Difference between revisions of "Craniopharyngioma"

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#redirect [[Pituitary gland#Craniopharyngioma]]
'''Craniopharyngioma''' is a benign [[neuropathology tumour]].
 
==General==
*Develop from remains of Rathke's pouch or squamous epithelial cell rests.<ref name=pmid17425791>{{Cite journal  | last1 = Garnett | first1 = MR. | last2 = Puget | first2 = S. | last3 = Grill | first3 = J. | last4 = Sainte-Rose | first4 = C. | title = Craniopharyngioma. | journal = Orphanet J Rare Dis | volume = 2 | issue =  | pages = 18 | month =  | year = 2007 | doi = 10.1186/1750-1172-2-18 | PMID = 17425791 }}</ref>
 
Comes in two flavours:<ref name=pmid17425791/>
*Adamantinomatous type.
**Adults and children. 
*Squamous papillary type.
**Adults individuals.<ref name=pmid6696166>{{Cite journal  | last1 = Giangaspero | first1 = F. | last2 = Burger | first2 = PC. | last3 = Osborne | first3 = DR. | last4 = Stein | first4 = RB. | title = Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma"). | journal = Am J Surg Pathol | volume = 8 | issue = 1 | pages = 57-64 | month = Jan | year = 1984 | doi =  | PMID = 6696166 }}</ref>
**Usually solid.
 
Radiology:<ref name=pmid17425791/>
*Calcified - adamantinomatous type only.
*Solid & cystic.
 
==Microscopic==
===Adamantinomatous===
Features (adamantinomatous):<ref name=Ref_DCHH184>{{Ref DCHH|184}}</ref>
*Well-circumscribed (or pseudoinvasive border).
*Multicystic.
*Small-to-medium sized cells with moderate amount of basophilic cytoplasm.
*Bland nuclei (with occ. small nucleoli).
*"Wet" keratin - nests of whorled keratin.
*Calcifications (non-psammomatous).
 
====Images====
<gallery>
Image:Adamantinomatous_craniopharyngioma_-_very_low_mag.jpg | Adamantinomatous craniopharyngioma - very low mag. (WC/Nephron)
Image:Adamantinomatous_craniopharyngioma_-_intermed_mag.jpg | Adamantinomatous craniopharyngioma - intermed. mag. (WC/Nephron)
Image:Adamantinomatous_craniopharyngioma_-_very_high_mag.jpg | Adamantinomatous craniopharyngioma - very high mag. (WC/Nephron)
</gallery>
===Papillary===
Features (papillary):<ref name=Ref_PSNP406>{{Ref PSNP|406}}</ref>
*Non-keratinized squamous epithelium (without nuclear atypia).
*Fibrovascular cores (required for ''papillary'').
 
Notes:
*+/-Cilia (rare).
*+/-Goblet cell-like formations (rare).
 
====Image====
<gallery>
Image:Papillary_craniopharyngioma_-_intermed_mag.jpg |Papillary craniopharyngioma - intermed. mag. (WC/Nephron)
Image:Papillary_craniopharyngioma_-_very_high_mag.jpg |Papillary craniopharyngioma - very high mag. (WC/Nephron)
</gallery>
www:
*[http://library.med.utah.edu/WebPath/jpeg4/ENDO115.jpg Craniopharyngioma (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/jpeg4/ENDO115.jpg http://library.med.utah.edu/WebPath/jpeg4/ENDO115.jpg]. Accessed on: 6 December 2010.</ref>
 
==See also==
*[[Pituitary gland]].
*[[Neuropathology tumours]].
 
==References==
{{Reflist|2}}
 
[[Category:Neuropathology]]

Revision as of 21:09, 11 November 2013

Craniopharyngioma is a benign neuropathology tumour.

General

  • Develop from remains of Rathke's pouch or squamous epithelial cell rests.[1]

Comes in two flavours:[1]

  • Adamantinomatous type.
    • Adults and children.
  • Squamous papillary type.
    • Adults individuals.[2]
    • Usually solid.

Radiology:[1]

  • Calcified - adamantinomatous type only.
  • Solid & cystic.

Microscopic

Adamantinomatous

Features (adamantinomatous):[3]

  • Well-circumscribed (or pseudoinvasive border).
  • Multicystic.
  • Small-to-medium sized cells with moderate amount of basophilic cytoplasm.
  • Bland nuclei (with occ. small nucleoli).
  • "Wet" keratin - nests of whorled keratin.
  • Calcifications (non-psammomatous).

Images

  • Adamantinomatous craniopharyngioma - very low mag. (WC/Nephron)

  • Adamantinomatous craniopharyngioma - intermed. mag. (WC/Nephron)

  • Adamantinomatous craniopharyngioma - very high mag. (WC/Nephron)

Papillary

Features (papillary):[4]

  • Non-keratinized squamous epithelium (without nuclear atypia).
  • Fibrovascular cores (required for papillary).

Notes:

  • +/-Cilia (rare).
  • +/-Goblet cell-like formations (rare).

Image

  • Papillary craniopharyngioma - intermed. mag. (WC/Nephron)

  • Papillary craniopharyngioma - very high mag. (WC/Nephron)

www:

See also

References

  1. ↑ 1.0 1.1 1.2 Garnett, MR.; Puget, S.; Grill, J.; Sainte-Rose, C. (2007). "Craniopharyngioma.". Orphanet J Rare Dis 2: 18. doi:10.1186/1750-1172-2-18. PMID 17425791.
  2. ↑ Giangaspero, F.; Burger, PC.; Osborne, DR.; Stein, RB. (Jan 1984). "Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma").". Am J Surg Pathol 8 (1): 57-64. PMID 6696166.
  3. ↑ Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 184. ISBN 978-0470519035.
  4. ↑ Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 406. ISBN 978-0443069826.
  5. ↑ URL: http://library.med.utah.edu/WebPath/jpeg4/ENDO115.jpg. Accessed on: 6 December 2010.
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