Difference between revisions of "Ganglioneuroma"
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| Image = Adrenal Ganglioneuroma MP2 14BR***.jpg | | Image = Adrenal Ganglioneuroma MP2 14BR***.jpg | ||
| Width = | | Width = | ||
| Caption = Adrenal Ganglioneuroma [[H&E stain]]. | | Caption = Adrenal Ganglioneuroma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = ganglion cells (large cells with large nucleus and prominent nucleolus), disordered fibrinous-like material, eosinophilic granular bodies | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[ganglioneuroblastoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = synaptophysin +ve, S-100 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 15: | Line 15: | ||
| Gross = solid, firm, white | | Gross = solid, firm, white | ||
| Grossing = | | Grossing = | ||
| Site = usually adrenal or retroperitoneal | | Site = usually adrenal or retroperitoneal, paraspinal | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 21: | Line 21: | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
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*[http://www.webpathology.com/image.asp?case=84&n=1 Ganglioneuroma (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=84&n=1 Ganglioneuroma (webpathology.com)]. | ||
==Microscopic== | |||
Features: | Features: | ||
*Ganglion cells - '''key feature'''. | *Ganglion cells - '''key feature'''. | ||
| Line 102: | Line 102: | ||
*Spindle cells: S-100 +ve. | *Spindle cells: S-100 +ve. | ||
*Ganglion cells: NSE, synaptophysin, NF. | *Ganglion cells: NSE, synaptophysin, NF. | ||
==Sign out== | |||
<pre> | |||
Paraspinal Lesion, Right, Core Biopsy: | |||
- Ganglioneuroma. | |||
Comment: | |||
The lesion stains as follows: | |||
POSITIVE: S-100 & vimentin (stroma, ganglion cells), synaptophysin (ganglion cells only). | |||
NEGATIVE: AE1/AE3, CD34. | |||
PROLIFERATION (Ki-67): <1% of cells. | |||
</pre> | |||
==See also== | ==See also== | ||
Latest revision as of 00:29, 5 May 2016
| Ganglioneuroma | |
|---|---|
| Diagnosis in short | |
 Adrenal Ganglioneuroma. H&E stain. | |
|
| |
| LM | ganglion cells (large cells with large nucleus and prominent nucleolus), disordered fibrinous-like material, eosinophilic granular bodies |
| LM DDx | ganglioneuroblastoma |
| IHC | synaptophysin +ve, S-100 +ve |
| Gross | solid, firm, white |
| Site | usually adrenal or retroperitoneal, paraspinal |
|
| |
| Prevalence | uncommon |
| Prognosis | good |
Ganglioneuroma is a benign neuroblasic tumour. It is also known as ganglioma.[1]
It should not to be confused with ganglioglioma.
General
- May be retroperitoneal.
- Occasionally found in the GI tract - may form colonic polyp.
- Multiple ganglioneuromas may be due to multiple endocrine neoplasia IIb.
Classification:
- In a grouping known as neuroblastic tumours which includes:[2]
- Ganglioneuroma (benign).
- Ganglioneuroblastoma (intermediate).
- Neuroblastoma (aggressive).
Gross
- Solid.
- White.
- Firm.
- Well-circumscribed.
- May be nodular.
Images
Adrenal ganglioneuroma. (WC)
www:
Microscopic
Features:
- Ganglion cells - key feature.
- Large cells with large nucleus.
- Prominent nucleolus.
- Large cells with large nucleus.
- Disordered fibrinous-like material.
- Eosinophilic granular bodies.[3]
See: adrenal ganglioneuroma, colonic ganglioneuroma.
Images
Ganglioneuroma. (WC)
A normal ganglion. (WC)
Adrenal Ganglioneuroma - Medium power (SKB)
Adrenal Ganglioneuroma - Medium power (SKB)
Adrenal Ganglioneuroma - Low power (SKB)
Adrenal Ganglioneuroma - Medium power (SKB)
Adrenal Ganglioneuroma - Medium power (SKB)
Adrenal Ganglioneuroma - Medium power (SKB)
Adrenal Ganglioneuroma - High power (SKB)
Adrenal Ganglioneuroma - synaptophysin (SKB)
Adrenal Ganglioneuroma - Low power (SKB)
Adrenal Ganglioneuroma - Medium power (SKB)
Adrenal Ganglioneuroma - Medium power (SKB)
Adrenal Ganglioneuroma - Medium power (SKB)
Adrenal Ganglioneuroma - Medium power (SKB)
Abdominal Ganglioneuroma, HE stain. (WC/jensflorian)
Retroperitoneal Ganglioneuroma. (Ed Uthman)
Histopathological image of ganglioneuroma in the posterior wall of pharynx. (WC/KGH)
Ganglioneuroma in colonic biopsy (WC/Nephron)
Ganglioneuroma in colonic biopsy, high mag (WC/Nephron)
.jpg)
.jpg)
www:
IHC
Features:[4]
- Spindle cells: S-100 +ve.
- Ganglion cells: NSE, synaptophysin, NF.
Sign out
Paraspinal Lesion, Right, Core Biopsy: - Ganglioneuroma. Comment: The lesion stains as follows: POSITIVE: S-100 & vimentin (stroma, ganglion cells), synaptophysin (ganglion cells only). NEGATIVE: AE1/AE3, CD34. PROLIFERATION (Ki-67): <1% of cells.
See also
References
- ↑ URL: http://medical-dictionary.thefreedictionary.com/ganglioma. Accessed on: 8 November 2010.
- ↑ Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B (July 1999). "Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee". Cancer 86 (2): 349–63. PMID 10421272.
- ↑ R. Kiehl. 8 November 2010.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 217. ISBN 978-0443066573.