Difference between revisions of "Collecting duct carcinoma"

From Libre Pathology
Jump to navigation Jump to search
(split-out)
(+infobox)
Line 1: Line 1:
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Micro      = tubular structures with tapered ends, [[hobnail pattern]], nuclear pleomorphism), high mitotic rate
| Subtypes  =
| LMDDx      = [[papillary renal cell carcinoma]] (type 2), [[urothelial carcinoma]] (with glandular differentiation), metastatic [[adenocarcinoma]], [[renal medullary carcinoma]]
| Stains    =
| IHC        = CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[kidney]] - see [[kidney tumours]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = poor
| Other      =
| ClinDDx    = other [[renal tumours]]
}}
'''Collecting duct carcinoma''', also known as '''Bellini duct carcinoma'''<ref name=pmid21393935>{{Cite journal  | last1 = Stamatiou | first1 = K. | last2 = Zizi-Sermpetzoglou | first2 = A. | title = Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 229-30 | month =  | year =  | doi = 10.4103/0377-4929.77425 | PMID = 21393935 }}</ref> and '''carcinoma of the collecting ducts of Bellini''', is a rare aggressive [[kidney tumour]].
'''Collecting duct carcinoma''', also known as '''Bellini duct carcinoma'''<ref name=pmid21393935>{{Cite journal  | last1 = Stamatiou | first1 = K. | last2 = Zizi-Sermpetzoglou | first2 = A. | title = Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 229-30 | month =  | year =  | doi = 10.4103/0377-4929.77425 | PMID = 21393935 }}</ref> and '''carcinoma of the collecting ducts of Bellini''', is a rare aggressive [[kidney tumour]].


Line 4: Line 33:
*Rare.
*Rare.
*Poor prognosis.
*Poor prognosis.
*Usu. central location.
*Usually central location.
*Typically young adults.
*Typically young adults.


Line 42: Line 71:
UCC:
UCC:
*CK20 +ve.<ref name=pmid19494850/>
*CK20 +ve.<ref name=pmid19494850/>
*p63 +ve.
*p63 +ve.<ref name=pmid20463571>{{Cite journal  | last1 = Albadine | first1 = R. | last2 = Schultz | first2 = L. | last3 = Illei | first3 = P. | last4 = Ertoy | first4 = D. | last5 = Hicks | first5 = J. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | last8 = Netto | first8 = GJ. | title = PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. | journal = Am J Surg Pathol | volume = 34 | issue = 7 | pages = 965-9 | month = Jul | year = 2010 | doi = 10.1097/PAS.0b013e3181dc5e8a | PMID = 20463571 }}</ref>
*CK5/6 +ve.
*CK5/6 +ve.
*PAX8 -ve.<ref name=pmid20463571/>


Others:
Others:

Revision as of 03:45, 4 November 2013

Collecting duct carcinoma
Diagnosis in short
LM tubular structures with tapered ends, hobnail pattern, nuclear pleomorphism), high mitotic rate
LM DDx papillary renal cell carcinoma (type 2), urothelial carcinoma (with glandular differentiation), metastatic adenocarcinoma, renal medullary carcinoma
IHC CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve
Site kidney - see kidney tumours
Prevalence very rare
Prognosis poor
Clin. DDx other renal tumours

Collecting duct carcinoma, also known as Bellini duct carcinoma[1] and carcinoma of the collecting ducts of Bellini, is a rare aggressive kidney tumour.

General

  • Rare.
  • Poor prognosis.
  • Usually central location.
  • Typically young adults.

Microscopic

Features:[2]

  • Tubular structures with tapered ends.
    • May be described as tubulopapillary.
  • Hobnail pattern - cell width smaller at basement membrane than free surface.[3]
  • High grade nuclear features (nuclear pleomorphism).
  • High mitotic rate.

Notes:

  • Benign urothelium must present to excluded urothelial carcinoma.
  • Desmoplastic stroma may be prominent.

DDx:

Images

www:

IHC

Features:[5]

  • HMWCK +ve.
  • LMWCK +ve.
  • CD117 +ve.
  • E-cadherin +ve.
  • CD10 -ve.
  • AMACR -ve.

UCC:

  • CK20 +ve.[5]
  • p63 +ve.[6]
  • CK5/6 +ve.
  • PAX8 -ve.[6]

Others:

See also

References

  1. ↑ Stamatiou, K.; Zizi-Sermpetzoglou, A.. "Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis.". Indian J Pathol Microbiol 54 (1): 229-30. doi:10.4103/0377-4929.77425. PMID 21393935.
  2. ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 295. ISBN 978-0443066771.
  3. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1018. ISBN 0-7216-0187-1.
  4. ↑ Prasad, SR.; Humphrey, PA.; Catena, JR.; Narra, VR.; Srigley, JR.; Cortez, AD.; Dalrymple, NC.; Chintapalli, KN.. "Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation.". Radiographics 26 (6): 1795-806; discussion 1806-10. doi:10.1148/rg.266065010. PMID 17102051.
  5. ↑ 5.0 5.1 Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
  6. ↑ 6.0 6.1 Albadine, R.; Schultz, L.; Illei, P.; Ertoy, D.; Hicks, J.; Sharma, R.; Epstein, JI.; Netto, GJ. (Jul 2010). "PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract.". Am J Surg Pathol 34 (7): 965-9. doi:10.1097/PAS.0b013e3181dc5e8a. PMID 20463571.
  7. ↑ Kim, MK.; Kim, S. (Dec 2002). "Immunohistochemical profile of common epithelial neoplasms arising in the kidney.". Appl Immunohistochem Mol Morphol 10 (4): 332-8. PMID 12613443.
Retrieved from "https://librepathology.org/w/index.php?title=Collecting_duct_carcinoma&oldid=25486"