Difference between revisions of "Adenocarcinoma of the urinary bladder"
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*CDX2 +ve (strong, diffuse). | *CDX2 +ve (strong, diffuse). | ||
*Beta-catenin +ve (membranous, not nuclear). | *Beta-catenin +ve (membranous, not nuclear). | ||
**[[Colorectal adenocarcinoma]] | **[[Colorectal adenocarcinoma]] typically has nuclear staining ''and'' membranous staining. | ||
*Thrombomodulin +ve/-ve (~60% of cases). | *Thrombomodulin +ve/-ve (~60% of cases). | ||
**[[Colorectal adenocarcinoma]] -ve. | **[[Colorectal adenocarcinoma]] -ve. | ||
Revision as of 12:21, 15 April 2014
Adenocarcinoma of the urinary bladder, also primary adenocarcinoma of the urinary bladder and bladder adenocarcinoma, is a very uncommon malignant bladder tumour.
General
- Very rare.[1]
Clinical:
- Like urothelial carcinoma - usu. hematuria.[1]
Microscopic
Features:
- Nuclear pleomorphism.
- Glandular differentiation.
- No urothelial differentiation - important.[2]
DDx:
- Urachal carcinoma - dome of bladder.
- Invasive urothelial carcinoma with glandular differentiation - has urothelial differentiation.
- Metastatic adenocarcinoma.
IHC
Features - variable:[3]
- CK7 +ve.
- CK20 +ve.
- CDX2 +ve (strong, diffuse).
- Beta-catenin +ve (membranous, not nuclear).
- Colorectal adenocarcinoma typically has nuclear staining and membranous staining.
- Thrombomodulin +ve/-ve (~60% of cases).
- Colorectal adenocarcinoma -ve.
- Urothelial carcinoma +ve (~90% of cases).
See also
References
- ↑ 1.0 1.1 Ranadive, NU.; Trivedi, VD.; Gadgil, NM. (Oct 1999). "Primary adenocarcinoma of the urinary bladder: a study of 6 cases from the pathologist's point of view.". Arch Esp Urol 52 (8): 906-11. PMID 11762445.
- ↑ Zhong, M.; Gersbach, E.; Rohan, SM.; Yang, XJ. (Mar 2013). "Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.". Arch Pathol Lab Med 137 (3): 371-81. doi:10.5858/arpa.2012-0076-RA. PMID 23451748.
- ↑ Roy, S.; Parwani, AV. (Dec 2011). "Adenocarcinoma of the urinary bladder.". Arch Pathol Lab Med 135 (12): 1601-5. doi:10.5858/arpa.2009-0713-RS. PMID 22129192.