Difference between revisions of "Adenocarcinoma of the urinary bladder"
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| Line 10: | Line 10: | ||
Features: | Features: | ||
*Nuclear pleomorphism - may be mild. | *Nuclear pleomorphism - may be mild. | ||
*Glandular differentiation | *Glandular differentiation - most common. | ||
**Frequently looks just like [[colorectal adenocarcinoma]]. | |||
*No urothelial differentiation - '''essential'''.<ref name=pmid23451748>{{Cite journal | last1 = Zhong | first1 = M. | last2 = Gersbach | first2 = E. | last3 = Rohan | first3 = SM. | last4 = Yang | first4 = XJ. | title = Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. | journal = Arch Pathol Lab Med | volume = 137 | issue = 3 | pages = 371-81 | month = Mar | year = 2013 | doi = 10.5858/arpa.2012-0076-RA | PMID = 23451748 }}</ref> | *No urothelial differentiation - '''essential'''.<ref name=pmid23451748>{{Cite journal | last1 = Zhong | first1 = M. | last2 = Gersbach | first2 = E. | last3 = Rohan | first3 = SM. | last4 = Yang | first4 = XJ. | title = Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance. | journal = Arch Pathol Lab Med | volume = 137 | issue = 3 | pages = 371-81 | month = Mar | year = 2013 | doi = 10.5858/arpa.2012-0076-RA | PMID = 23451748 }}</ref> | ||
Subtypes:<ref name=pmid23772302>{{Cite journal | last1 = Abbas | first1 = M. | last2 = Kramer | first2 = MW. | last3 = Wolters | first3 = M. | last4 = Herrman | first4 = TR. | last5 = Becker | first5 = JU. | last6 = Kreipe | first6 = HH. | title = Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case. | journal = Rare Tumors | volume = 5 | issue = 1 | pages = e3 | month = Feb | year = 2013 | doi = 10.4081/rt.2013.e3 | PMID = 23772302 }}</ref> | |||
*Glandular. | |||
*Papillary. | |||
*colloidal (mucinous). | |||
*Signet ring cell carcinoma. | |||
*Clear cell carcinoma (also ''mesonephroid carcinoma''). | |||
DDx: | DDx: | ||
Revision as of 08:22, 19 December 2014
Adenocarcinoma of the urinary bladder, also primary adenocarcinoma of the urinary bladder and bladder adenocarcinoma, is a very uncommon malignant urinary bladder tumour.
General
- Very rare.[1]
Clinical:
- Like urothelial carcinoma - usu. hematuria.[1]
Microscopic
Features:
- Nuclear pleomorphism - may be mild.
- Glandular differentiation - most common.
- Frequently looks just like colorectal adenocarcinoma.
- No urothelial differentiation - essential.[2]
Subtypes:[3]
- Glandular.
- Papillary.
- colloidal (mucinous).
- Signet ring cell carcinoma.
- Clear cell carcinoma (also mesonephroid carcinoma).
DDx:
- Urachal carcinoma - dome of bladder.
- Invasive urothelial carcinoma with glandular differentiation - has urothelial differentiation.
- Metastatic adenocarcinoma.
IHC
Features - variable:[4]
- CK7 +ve.
- CK20 +ve.
- CDX2 +ve (strong, diffuse).
- Beta-catenin +ve (membranous, not nuclear).
- Colorectal adenocarcinoma typically has nuclear staining and membranous staining.
- Thrombomodulin +ve/-ve (~60% of cases).
- Colorectal adenocarcinoma -ve.
- Urothelial carcinoma +ve (~90% of cases).
See also
References
- ↑ 1.0 1.1 Ranadive, NU.; Trivedi, VD.; Gadgil, NM. (Oct 1999). "Primary adenocarcinoma of the urinary bladder: a study of 6 cases from the pathologist's point of view.". Arch Esp Urol 52 (8): 906-11. PMID 11762445.
- ↑ Zhong, M.; Gersbach, E.; Rohan, SM.; Yang, XJ. (Mar 2013). "Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.". Arch Pathol Lab Med 137 (3): 371-81. doi:10.5858/arpa.2012-0076-RA. PMID 23451748.
- ↑ Abbas, M.; Kramer, MW.; Wolters, M.; Herrman, TR.; Becker, JU.; Kreipe, HH. (Feb 2013). "Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case.". Rare Tumors 5 (1): e3. doi:10.4081/rt.2013.e3. PMID 23772302.
- ↑ Roy, S.; Parwani, AV. (Dec 2011). "Adenocarcinoma of the urinary bladder.". Arch Pathol Lab Med 135 (12): 1601-5. doi:10.5858/arpa.2009-0713-RS. PMID 22129192.