Difference between revisions of "Cytokeratin 20"
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'''Cytokeratin 20''', abbreviated '''CK20''' is a commonly used [[immunostain]]. It is also known as '''keratin 20'''. | [[Image:Small intestine - ck20 - intermed mag.jpg|thumb|200px|right|CK20 staining in [[small intestine]].]] | ||
'''Cytokeratin 20''', abbreviated '''CK20''', is a commonly used [[immunostain]]. It is also known as '''keratin 20'''. | |||
* | ==Positive== | ||
===CK20 positive and CK7 negative=== | |||
*Virtually all [[colorectal carcinoma]]s.<ref name=pmid11007036>{{Cite journal | last1 = Chu | first1 = P. | last2 = Wu | first2 = E. | last3 = Weiss | first3 = LM. | title = Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. | journal = Mod Pathol | volume = 13 | issue = 9 | pages = 962-72 | month = Sep | year = 2000 | doi = 10.1038/modpathol.3880175 | PMID = 11007036 }}</ref> | |||
*[[Merkel cell carcinoma]] - perinuclear dot-like pattern. | |||
*[[Eosinophilic, solid and cystic renal cell carcinoma]] - an evolving entity. | |||
===Partially CK20 positive=== | |||
*Corticotrophic [[pituitary adenoma]]s and [[Crooke-hyaline change]]s.<ref name=pmid17525485>{{Cite journal | last1 = Eschbacher | first1 = JM. | last2 = Coons | first2 = SW. | title = Cytokeratin CK20 is a sensitive marker for Crooke's cells and the early cytoskeletal changes associated with hypercortisolism within pituitary corticotrophs. | journal = Endocr Pathol | volume = 17 | issue = 4 | pages = 365-76 | month = | year = 2006 | doi = | PMID = 17525485 }}</ref> | |||
===CK20 positive and CK7 positive=== | |||
*Pancreatic adenocarcinoma. | |||
*Ovarian mucinous carcinoma. | |||
*Occasionally stomach adenocarcinoma, cholangiocarcinoma. | |||
*[[Urothelial carcinoma]]. | |||
*[[Esophageal adenocarcinoma]]. | |||
====Images==== | |||
<gallery> | |||
Image: Urothelial carcinoma - CK20 -- intermed mag.jpg | UCC - CK20 - intermed. mag. (WC) | |||
Image: Urothelial carcinoma - CK20 -- high mag.jpg | UCC - CK20 - high mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
*[[Immunohistochemistry]]. | *[[Immunohistochemistry]]. | ||
*[[CK7]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|1 | ||
}} | |||
[[Category:Immunohistochemistry]] | [[Category:Immunohistochemistry]] | ||
Latest revision as of 13:41, 5 January 2017
CK20 staining in small intestine.
Cytokeratin 20, abbreviated CK20, is a commonly used immunostain. It is also known as keratin 20.
Positive
CK20 positive and CK7 negative
- Virtually all colorectal carcinomas.[1]
- Merkel cell carcinoma - perinuclear dot-like pattern.
- Eosinophilic, solid and cystic renal cell carcinoma - an evolving entity.
Partially CK20 positive
- Corticotrophic pituitary adenomas and Crooke-hyaline changes.[2]
CK20 positive and CK7 positive
- Pancreatic adenocarcinoma.
- Ovarian mucinous carcinoma.
- Occasionally stomach adenocarcinoma, cholangiocarcinoma.
- Urothelial carcinoma.
- Esophageal adenocarcinoma.
Images
UCC - CK20 - intermed. mag. (WC)
UCC - CK20 - high mag. (WC)
See also
References
- ↑ Chu, P.; Wu, E.; Weiss, LM. (Sep 2000). "Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases.". Mod Pathol 13 (9): 962-72. doi:10.1038/modpathol.3880175. PMID 11007036.
- ↑ Eschbacher, JM.; Coons, SW. (2006). "Cytokeratin CK20 is a sensitive marker for Crooke's cells and the early cytoskeletal changes associated with hypercortisolism within pituitary corticotrophs.". Endocr Pathol 17 (4): 365-76. PMID 17525485.