Difference between revisions of "Nasal polyps"
Jump to navigation
Jump to search
(split out) |
|||
| Line 145: | Line 145: | ||
*May mimic invasive SCC. | *May mimic invasive SCC. | ||
Images | =====Images===== | ||
*[http://path.upmc.edu/cases/case32.html Inverted papilloma & verrucous carcinoma (upmc.edu)]. | *[http://path.upmc.edu/cases/case32.html Inverted papilloma & verrucous carcinoma (upmc.edu)]. | ||
<gallery> | |||
Image:Sinonasal_papilloma_-_very_low_mag.jpg | Schneiderian papilloma - very low mag. (WC) | |||
Image:Sinonasal_papilloma_-_cropped_-_very_high_mag.jpg | Schneiderian papilloma - very high mag. (WC) | |||
</gallery> | |||
====Fungiform Schneiderian papilloma==== | ====Fungiform Schneiderian papilloma==== | ||
Revision as of 06:22, 27 July 2014
Nasal polyps are a common head and neck lesion. They are typically benign but may be malignant.
Overview
DDx (benign - multiple):[1]
- Autoimmune/idiopathic:
- Asthma.
- Allergic rhinitis.
- Churg-Strauss syndrome (AKA allergic granulomatous angiitis).
- Features: asthma, eosinophilia, granulomatous inflammation, necrotizing systemic vasculitis, and necrotizing glomerulonephritis.[2]
- Nonallergic rhinitis with eosinophilia syndrome (NARES).
- Infectious:
- Fungal infection (with allergic component - AFS = allergic fungal sinusitis).
- Chronic rhinosinusitis.
- Genetic:
- Primary ciliary dyskinesia.
- Cystic fibrosis.
- Associations:
- Alcohol intolerance ~ 50%.
- Aspirin intolerance - upto ~ 25%.
- Tumours:
- Juvenile nasopharyngeal angiofibroma - young males.
- Nasopharyngeal carcinomas.
- Sarcomas.
- Hemangioma.
- Schneiderian papilloma.
- Other.
Memory devices:
- GAIT = Genetic, Allergic/idiopathic, Infectious, Tumours.
- Allergic causes As - allergic, asthma, allergic granulomatous angiitis (Churg-Strauss syndrome), nonallergic rhinitis with eosinophilia.
Epidemiology
- More commonly assoc. with nonallergic conditions.[1]
Treatment
- Recurrent polyps: functional endoscopic sinus surgery (FESS).
Inflammatory polyps with neutrophils
General
- Histologic findings are non-specific; DDx includes:[3]
- Cystic fibrosis.
- Primary ciliary dyskinesia syndrome.
- Young syndrome
Microscopic
Features:
- Neutrophil predominant.
- Edema.
- +/-Mucus-impaction (dilated glands with mucus).
- Suggestive of cystic fibrosis.[4]
Sign out
A. Nasal sinus tissue, right, excision: - Inflamed edematous sinonasal mucosa with abundant neutrophils. - Negative for malignancy. B. Nasal sinus tissue, left, excision: - Inflamed edematous sinonasal mucosa with abundant neutrophils and fragments of bone. - Negative for malignancy.
Allergic nasal polyp
General
- People with allergies.
- Same type of polyps seen in those without allergies.[5]
Gross
- Polypoid mass - several millimetres to centimetres in size.
- Translucent.[citation needed]
Microscopic
Features:[6]
- Normal respiratory epithelium.
- Stroma with:
- Edema.
- Eosinophils.
- +/-Other inflammatory cells (plasma cells, lymphocytes, neutrophils).
DDx:
- Inflammatory nasal polyp with abundant neutrophils.
- Vasculitis.
Sign out
A. Nasal sinus tissue, right, excision: - Inflamed edematous sinonasal mucosa with abundant eosinophils. - Negative for malignancy. B. Nasal sinus tissue, left, excision: - Inflamed edematous sinonasal mucosa with abundant eosinophils and fragments of bone. - Negative for malignancy.
A. NASAL SINUS TISSUE, RIGHT, EXCISION: - INFLAMED EDEMATOUS SINONASAL MUCOSA WITH ABUNDANT EOSINOPHILS. - NEGATIVE FOR MALIGNANCY. B. NASAL SINUS TISSUE, LEFT, EXCISION: - INFLAMED EDEMATOUS SINONASAL MUCOSA WITH ABUNDANT EOSINOPHILS AND FRAGMENTS OF BONE. - NEGATIVE FOR MALIGNANCY.
Tonsillar lymphangiomatous polyp
Microscopic
Features:[7]
- Polyp with lymph channels.
Schneiderian papilloma
General
- Lumpers vs. splitters debate about whether it is one entity or three.[9]
- Inverted (Schneiderian) - most common ~60-65%.
- Fungiform (Schneiderian) - less common ~30-35%.
- Oncocytic (Schneiderian) - least common ~5%.
Inverted
- AKA inverted papilloma.[10]
- Usually lateral wall (as the septum as little soft tissue to grow into).[9]
- May transform to carcinoma.
Fungiform
Oncocytic
Microscopic
Inverted Schneiderian papilloma
Features:[9]
- Well-demarcated epithelial islands in the stroma.
- Squamous +/-surface keratinization or respiratory type epithelium (with cilia).
- +/-Neutrophils.
- +/-Goblet cells.
Notes:
- May mimic invasive SCC.
Images
Schneiderian papilloma - very low mag. (WC)
Schneiderian papilloma - very high mag. (WC)
Fungiform Schneiderian papilloma
Features:
- Exophytic growth pattern - key feature.
Oncocytic Schneiderian papilloma
Features:
- Oncocytes - key feature.
- Exophytic or endophytic growth pattern.
See also
References
- ↑ 1.0 1.1 URL: http://emedicine.medscape.com/article/994274-overview. Accessed on: 16 March 2011.
- ↑ http://emedicine.medscape.com/article/333492-overview
- ↑ URL: http://emedicine.medscape.com/article/994274-diagnosis. Accessed on: 16 March 2011.
- ↑ Beju D, Meek WD, Kramer JC (April 2004). "The ultrastructure of the nasal polyps in patients with and without cystic fibrosis". J. Submicrosc. Cytol. Pathol. 36 (2): 155–65. PMID 15554502.
- ↑ Davidsson, A.; Hellquist, HB. (1993). "The so-called 'allergic' nasal polyp.". ORL J Otorhinolaryngol Relat Spec 55 (1): 30-5. PMID 8441521.
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 144. ISBN 978-1416002741.
- ↑ http://www.nature.com/modpathol/journal/v13/n10/full/3880208a.html
- ↑ URL: http://emedicine.medscape.com/article/862677-overview. Accessed on: 19 November 2011.
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Barnes L (March 2002). "Schneiderian papillomas and nonsalivary glandular neoplasms of the head and neck". Mod. Pathol. 15 (3): 279–97. doi:10.1038/modpathol.3880524. PMID 11904343. http://www.nature.com/modpathol/journal/v15/n3/full/3880524a.html.
- ↑ Vrabec, DP. (May 1994). "The inverted Schneiderian papilloma: a 25-year study.". Laryngoscope 104 (5 Pt 1): 582-605. PMID 8189990.
- ↑ Bravo Domínguez, O.; Vela Cortina, M.; Ramírez Ruiz, RD.; Ros Vergara, A.; Dinarés Jaumeandreu, D.; Encina Ruiz, L.; Arias Cuchí, G.; Ardíaca Bosch, MC. et al. (2005). "[Oncocytic schneiderian papilloma. A case report].". An Otorrinolaringol Ibero Am 32 (2): 115-23. PMID 15929584.