Difference between revisions of "Cytokeratin 7"
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[[Image: | [[Image:Urothelial carcinoma - CK7 -- high mag.jpg|thumb|right|CK7 immunostain in [[urothelial carcinoma]]. (WC)]] | ||
'''Cytokeratin 7''', also '''keratin 7''' and '''CK7''', is a common low molecular keratin and a very common [[immunostain]].<ref name=pmid11007036>{{Cite journal | last1 = Chu | first1 = P. | last2 = Wu | first2 = E. | last3 = Weiss | first3 = LM. | title = Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. | journal = Mod Pathol | volume = 13 | issue = 9 | pages = 962-72 | month = Sep | year = 2000 | doi = 10.1038/modpathol.3880175 | PMID = 11007036 }}</ref> | '''Cytokeratin 7''', also '''keratin 7''' and '''CK7''', is a common low molecular keratin and a very common [[immunostain]].<ref name=pmid11007036>{{Cite journal | last1 = Chu | first1 = P. | last2 = Wu | first2 = E. | last3 = Weiss | first3 = LM. | title = Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. | journal = Mod Pathol | volume = 13 | issue = 9 | pages = 962-72 | month = Sep | year = 2000 | doi = 10.1038/modpathol.3880175 | PMID = 11007036 }}</ref> | ||
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*Esophageal adenocarcinoma. | *Esophageal adenocarcinoma. | ||
====Images==== | |||
<gallery> | |||
Image:Adenocarcinoma - CK7 immunostain (5762463282).jpg | Adenocarcinoma of the lung. (WC/Yale Rosen) | |||
Image:Adenocarcinoma-Acinar type CK7 (5494540614).jpg| CK7 immunostain in acinar [[adenocarcinoma of the lung]]. (WC) | |||
</gallery> | |||
==Negative== | ==Negative== | ||
===Classic negative=== | ===Classic negative=== | ||
*Kidney<ref name=pmid11007036/> ([[clear cell renal cell carcinoma]]). | *Kidney<ref name=pmid11007036/> ([[clear cell renal cell carcinoma]]). † | ||
*Colon and rectum.<ref name=pmid11007036/> | *Colon and rectum.<ref name=pmid11007036/> | ||
*Prostate.<ref name=pmid11007036/> | *Prostate.<ref name=pmid11007036/> | ||
*Thymus.<ref name=pmid11007036/> | *Thymus.<ref name=pmid11007036/> | ||
*[[Squamous cell carcinoma]]. | *[[Squamous cell carcinoma]]. ‡ | ||
Notes: | Notes: | ||
* | * † Most other common types are CK7 +ve ([[papillary RCC]], [[chromophobe RCC]], [[clear cell papillary RCC]]) | ||
* ‡ May be positive. In one series of head and neck SCC, conventional SCC: 7 +ve of 34 cases; [[basaloid squamous cell carcinoma]]: 24 +ve of 45 cases.<ref name=pmid20614292>{{Cite journal | last1 = Winters | first1 = R. | last2 = Naud | first2 = S. | last3 = Evans | first3 = MF. | last4 = Trotman | first4 = W. | last5 = Kasznica | first5 = P. | last6 = Elhosseiny | first6 = A. | title = Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases. | journal = Head Neck Pathol | volume = 2 | issue = 4 | pages = 265-71 | month = Dec | year = 2008 | doi = 10.1007/s12105-008-0089-7 | PMID = 20614292 }}</ref> | |||
====Images==== | |||
<gallery> | <gallery> | ||
File: | File:Lymphoma - lung - CK7 -- intermed mag.jpg|Entrapped CK7-positive lung parenchyma within a lymphoma. (WC) | ||
</gallery> | </gallery> | ||
Latest revision as of 04:19, 5 January 2017
CK7 immunostain in urothelial carcinoma. (WC)
Cytokeratin 7, also keratin 7 and CK7, is a common low molecular keratin and a very common immunostain.[1]
Positive
Classic positive
- Ovary.
- Breast.
- Endometrium.
- Salivary gland.
- Lung (adenocarcinoma).
- Thyroid gland.
- Mesothelium.
- Pancreas.
- Stomach.
- Urothelial carcinoma.
- Esophageal adenocarcinoma.
Images
Adenocarcinoma of the lung. (WC/Yale Rosen)
CK7 immunostain in acinar adenocarcinoma of the lung. (WC)
.jpg)
.jpg)
Negative
Classic negative
- Kidney[1] (clear cell renal cell carcinoma). †
- Colon and rectum.[1]
- Prostate.[1]
- Thymus.[1]
- Squamous cell carcinoma. ‡
Notes:
- † Most other common types are CK7 +ve (papillary RCC, chromophobe RCC, clear cell papillary RCC)
- ‡ May be positive. In one series of head and neck SCC, conventional SCC: 7 +ve of 34 cases; basaloid squamous cell carcinoma: 24 +ve of 45 cases.[2]
Images
Entrapped CK7-positive lung parenchyma within a lymphoma. (WC)
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Chu, P.; Wu, E.; Weiss, LM. (Sep 2000). "Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases.". Mod Pathol 13 (9): 962-72. doi:10.1038/modpathol.3880175. PMID 11007036.
- ↑ Winters, R.; Naud, S.; Evans, MF.; Trotman, W.; Kasznica, P.; Elhosseiny, A. (Dec 2008). "Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases.". Head Neck Pathol 2 (4): 265-71. doi:10.1007/s12105-008-0089-7. PMID 20614292.