mag. (WC/Nephron)
Image:Renal_medullary_fibroma_-_low_mag.jpg | Renal medullary fibroma - low mag. (WC/Nephron)
Image:Renal_medullary_fibroma_-_intermed_mag.jpg | Renal medullary fibroma - intermed. mag. (WC/Nephron)
Image:Renal_medullary_fibroma_-_intermed_mag.jpg | Renal medullary fibroma - intermed. mag. (WC/Nephron)
Image:Renal_medullary_fibroma_-_high_mag.jpg | Renal medullary fibroma - high mag. (WC/Nephron)
Image:Renal_medullary_fibroma_-_very_high_mag.jpg | Renal medullary fibroma - very high mag. (WC/Nephron)
Image:Renal_medullary_fibroma_-_very_high_mag.jpg | Renal medullary fibroma - very high mag. (WC/Nephron)
</gallery>
</gallery>
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*[http://webpathology.com/image.asp?case=71&n=15 Renomedullary interstitial cell tumour - low mag. (webpathology.com)].
*[http://webpathology.com/image.asp?case=71&n=15 Renomedullary interstitial cell tumour - low mag. (webpathology.com)].
*[http://webpathology.com/image.asp?n=16&Case=71 Renomedullary interstitial cell tumour - high mag. (webpathology.com)].
*[http://webpathology.com/image.asp?n=16&Case=71 Renomedullary interstitial cell tumour - high mag. (webpathology.com)].
==IHC==
Features:<ref name=pmid12066202>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Toi | first2 = M. | last3 = Miyazaki | first3 = E. | last4 = Hayashi | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Hiroi | first6 = M. | last7 = Enzan | first7 = H. | title = Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors. | journal = Oncol Rep | volume = 9 | issue = 4 | pages = 745-50 | month =  | year =  | doi =  | PMID = 12066202 }}</ref>
*Alpha-smooth muscle actin +ve.
*CD35 +ve.
==See also==
==See also==
*[[Kidney tumours]].
*[[Kidney tumours]].
*[[Renal medullary carcinoma]].
*[[Renal medullary dysplasia]].


==References==
==References==

Latest revision as of 15:40, 14 October 2016

Renomedullary interstitial cell tumour
Diagnosis in short

Renal medullary fibroma. H&E stain.
Synonyms renal medullary fibroma
LM small polygonal/stellate cells in abundant loose/myxoid stroma, +/-entrapped renal tubules
LM DDx renal myxoma, edge of medium-sized blood vessel
IHC alpha-SMA +ve, CD35 +ve
Gross small (usu. <3 mm), white, well-circumscribed nodule - medulla of kidney
Site kidney - see kidney tumours
Prevalence common
Prognosis benign

Renomedullary interstitial cell tumour, also known as medullary fibroma,[1] is a relatively common benign tumour of the kidney.

General

  • Benign.
  • Common autopsy finding[2] - one review says 26-41% of individuals at autopsy.[3]
    • The commonality is somewhat in dispute.[4]

Gross

  • Small, white well-circumscribed nodule in medulla.
    • Typically less than 3 mm.[3]

Image:

Microscopic

Features:[2][5]

  • Small polygonal/stellate cells.
  • Abundant loose/myxoid stroma.
  • +/-Entrapped renal tubules.[6]

DDx:

  • Renal myxoma.[7]
  • Edge of medium-sized blood vessel.

Images

  • Renal medullary fibroma - low mag. (WC/Nephron)

  • Renal medullary fibroma - intermed. mag. (WC/Nephron)

  • Renal medullary fibroma - high mag. (WC/Nephron)

  • Renal medullary fibroma - very high mag. (WC/Nephron)

www:

IHC

Features:[6]

  • Alpha-smooth muscle actin +ve.
  • CD35 +ve.

See also

References

  1. ↑ Bircan, S.; Orhan, D.; Tulunay, O.; Safak, M. (2000). "Renomedullary interstitial cell tumor.". Urol Int 65 (3): 163-6. PMID 11054036.
  2. ↑ 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 295. ISBN 978-0781765275.
  3. ↑ 3.0 3.1 Tsurukawa, H.; Iuchi, H.; Osanai, H.; Yamaguchi, S.; Hashimoto, H.; Kaneko, S.; Yachiku, S. (Jan 2000). "[Renomedullary interstitial cell tumor: a case report].". Nihon Hinyokika Gakkai Zasshi 91 (1): 37-40. PMID 10689882.
  4. ↑ Kozłowska, J.; Okoń, K. (2008). "Renal tumors in postmortem material.". Pol J Pathol 59 (1): 21-5. PMID 18655367.
  5. ↑ URL: http://webpathology.com/image.asp?n=16&Case=71. Accessed on: 17 October 2011.
  6. ↑ 6.0 6.1 Kuroda, N.; Toi, M.; Miyazaki, E.; Hayashi, Y.; Nakayama, H.; Hiroi, M.; Enzan, H.. "Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors.". Oncol Rep 9 (4): 745-50. PMID 12066202.
  7. ↑ Melamed, J.; Reuter, VE.; Erlandson, RA.; Rosai, J. (Feb 1994). "Renal myxoma. A report of two cases and review of the literature.". Am J Surg Pathol 18 (2): 187-94. PMID 8291657.
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