Difference between revisions of "Chagas disease"
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*Depends on phase of infection. | *Depends on phase of infection. | ||
*[[cardiac arrhythmia|Arrhythmia]]s (late). | *[[cardiac arrhythmia|Arrhythmia]]s (late). | ||
*Toxic megacolon.<ref name=pmid1467905>{{Cite journal | last1 = Kobayasi | first1 = S. | last2 = Mendes | first2 = EF. | last3 = Rodrigues | first3 = MA. | last4 = Franco | first4 = MF. | title = Toxic dilatation of the colon in Chagas' disease. | journal = Br J Surg | volume = 79 | issue = 11 | pages = 1202-3 | month = Nov | year = 1992 | doi = | PMID = 1467905 }}</ref> | *[[Toxic megacolon]].<ref name=pmid1467905>{{Cite journal | last1 = Kobayasi | first1 = S. | last2 = Mendes | first2 = EF. | last3 = Rodrigues | first3 = MA. | last4 = Franco | first4 = MF. | title = Toxic dilatation of the colon in Chagas' disease. | journal = Br J Surg | volume = 79 | issue = 11 | pages = 1202-3 | month = Nov | year = 1992 | doi = | PMID = 1467905 }}</ref> | ||
*Chagas disease esophagopathy.<ref>{{Cite journal | last1 = Vicentine | first1 = FP. | last2 = Herbella | first2 = FA. | last3 = Allaix | first3 = ME. | last4 = Silva | first4 = LC. | last5 = Patti | first5 = MG. | title = Comparison of idiopathic achalasia and Chagas' disease esophagopathy at the light of high-resolution manometry. | journal = Dis Esophagus | volume = 27 | issue = 2 | pages = 128-33 | month = Feb | year = 2014 | doi = 10.1111/dote.12098 | PMID = 23795824 }}</ref> | |||
**[[Achalasia]]-like pathology with dilation of the esophagus. | |||
Dx:<ref>URL: [http://www.cdc.gov/parasites/chagas/diagnosis.html http://www.cdc.gov/parasites/chagas/diagnosis.html]. Accessed on: 4 December 2011.</ref> | Dx:<ref>URL: [http://www.cdc.gov/parasites/chagas/diagnosis.html http://www.cdc.gov/parasites/chagas/diagnosis.html]. Accessed on: 4 December 2011.</ref> | ||
Latest revision as of 00:45, 2 March 2014
Chagas disease, also known as American trypanosomiasis, is an infectious disease that affect various organs.
General
- Essentially a South American disease.
- Etiology: protozoa Trypanosoma cruzi - transmitted by reduvid bugs,[1] also known as kissing bug.[2]
Clinical:[3]
- Depends on phase of infection.
- Arrhythmias (late).
- Toxic megacolon.[4]
- Chagas disease esophagopathy.[5]
- Achalasia-like pathology with dilation of the esophagus.
Dx:[6]
- Usually serology.
- Thin blood smear.
Tx:
- Antimicrobials: benznidazole, nifurtimox.[1]
Microscopic
Features - heart:
- Inflammation - main finding.[3]
- Intramuscular organisms (without an inflammatory response).
- Neuronal loss in atrial ganglia.[7]
DDx:
- Toxoplasmosis.[8] (???)
Images:
IHC
- Anti–T cruzi immunoperoxidase.[7]
See also
References
- ↑ 1.0 1.1 URL: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002348/. Accessed on: 4 December 2011.
- ↑ URL: http://www.who.int/topics/chagas_disease/en/. Accessed on: 1 December 2011.
- ↑ 3.0 3.1 Teixeira, AR.; Nascimento, RJ.; Sturm, NR. (Aug 2006). "Evolution and pathology in chagas disease--a review.". Mem Inst Oswaldo Cruz 101 (5): 463-91. PMID 17072450.
- ↑ Kobayasi, S.; Mendes, EF.; Rodrigues, MA.; Franco, MF. (Nov 1992). "Toxic dilatation of the colon in Chagas' disease.". Br J Surg 79 (11): 1202-3. PMID 1467905.
- ↑ Vicentine, FP.; Herbella, FA.; Allaix, ME.; Silva, LC.; Patti, MG. (Feb 2014). "Comparison of idiopathic achalasia and Chagas' disease esophagopathy at the light of high-resolution manometry.". Dis Esophagus 27 (2): 128-33. doi:10.1111/dote.12098. PMID 23795824.
- ↑ URL: http://www.cdc.gov/parasites/chagas/diagnosis.html. Accessed on: 4 December 2011.
- ↑ 7.0 7.1 Marin-Neto, JA.; Cunha-Neto, E.; Maciel, BC.; Simões, MV. (Mar 2007). "Pathogenesis of chronic Chagas heart disease.". Circulation 115 (9): 1109-23. doi:10.1161/CIRCULATIONAHA.106.624296. PMID 17339569.
- ↑ URL: http://path.upmc.edu/cases/case160/micro.html. Accessed on: 8 January 2012.
- ↑ Higuchi, Mde L.; Benvenuti, LA.; Martins Reis, M.; Metzger, M. (Oct 2003). "Pathophysiology of the heart in Chagas' disease: current status and new developments.". Cardiovasc Res 60 (1): 96-107. PMID 14522411.