Difference between revisions of "Solitary fibrous tumour of the pleura"
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| Site = pleura of [[lung]] | | Site = pleura of [[lung]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = Doege-Potter syndrome | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = +/-impaired respiratory function (due to mass effect) | | Signs = +/-impaired respiratory function (due to mass effect) | ||
| Line 41: | Line 41: | ||
*Elderly. | *Elderly. | ||
*May be large - impair respiratory function.<ref name=pmid24088920>{{Cite journal | last1 = Abe | first1 = M. | last2 = Nomori | first2 = H. | last3 = Fukazawa | first3 = M. | last4 = Sugimura | first4 = H. | last5 = Narita | first5 = M. | last6 = Takeshi | first6 = A. | title = Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases. | journal = Ann Thorac Cardiovasc Surg | volume = | issue = | pages = | month = Oct | year = 2013 | doi = | PMID = 24088920 }}</ref> | *May be large - impair respiratory function.<ref name=pmid24088920>{{Cite journal | last1 = Abe | first1 = M. | last2 = Nomori | first2 = H. | last3 = Fukazawa | first3 = M. | last4 = Sugimura | first4 = H. | last5 = Narita | first5 = M. | last6 = Takeshi | first6 = A. | title = Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases. | journal = Ann Thorac Cardiovasc Surg | volume = | issue = | pages = | month = Oct | year = 2013 | doi = | PMID = 24088920 }}</ref> | ||
*May be associated with hypoglycemia. | |||
**Known as ''Doege-Potter syndrome''.<ref name=pmid1474302>{{Cite journal | last1 = Roy | first1 = TM. | last2 = Burns | first2 = MV. | last3 = Overly | first3 = DJ. | last4 = Curd | first4 = BT. | title = Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome. | journal = J Ky Med Assoc | volume = 90 | issue = 11 | pages = 557-60 | month = Nov | year = 1992 | doi = | PMID = 1474302 }}</ref> | |||
==Gross/radiology== | ==Gross/radiology== | ||
*Chest wall. | *Chest wall mass. | ||
==Microscopic== | ==Microscopic== | ||
Revision as of 03:39, 18 February 2014
| Solitary fibrous tumour of the pleura | |
|---|---|
| Diagnosis in short | |
.jpg) Pleural solitary fibrous tumour. H&E stain. | |
|
| |
| LM | spindle cells usually with a bland cytology, patternless pattern, +/-ropy collagen |
| LM DDx | CD34 +ve, CD99 +ve, BCL2 +ve, S-100 -ve |
| Site | pleura of lung |
|
| |
| Syndromes | Doege-Potter syndrome |
|
| |
| Signs | +/-impaired respiratory function (due to mass effect) |
| Prevalence | common for site, uncommon overall |
| Prognosis | usu. benign |
| Treatment | surgery |
Solitary fibrous tumour of the pleura, also pleural solitary fibrous tumour, is a relatively common chest wall tumour.
The solitary fibrous tumour in general is dealt with in the solitary fibrous tumour article.
General
- Uncommon overall.[1]
- Common for the anatomical site.
- Usually benign.
- Slow growing.[1]
- Elderly.
- May be large - impair respiratory function.[2]
- May be associated with hypoglycemia.
- Known as Doege-Potter syndrome.[3]
Gross/radiology
- Chest wall mass.
Microscopic
Features:
- Spindle cells - usually bland cytology.
- Patternless pattern.
- +/-Ropy collagen.
Suggestive of malignant:[2]
- Mitotic rate >4/10 HPF.
- Definition suffers from HPFitis.
DDx:
- Malignant mesothelioma.
- Metastatic carcinoma.
- Lung adenocarcinoma.
Images
Pleural SFT. (WC)
Pleural SFT. (WC)
Pleural SFT. (WC)
.jpg)
.jpg)
www:
IHC
Features:
- CD34 +ve (19/23 cases[4]).
- Ki-67 low (<5%).[2]
- Vimentin +ve (23/23 cases[4]).
- BCL2 +ve (23/23 cases[4]).
- CD99 +ve (23/23 cases[4]).
- SMA -ve/+ve (7 +ve/23 cases[4]).
Suggested stains:[citation needed]
- CD34, CD99, BCL2, S-100, Ki-67.
Sign out
LEFT LUNG ("LARGE PLEURAL BASED MASS"), BIOPSY:
- SOLITARY FIBROUS TUMOUR.
Micro
The sections show cellular fibrous tissue with a patternless pattern. No mitotic activity is readily apparent. No significant nuclear atypia is identified. No necrosis is apparent.
See also
References
- ↑ 1.0 1.1 Mordenti, P.; Di Cicilia, R.; Delfanti, R.; Capelli, P.; Paties, C.; Cavanna, L.. "Solitary fibrous tumors of the pleura: a case report and review of the literature.". Tumori 99 (4): e177-83. doi:10.1700/1361.15120. PMID 24326857.
- ↑ 2.0 2.1 2.2 Abe, M.; Nomori, H.; Fukazawa, M.; Sugimura, H.; Narita, M.; Takeshi, A. (Oct 2013). "Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases.". Ann Thorac Cardiovasc Surg. PMID 24088920.
- ↑ Roy, TM.; Burns, MV.; Overly, DJ.; Curd, BT. (Nov 1992). "Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome.". J Ky Med Assoc 90 (11): 557-60. PMID 1474302.
- ↑ 4.0 4.1 4.2 4.3 4.4 Chen, HJ.; Zhang, HY.; Li, X.; Guo, LX.; Wei, B.; Guo, H.; Bu, H.; Yang, K. et al. (Sep 2004). "[Solitary fibrous tumor: the clinicopathologic and immunohistochemical characteristics of 26 cases].". Sichuan Da Xue Xue Bao Yi Xue Ban 35 (5): 675-9. PMID 15460417.