Difference between revisions of "Solitary fibrous tumour of the pleura"

From Libre Pathology
Jump to navigation Jump to search
(+infobox)
Line 1: Line 1:
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Pleural solitary fibrous tumor (2).jpg
| Width      =
| Caption    = Pleural solitary fibrous tumour. [[H&E stain]].
| Synonyms  =
| Micro      = spindle cells usually with a bland cytology, patternless pattern, +/-ropy collagen
| Subtypes  =
| LMDDx      = CD34 +ve, CD99 +ve, BCL2 +ve, S-100 -ve
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = pleura of [[lung]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      = +/-impaired respiratory function (due to mass effect)
| Symptoms  =
| Prevalence = common for site, uncommon overall
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = usu. benign
| Other      =
| ClinDDx    =
| Tx        = surgery
}}
'''Solitary fibrous tumour of the pleura''', also '''pleural solitary fibrous tumour''', is a relatively common chest wall tumour.
'''Solitary fibrous tumour of the pleura''', also '''pleural solitary fibrous tumour''', is a relatively common chest wall tumour.


Revision as of 03:37, 18 February 2014

Solitary fibrous tumour of the pleura
Diagnosis in short

Pleural solitary fibrous tumour. H&E stain.
LM spindle cells usually with a bland cytology, patternless pattern, +/-ropy collagen
LM DDx CD34 +ve, CD99 +ve, BCL2 +ve, S-100 -ve
Site pleura of lung
Signs +/-impaired respiratory function (due to mass effect)
Prevalence common for site, uncommon overall
Prognosis usu. benign
Treatment surgery

Solitary fibrous tumour of the pleura, also pleural solitary fibrous tumour, is a relatively common chest wall tumour.

The solitary fibrous tumour in general is dealt with in the solitary fibrous tumour article.

General

  • Uncommon overall.[1]
    • Common for the anatomical site.
  • Usually benign.
  • Slow growing.[1]
  • Elderly.
  • May be large - impair respiratory function.[2]

Gross/radiology

  • Chest wall.

Microscopic

Features:

  • Spindle cells - usually bland cytology.
  • Patternless pattern.
  • +/-Ropy collagen.

Suggestive of malignant:[2]

  • Mitotic rate >4/10 HPF.

DDx:

Images

  • Pleural SFT. (WC)

  • Pleural SFT. (WC)

  • Pleural SFT. (WC)

www:

IHC

Features:

  • CD34 +ve (19/23 cases[3]).
  • Ki-67 low (<5%).[2]
  • Vimentin +ve (23/23 cases[3]).
  • BCL2 +ve (23/23 cases[3]).
  • CD99 +ve (23/23 cases[3]).
  • SMA -ve/+ve (7 +ve/23 cases[3]).

Suggested stains:[citation needed]

  • CD34, CD99, BCL2, S-100, Ki-67.

Sign out

LEFT LUNG ("LARGE PLEURAL BASED MASS"), BIOPSY:
- SOLITARY FIBROUS TUMOUR.

Micro

The sections show cellular fibrous tissue with a patternless pattern. No mitotic activity is readily apparent. No significant nuclear atypia is identified. No necrosis is apparent.

See also

References

  1. ↑ 1.0 1.1 Mordenti, P.; Di Cicilia, R.; Delfanti, R.; Capelli, P.; Paties, C.; Cavanna, L.. "Solitary fibrous tumors of the pleura: a case report and review of the literature.". Tumori 99 (4): e177-83. doi:10.1700/1361.15120. PMID 24326857.
  2. ↑ 2.0 2.1 2.2 Abe, M.; Nomori, H.; Fukazawa, M.; Sugimura, H.; Narita, M.; Takeshi, A. (Oct 2013). "Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases.". Ann Thorac Cardiovasc Surg. PMID 24088920.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Chen, HJ.; Zhang, HY.; Li, X.; Guo, LX.; Wei, B.; Guo, H.; Bu, H.; Yang, K. et al. (Sep 2004). "[Solitary fibrous tumor: the clinicopathologic and immunohistochemical characteristics of 26 cases].". Sichuan Da Xue Xue Bao Yi Xue Ban 35 (5): 675-9. PMID 15460417.
Retrieved from "https://librepathology.org/w/index.php?title=Solitary_fibrous_tumour_of_the_pleura&oldid=29601"