Difference between revisions of "Squamous cell carcinoma of the lung"

From Libre Pathology
Jump to navigation Jump to search
(fix redirect)
(split out)
Line 1: Line 1:
#redirect [[Lung_tumours#Squamous_cell_carcinoma_of_the_lung]]
'''Squamous cell carcinoma of the lung''', also '''lung squamous cell carcinoma''', is a common [[cancer|malignant]] [[lung tumour]] that is associated with [[smoking]].
 
==General==
*Strong association with [[smoking]].
*May be treated with surgery.
 
==Gross==
*Usually centrally located, i.e. large airways.
 
==Microscopic==
Features:
*Central nucleus.
*Dense appearing cytoplasm, usu. eosinophilic.
*+/-Small nucleolus.
 
DDx:
*Metastatic [[squamous cell carcinoma]].
*[[Adenocarcinoma of the lung]].
*[[Non-small cell lung carcinoma]] - diagnosis should be avoid if possible.
 
==IHC==
*p40 +ve.<ref name=pmid22056955>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref>
**p63 +ve -- less specific.
*TTF-1 -ve.
**Positive in adenocarcinoma.
*Calponin -ve.
*CK5/6 +ve.
 
==See also==
*[[Squamous cell carcinoma]].
*[[Lung tumours]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Lung tumours]]

Revision as of 03:28, 12 January 2014

Squamous cell carcinoma of the lung, also lung squamous cell carcinoma, is a common malignant lung tumour that is associated with smoking.

General

  • Strong association with smoking.
  • May be treated with surgery.

Gross

  • Usually centrally located, i.e. large airways.

Microscopic

Features:

  • Central nucleus.
  • Dense appearing cytoplasm, usu. eosinophilic.
  • +/-Small nucleolus.

DDx:

IHC

  • p40 +ve.[1]
    • p63 +ve -- less specific.
  • TTF-1 -ve.
    • Positive in adenocarcinoma.
  • Calponin -ve.
  • CK5/6 +ve.

See also

References

  1. ↑ Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.
Retrieved from "https://librepathology.org/w/index.php?title=Squamous_cell_carcinoma_of_the_lung&oldid=27778"