Difference between revisions of "Serous borderline tumour"

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| Caption    = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].
| Caption    = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].
| Synonyms  =
| Synonyms  =
| Micro      =
| Micro      = cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)
| Subtypes  =
| Subtypes  = serous borderline tumour (SBT) with micropapillary pattern, typical SBT ''or'' SBT not otherwise specified
| LMDDx      = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]  
| LMDDx      = [[serous cystadenoma of the ovary|serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]  
| Stains    =
| Stains    =
| IHC        =
| IHC        =
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Features:<ref name=Ref_GP399>{{Ref GP|399}}</ref>
Features:<ref name=Ref_GP399>{{Ref GP|399}}</ref>
*Cuboidal to columnar epithelium with mild to moderate atypia.
*Cuboidal to columnar epithelium with mild to moderate atypia.
*No invasive.
*Non-invasive.
*"Sparse" mitoses.
*"Sparse" mitoses.
*+/-[[Psammoma bodies]].
*+/-[[Psammoma bodies]].
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**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).  
**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).  
*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.
*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.
*[[Serous cystadenoma]].
*[[Serous cystadenoma of the ovary]].


===Images===
===Images===
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<pre>
<pre>
Cyst and Right Fallopian Tube, Excision:
Cyst and Right Fallopian Tube, Excision:
    - SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
    - Fallopian tube within normal limits.
- Fallopian tube within normal limits.
    - NEGATIVE for evidence of invasion.
- NEGATIVE for evidence of invasion.


Comment:
Comment:

Latest revision as of 11:25, 29 March 2016

Serous borderline tumour
Diagnosis in short

Serous borderline tumour with a micropapillary pattern. H&E stain.
LM cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-psammoma bodies, +/-micropapillary architecture (often described as a medusa head pattern)
Subtypes serous borderline tumour (SBT) with micropapillary pattern, typical SBT or SBT not otherwise specified
LM DDx serous cystadenoma, serous carcinoma of the ovary, clear cell carcinoma of the ovary
Site ovary, uterine tube - see ovarian tumours
Prevalence uncommon
Prognosis usually benign, need follow-up
Clin. DDx other ovarian tumours (benign and malignant)
Treatment excision, follow-up

Serous borderline tumour is a Muellerian epithelial ovarian tumour with a behaviour that borders on malignant.

It is also known as serous tumour of low malignant potential, abbreviated SLMP.[1][2]

Serous ovarian tumour of low malignant potential redirects here.[2]

General

  • Usually benign.
  • Require long term follow-up.

Microscopic

Features:[3]

  • Cuboidal to columnar epithelium with mild to moderate atypia.
  • Non-invasive.
  • "Sparse" mitoses.
  • +/-Psammoma bodies.
  • +/-Micropapillary architecture - often described as a medusa head pattern.

DDx:

Images

  • SBTMP - very very low mag.

  • SBTMP - very low mag.

  • SBTMP - low mag.

  • SBTMP - intermed. mag.

  • SBTMP - high mag.

  • SBTMP - very low mag.

  • SBTMP - low mag.

  • SBTMP - intermed. mag.

  • SBTMP - high mag.

  • SBTMP - high mag.

  • SBTMP - high mag.

  • SBTMP - very high mag.

www

Subclassification

Typical subdivided into:[5]

  • Micropapillary serous borderline tumour.
  • Typical serous borderline tumour (SBOT).

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Cyst and Right Fallopian Tube, Excision:
- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
- Fallopian tube within normal limits.
- NEGATIVE for evidence of invasion.

Comment:
The lesion appears to be confined to a cystic structure.

See also

References

  1. ↑ Seidman, JD.; Kurman, RJ. (May 2000). "Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.". Hum Pathol 31 (5): 539-57. PMID 10836293.
  2. ↑ 2.0 2.1 Dietel, M.; Hauptmann, S. (May 2000). "Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology.". Virchows Arch 436 (5): 403-12. PMID 10881733.
  3. ↑ 3.0 3.1 3.2 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 399. ISBN 978-0443069208.
  4. ↑ Burkholz, KJ.; Wood, BP.; Zuppan, C.. "Best cases from the AFIP: Borderline papillary serous tumor of the right ovary.". Radiographics 25 (6): 1689-92. doi:10.1148/rg.256055015. PMID 16284143.
  5. ↑ Park, JY.; Kim, DY.; Kim, JH.; Kim, YM.; Kim, KR.; Kim, YT.; Nam, JH. (Dec 2011). "Micropapillary pattern in serous borderline ovarian tumors: does it matter?". Gynecol Oncol 123 (3): 511-6. doi:10.1016/j.ygyno.2011.08.008. PMID 21917305.
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