Difference between revisions of "Thyroid transcription factor-1"
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| Image = Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg | |||
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| Caption = TTF-1 staining in [[lung adenocarcinoma]]. (WC) | |||
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| Pattern = nuclear staining | |||
| Positive = [[adenocarcinoma of the lung]], [[small cell carcinoma of the lung]], thyroid, [[hepatocellular carcinoma]] (cytoplasmic staining) | |||
| Negative = [[squamous cell carcinoma of the lung]] | |||
| Other = | |||
}} | |||
'''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. | journal = Adv Anat Pathol | volume = 7 | issue = 2 | pages = 123-7 | month = Mar | year = 2000 | doi = | PMID = 10721419 }}</ref> | '''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. | journal = Adv Anat Pathol | volume = 7 | issue = 2 | pages = 123-7 | month = Mar | year = 2000 | doi = | PMID = 10721419 }}</ref> | ||
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==Tumours== | ==Tumours== | ||
*[[Lung adenocarcinoma]].<ref>{{Cite journal | last1 = Yatabe | first1 = Y. | last2 = Mitsudomi | first2 = T. | last3 = Takahashi | first3 = T. | title = TTF-1 expression in pulmonary adenocarcinomas. | journal = Am J Surg Pathol | volume = 26 | issue = 6 | pages = 767-73 | month = Jun | year = 2002 | doi = | PMID = 12023581 }}</ref> | ===Positive staining=== | ||
*[[Small cell carcinoma of the lung]]. | *[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal | last1 = Yatabe | first1 = Y. | last2 = Mitsudomi | first2 = T. | last3 = Takahashi | first3 = T. | title = TTF-1 expression in pulmonary adenocarcinomas. | journal = Am J Surg Pathol | volume = 26 | issue = 6 | pages = 767-73 | month = Jun | year = 2002 | doi = | PMID = 12023581 }}</ref> | ||
**[[Small cell carcinoma of the lung]] ~ 91% positive (157 +ve of 173<ref name=pmid37139017>{{cite journal |authors=Sayeda S, Naqvi A, Begum H, Juergens RA, Finley C, Coschi CH, Cutz JC, Bonert M |title=Prevalence of Thyroid Transcription Factor-1 (TTF-1)-Negative Small Cell Carcinoma and Napsin A Positivity in Small Cell Carcinoma in a Cross-Sectional Study of Lung Core Biopsies |journal=Cureus |volume=15 |issue=4 |pages=e37015 |date=April 2023 |pmid=37139017 |pmc=10151064 |doi=10.7759/cureus.37015 |url=}}</ref>). | |||
**[[Adenocarcinoma of the lung]]. | |||
*Thyroid carcinoma. | |||
*[[Hepatocellular carcinoma]] (cytoplasmic staining, nuclei negative).<ref name=pmid22359993>{{Cite journal | last1 = Mishra | first1 = M. | last2 = Morgan | first2 = V. | last3 = Hamati | first3 = AK. | last4 = Al-Abbadi | first4 = M. | title = Carcinoma of unknown primary: check the liver... thanks to TTF-1. | journal = Tenn Med | volume = 105 | issue = 1 | pages = 35-6, 40 | month = Jan | year = 2012 | doi = | PMID = 22359993 }}</ref> | |||
* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal | last1 = Mete | first1 = O. | last2 = Lopes | first2 = MB. | last3 = Asa | first3 = SL. | title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1694-9 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829723e7 | PMID = 23887161 }}</ref> | |||
*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal | last1 = Hewer | first1 = E. | last2 = Vajtai | first2 = I. | title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. | journal = Clin Neuropathol | volume = 34 | issue = 3 | pages = 128-31 | month = | year = | doi = 10.5414/NP300818 | PMID = 25669749 }}</ref> | |||
===Negative=== | ===Negative staining=== | ||
*[[Squamous cell carcinoma of the lung]]. | *[[Squamous cell carcinoma of the lung]]. | ||
