Difference between revisions of "Neurodegenerative diseases"
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**Alpha-synuclein is implicated in a number of neurodegenerative diseases.<ref name=pmid18855701>{{Cite journal | last1 = Uversky | first1 = VN. | title = Alpha-synuclein misfolding and neurodegenerative diseases. | journal = Curr Protein Pept Sci | volume = 9 | issue = 5 | pages = 507-40 | month = Oct | year = 2008 | doi = | PMID = 18855701 }}</ref> | **Alpha-synuclein is implicated in a number of neurodegenerative diseases.<ref name=pmid18855701>{{Cite journal | last1 = Uversky | first1 = VN. | title = Alpha-synuclein misfolding and neurodegenerative diseases. | journal = Curr Protein Pept Sci | volume = 9 | issue = 5 | pages = 507-40 | month = Oct | year = 2008 | doi = | PMID = 18855701 }}</ref> | ||
==Progressive supranuclear palsy== | |||
===General=== | |||
*[[AKA]] ''Steele-Richardson-Olszewski syndrome''. | |||
*Diagnosis: clinical.<ref name=psp_emedicine>URL: [http://emedicine.medscape.com/article/1151430-overview http://emedicine.medscape.com/article/1151430-overview]. Accessed on: 11 November 2010.</ref> | |||
===Microscopic=== | |||
Features: | |||
*Neurofibrillary tangles.<ref name=pmid19233037>PMID 19233037.</ref><ref name=psp_emedicine>URL: [http://emedicine.medscape.com/article/1151430-overview http://emedicine.medscape.com/article/1151430-overview]. Accessed on: 11 November 2010.</ref> | |||
==Huntington disease== | ==Huntington disease== | ||
Revision as of 18:52, 11 November 2010
Neurodegenerative diseases is a big part of neuropathology.
General DDx of dementia
- Alzheimer's dementia.
- Vascular.
- multi-infarct dementia.
- Parkinson's associated dementia.
- Lewy body dementia.
- Alcohol-related dementia.
- Fronto-temporal dementia (Pick disease).
- Multisystem atrophy.
Mnemonic VITAMIN D VEST:[1]
- Vitamin deficiency (B12, folate, thiamine).
- Infection (HIV).
- Trauma.
- Anoxia.
- Metabolic (Diabetes).
- Intracranial tumour.
- Normal pressure hydrocephalus.
- Degenerative (Alzheimer's, Huntington's, CJD).
- Vascular.
- Endocrine.
- Space occupying lesion (chronic subdural hematoma).
- Toxins (alcohol).
Lewy body dementia
- Parkinsonian features.
- Hallucinations (visual).
- Progressive cog. decline with fluctuations.
Multiple system atrophy
- Alpha-synuclein-rich glial cytoplasmic inclusions - finding at autopsy.[2]
- Alpha-synuclein is implicated in a number of neurodegenerative diseases.[3]
Progressive supranuclear palsy
General
Microscopic
Features:
Huntington disease
General
- Autosomal dominant inheritance.
- Mutation: unstable CAG repeat.[6]
Gross
- Missing caudate.[7]
Image: Huntington's disease (ouhsc.edu).
See also
References
- ↑ TN06 PS19
- ↑ Wenning, GK.; Stefanova, N.; Jellinger, KA.; Poewe, W.; Schlossmacher, MG. (Sep 2008). "Multiple system atrophy: a primary oligodendrogliopathy.". Ann Neurol 64 (3): 239-46. doi:10.1002/ana.21465. PMID 18825660.
- ↑ Uversky, VN. (Oct 2008). "Alpha-synuclein misfolding and neurodegenerative diseases.". Curr Protein Pept Sci 9 (5): 507-40. PMID 18855701.
- ↑ 4.0 4.1 URL: http://emedicine.medscape.com/article/1151430-overview. Accessed on: 11 November 2010.
- ↑ PMID 19233037.
- ↑ Kumar P, Kalonia H, Kumar A (2010). "Huntington's disease: pathogenesis to animal models". Pharmacol Rep 62 (1): 1–14. PMID 20360611.
- ↑ URL: http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm. Accessed on: 29 October 2010.