Difference between revisions of "Adamantinoma"
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*[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref> | *[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F1/ Adamantinoma (nih.gov)].<ref name=pmid18279517>{{Cite journal | last1 = Jain | first1 = D. | last2 = Jain | first2 = VK. | last3 = Vasishta | first3 = RK. | last4 = Ranjan | first4 = P. | last5 = Kumar | first5 = Y. | title = Adamantinoma: a clinicopathological review and update. | journal = Diagn Pathol | volume = 3 | issue = | pages = 8 | month = | year = 2008 | doi = 10.1186/1746-1596-3-8 | PMID = 18279517 }}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F2/ Adamantinoma (nih.gov)]. | |||
==IHC== | ==IHC== | ||
Revision as of 22:09, 29 August 2013
| Adamantinoma | |
|---|---|
| Diagnosis in short | |
 Adamantinoma. H&E stain. | |
| Site | bone - usu. tibia or fibula. |
|
| |
| Prevalence | uncommon |
| Prognosis | benign +/-locally aggressive |
| Clin. DDx | osteosarcoma |
Adamantinoma is an uncommon benign bone tumour. It should not be confused with adenomatoid tumour.
General
Features:[1]
- Rare: < 1% of bone tumours.
- 25-35 years old.
- Benign, may be locally aggressive.
- Cousin of ameloblastoma. (???)
Gross
- Tibia or fibula.
Radiology
- Intracortical, radiolucent.
Microscopic
Features:
- Biphasic tumour:
- Fibrous/spindle cell component.
- Epithelial component.
DDx:[2]
- Vascular tumours (Epithelioid hemangioendothelioma).
- Metastatic carcinoma.
Images
Adamantinoma - intermed. mag. (WC)
www:
IHC
Features:[2]
- CK14 +ve (HMWK).[5]
- CK19 +ve (LMWK).
- CK8/18 -ve (LMWK).
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 650. ISBN 978-0781765275.
- ↑ 2.0 2.1 URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2. Accessed on: 28 April 2011.
- ↑ URL: http://southbaypath.org/CaseImages/sb5260/sb5260.htm. Accessed on: 7 December 2010.
- ↑ Jain, D.; Jain, VK.; Vasishta, RK.; Ranjan, P.; Kumar, Y. (2008). "Adamantinoma: a clinicopathological review and update.". Diagn Pathol 3: 8. doi:10.1186/1746-1596-3-8. PMID 18279517.
- ↑ URL: http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm. Accessed on: 28 April 2011.