*[[SMARCA4-deficient non-small cell carcinoma of the lung]] - typically ~ 5% of [[lung adenocarcinoma]] is TTF-1 negative. | |||
**These cases are often [[CK7]] positive, [[HepPar-1]] positive.<ref name=pmid28038711>{{Cite journal | last1 = Herpel | first1 = E. | last2 = Rieker | first2 = RJ. | last3 = Dienemann | first3 = H. | last4 = Muley | first4 = T. | last5 = Meister | first5 = M. | last6 = Hartmann | first6 = A. | last7 = Warth | first7 = A. | last8 = Agaimy | first8 = A. | title = SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens. | journal = Ann Diagn Pathol | volume = 26 | issue = | pages = 47-51 | month = Feb | year = 2017 | doi = 10.1016/j.anndiagpath.2016.10.006 | PMID = 28038711 }}</ref> | |||
===Images=== | |||
<gallery> | |||
File:Adenocarcinoma-Acinar type TTF1 (5494540752).jpg | TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen). | |||
File:Pituicytoma TTF1.jpg | TTF1 in a [[Pituicytoma]] (WC/jensflorian). | |||
</gallery> | |||
==See also== | ==See also== | ||
Latest revision as of 20:50, 27 November 2023
| Thyroid transcription factor-1 | |
|---|---|
| Immunostain in short | |
 TTF-1 staining in lung adenocarcinoma. (WC) | |
| Normal staining pattern | nuclear staining |
| Positive | adenocarcinoma of the lung, small cell carcinoma of the lung, thyroid, hepatocellular carcinoma (cytoplasmic staining) |
| Negative | squamous cell carcinoma of the lung |
Thyroid transcription factor-1, abbreviated TTF-1 is a transcription factor seen in lung and thyroid.[1]
Positive staining
- Nuclear staining.
Normal tissues
Tumours
Positive staining
- Lung adenocarcinoma.[2]
- Small cell carcinoma of the lung ~ 91% positive (157 +ve of 173[3]).
- Adenocarcinoma of the lung.
- Thyroid carcinoma.
- Hepatocellular carcinoma (cytoplasmic staining, nuclei negative).[4]
- Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. [5]
- Subependymal giant cell astrocytoma [6]
Negative staining
- Squamous cell carcinoma of the lung.
- SMARCA4-deficient non-small cell carcinoma of the lung - typically ~ 5% of lung adenocarcinoma is TTF-1 negative.
Images
TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen).
TTF1 in a Pituicytoma (WC/jensflorian).
.jpg)
See also
References
- ↑ Ordóñez, NG. (Mar 2000). "Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas.". Adv Anat Pathol 7 (2): 123-7. PMID 10721419.
- ↑ Yatabe, Y.; Mitsudomi, T.; Takahashi, T. (Jun 2002). "TTF-1 expression in pulmonary adenocarcinomas.". Am J Surg Pathol 26 (6): 767-73. PMID 12023581.
- ↑ Sayeda S, Naqvi A, Begum H, Juergens RA, Finley C, Coschi CH, Cutz JC, Bonert M (April 2023). "Prevalence of Thyroid Transcription Factor-1 (TTF-1)-Negative Small Cell Carcinoma and Napsin A Positivity in Small Cell Carcinoma in a Cross-Sectional Study of Lung Core Biopsies". Cureus 15 (4): e37015. doi:10.7759/cureus.37015. PMC 10151064. PMID 37139017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151064/.
- ↑ Mishra, M.; Morgan, V.; Hamati, AK.; Al-Abbadi, M. (Jan 2012). "Carcinoma of unknown primary: check the liver... thanks to TTF-1.". Tenn Med 105 (1): 35-6, 40. PMID 22359993.
- ↑ Mete, O.; Lopes, MB.; Asa, SL. (Nov 2013). "Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.". Am J Surg Pathol 37 (11): 1694-9. doi:10.1097/PAS.0b013e31829723e7. PMID 23887161.
- ↑ Hewer, E.; Vajtai, I.. "Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis.". Clin Neuropathol 34 (3): 128-31. doi:10.5414/NP300818. PMID 25669749.
- ↑ Herpel, E.; Rieker, RJ.; Dienemann, H.; Muley, T.; Meister, M.; Hartmann, A.; Warth, A.; Agaimy, A. (Feb 2017). "SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.". Ann Diagn Pathol 26: 47-51. doi:10.1016/j.anndiagpath.2016.10.006. PMID 28038711.