Difference between revisions of "Papillary urothelial hyperplasia"
Jump to navigation
Jump to search
| Line 4: | Line 4: | ||
*Benign. | *Benign. | ||
*Strong association with papillary neoplasms. | *Strong association with papillary neoplasms. | ||
**On follow-up | **On follow-up (in one study) >1/4, without prior history of urothelial neoplasia, have urothelial carcinoma; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | ||
*Inflammation. | *Inflammation. | ||
*Rare | *Rare papillary structures. | ||
**Do not have a well-developed fibrovascular core. | **Do not have a well-developed fibrovascular core. | ||
*No urothelial cell atypia. | *No urothelial cell atypia. | ||
DDx: | DDx: | ||
*[[Low-grade papillary urothelial carcinoma]]. | *[[Low-grade papillary urothelial carcinoma]] - have well-developed fibrovascular core. | ||
*[[PUNLMP]]. | *[[PUNLMP]]. | ||
*[[Urothelial papilloma]]. | *[[Urothelial papilloma]] - well-developed fibrovascular cores, uniform urothelial thickness. | ||
===Image=== | ===Image=== | ||
| Line 33: | Line 33: | ||
The urothelium stains as follow: | The urothelium stains as follow: | ||
CK7: positive ( | CK7: positive, patchy (normal). | ||
CK20: | CK20: only rare superficial cells (normal). | ||
Ki-67: rare, focally increased, negative in papillary structures (<10%). | Ki-67: rare, focally increased, negative in papillary structures (<10%). | ||
p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). | p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). | ||
Revision as of 19:32, 27 January 2014
Papillary urothelial hyperplasia is a benign lesion of the urothelium that is associated with the subsequent development of low-grade papillary urothelial carcinoma.
General
- Benign.
- Strong association with papillary neoplasms.
- On follow-up (in one study) >1/4, without prior history of urothelial neoplasia, have urothelial carcinoma; thus, follow-up is recommended.[1]
Microscopic
Features:[2]
- Inflammation.
- Rare papillary structures.
- Do not have a well-developed fibrovascular core.
- No urothelial cell atypia.
DDx:
- Low-grade papillary urothelial carcinoma - have well-developed fibrovascular core.
- PUNLMP.
- Urothelial papilloma - well-developed fibrovascular cores, uniform urothelial thickness.
Image
Sign out
URINARY BLADDER, BIOPSY: - REACTIVE PAPILLARY HYPERPLASIA, SEE COMMENT. - NO MUSCULARIS PROPRIA IDENTIFIED. - CYSTITIS CYSTICA ET GLANDULARIS. - NO EVIDENCE OF MALIGNANCY. COMMENT: The urothelial forms rare papillary structures; these are interpreted as reactive. The urothelium stains as follow: CK7: positive, patchy (normal). CK20: only rare superficial cells (normal). Ki-67: rare, focally increased, negative in papillary structures (<10%). p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). Follow-up is recommended.
See also
References
- ↑ Readal, N.; Epstein, JI. (Jun 2010). "Papillary urothelial hyperplasia: relationship to urothelial neoplasms.". Pathology 42 (4): 360-3. doi:10.3109/00313021003767322. PMID 20438409.
- ↑ URL: http://pathology.jhu.edu/bladder/definitions.cfm. Accessed on: 27 January 2014.