Difference between revisions of "Nucleus-to-cytoplasm ratio"
Jump to navigation
Jump to search
| Line 1: | Line 1: | ||
'''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated '''NC ratio'''. | '''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated '''NC ratio'''. | ||
High NC ratio is strong predictor of malignancy.<ref name=pmid16556320>{{Cite journal | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue = | pages = 11 | month = | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }} | High NC ratio is strong predictor of [[malignancy]].<ref name=pmid16556320>{{Cite journal | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue = | pages = 11 | month = | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }} | ||
</ref> Like very rule, there are exceptions. | </ref> Like very rule, there are exceptions. | ||
| Line 13: | Line 13: | ||
===High NC ratio in cancer=== | ===High NC ratio in cancer=== | ||
The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the ''[[small round cell tumour]]'' group. | The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the large ''[[small round cell tumour]]'' group. | ||
*Many other tumours. | *Many other tumours - see ''[[A long differential diagnosis of small blue cell tumours]]''. | ||
===Atypical cells with a normal NC ratio=== | ===Atypical cells with a normal NC ratio=== | ||
*[[Radiation changes]]. | *[[Radiation changes]] - [[clinical history]] is important! | ||
*Many tumours. | |||
==See also== | ==See also== | ||
Revision as of 12:29, 8 October 2013
Nucleus-to-cytoplasm ratio, also nuclear-cytoplasmic ratio, is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated NC ratio.
High NC ratio is strong predictor of malignancy.[1] Like very rule, there are exceptions.
High NC ratio in normal cells
- Lymphocytes.
Low NC ratio in cancer
- Fibrolamellar hepatocellular carcinoma.
- Acinic cell carcinoma.
- Many others.
High NC ratio in cancer
The classic malignant high NC ratio cell is small cell carcinoma, which is in the large small round cell tumour group.
- Many other tumours - see A long differential diagnosis of small blue cell tumours.
Atypical cells with a normal NC ratio
- Radiation changes - clinical history is important!
- Many tumours.
See also
References
- ↑ Mehrotra, R.; Gupta, A.; Singh, M.; Ibrahim, R. (2006). "Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions.". Mol Cancer 5: 11. doi:10.1186/1476-4598-5-11. PMID 16556320.