Difference between revisions of "Lhermitte-Duclos disease"
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*+/-Microcalcifications. | *+/-Microcalcifications. | ||
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Image:Dysplastic gangliocytoma lhermitte duclos.jpg | LDD. (WC/Jensflorian) | |||
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www: | |||
*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)]. | ||
Revision as of 14:51, 17 October 2014
Lhermitte-Duclos_disease, abbreviated LDD, is a rare neuropathology.
It is also known as dysplastic cerebellar gangliocytoma[1] and dysplastic gangliocytoma of the cerebellum.
General
- Cerebellar lesion.
- May be associated with Cowden syndrome.[2]
Microscopic
Features:[3]
- The outer (molecular) layer has increased cellularity.
- Purkinje cells absent.[1]
- Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - key feature.
- +/-Microcalcifications.
Images
LDD. (WC/Jensflorian)
www:
See also
References
- ↑ 1.0 1.1 Yağci-Küpeli, B.; Oguz, KK.; Bilen, MA.; Yalçin, B.; Akalan, N.; Büyükpamukçu, M. (Mar 2010). "An unusual cause of posterior fossa mass: Lhermitte-Duclos disease.". J Neurol Sci 290 (1-2): 138-41. doi:10.1016/j.jns.2009.12.010. PMID 20060133.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 158350
- ↑ URL: http://path.upmc.edu/cases/case472.html. Accessed on: 21 January 2012.