Difference between revisions of "Pleural plaque"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Pleural plaque - 2 -- very low mag.jpg | |||
| Width = | |||
| Caption = [[Micrograph]] of a pleural plaque. [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = | |||
| Micro = hyaline (fibrosis) material +/-[[calcification]]s | |||
| Subtypes = | |||
| LMDDx = [[fibrosing pleuritis]], [[malignant mesothelioma]] - especially [[desmoplastic mesothelioma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = white pleural lesions | |||
| Grossing = | |||
| Staging = | |||
| Site = [[pleura]] | |||
| Assdx = [[asbestosis]], [[malignant mesothelioma]] | |||
| Syndromes = | |||
| Clinicalhx = exposure to asbestos | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = pleural thickening | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = [[malignant mesothelioma]], metastatic [[carcinoma]] | |||
| Tx = | |||
}} | |||
A '''pleural plaque''' is a benign fibrous thickening of the [[pleura]]. It is strongly associated with asbestos exposure.<ref name=pmid22617814>{{Cite journal | last1 = Myers | first1 = R. | title = Asbestos-related pleural disease. | journal = Curr Opin Pulm Med | volume = 18 | issue = 4 | pages = 377-81 | month = Jul | year = 2012 | doi = 10.1097/MCP.0b013e328354acfe | PMID = 22617814 }}</ref> | A '''pleural plaque''' is a benign fibrous thickening of the [[pleura]]. It is strongly associated with asbestos exposure.<ref name=pmid22617814>{{Cite journal | last1 = Myers | first1 = R. | title = Asbestos-related pleural disease. | journal = Curr Opin Pulm Med | volume = 18 | issue = 4 | pages = 377-81 | month = Jul | year = 2012 | doi = 10.1097/MCP.0b013e328354acfe | PMID = 22617814 }}</ref> | ||
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Other asbestos-related pleural disease:<ref name=pmid22617814/> | Other asbestos-related pleural disease:<ref name=pmid22617814/> | ||
*Diffuse pleural thickening. | *Diffuse pleural thickening. | ||
*Benign asbestos-related pleural | *Benign asbestos-related [[pleural effusion]]s (BAPEs). | ||
*[[Malignant mesothelioma]]. | *[[Malignant mesothelioma]]. | ||
==Gross== | ==Gross== | ||
| Line 35: | Line 67: | ||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Pleural plaque -- extremely low mag.jpg | PP - extremely low mag. (WC) | |||
Image: Pleural plaque -- very low mag.jpg | PP - very low mag. (WC) | |||
Image: Pleural plaque -- low mag.jpg | PP - low mag. (WC) | |||
Image: Pleural plaque -- intermed mag.jpg | PP - intermed. mag. (WC) | |||
Image: Pleural plaque -- high mag.jpg | PP - high mag. (WC) | |||
Image: Pleural plaque - 2 -- very low mag.jpg | PP - low mag. (WC) | |||
Image: Pleural plaque - 2a -- very low mag.jpg | PP - low mag. (WC) | |||
Image: Pleural plaque - 2 -- low mag.jpg | PP - low mag. (WC) | |||
Image: Pleural plaque - 2 -- intermed mag.jpg | PP - intermed. mag. (WC) | |||
Image: Pleural plaque - 2a -- intermed mag.jpg | PP - intermed. mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://library.med.utah.edu/WebPath/LUNGHTML/LUNG102.html Pleural plaque (utah.edu)]. | *[http://library.med.utah.edu/WebPath/LUNGHTML/LUNG102.html Pleural plaque (utah.edu)]. | ||
==Sign out== | |||
<pre> | |||
Pleura, Left Lung, Biopsy: | |||
- Fibrous pleuritis/pleural plaque (fibrous tissue with mild chronic inflammation | |||
and calcifications). | |||
- NEGATIVE for evidence of malignancy. | |||
</pre> | |||
==See also== | ==See also== | ||
Latest revision as of 12:37, 14 June 2016
| Pleural plaque | |
|---|---|
| Diagnosis in short | |
 Micrograph of a pleural plaque. H&E stain. (WC/Nephron) | |
|
| |
| LM | hyaline (fibrosis) material +/-calcifications |
| LM DDx | fibrosing pleuritis, malignant mesothelioma - especially desmoplastic mesothelioma |
| Gross | white pleural lesions |
| Site | pleura |
|
| |
| Associated Dx | asbestosis, malignant mesothelioma |
| Clinical history | exposure to asbestos |
| Prevalence | uncommon |
| Radiology | pleural thickening |
| Prognosis | benign |
| Clin. DDx | malignant mesothelioma, metastatic carcinoma |
A pleural plaque is a benign fibrous thickening of the pleura. It is strongly associated with asbestos exposure.[1]
General
- May be due to other causes.[2]
Other asbestos-related pleural disease:[1]
- Diffuse pleural thickening.
- Benign asbestos-related pleural effusions (BAPEs).
- Malignant mesothelioma.
Gross
- Thickened (or calcified) plaques.[2]
- White.
DDx:
- Metastatic carcinoma.
Images
Fibrous pleural plaque. (WC/Rosen)
.jpg)
Microscopic
Features:[3]
- Hyaline material +/- calcification.
Notes:
- Usually associated with asbestosis fibres in the lung (85% of cases).[3]
- Plaque burden seems to be associated with the number asbestos bodies found; many plaques... suggest many asbestosis bodies.
DDx:
Images
PP - extremely low mag. (WC)
PP - very low mag. (WC)
PP - low mag. (WC)
PP - intermed. mag. (WC)
PP - high mag. (WC)
PP - low mag. (WC)
PP - low mag. (WC)
PP - low mag. (WC)
PP - intermed. mag. (WC)
PP - intermed. mag. (WC)
www
Sign out
Pleura, Left Lung, Biopsy: - Fibrous pleuritis/pleural plaque (fibrous tissue with mild chronic inflammation and calcifications). - NEGATIVE for evidence of malignancy.
See also
- Asbestosis - lung has fibrosis.
- Malignant mesothelioma.
- Ferruginous bodies.
References
- ↑ 1.0 1.1 Myers, R. (Jul 2012). "Asbestos-related pleural disease.". Curr Opin Pulm Med 18 (4): 377-81. doi:10.1097/MCP.0b013e328354acfe. PMID 22617814.
- ↑ 2.0 2.1 Clarke, CC.; Mowat, FS.; Kelsh, MA.; Roberts, MA.. "Pleural plaques: a review of diagnostic issues and possible nonasbestos factors.". Arch Environ Occup Health 61 (4): 183-92. doi:10.3200/AEOH.61.4.183-192. PMID 17867573.
- ↑ 3.0 3.1 Roberts, GH. (May 1971). "The pathology of parietal pleural plaques.". J Clin Pathol 24 (4): 348-53. PMID 5556121.