Difference between revisions of "Glomus tumour"
Jump to navigation
Jump to search
(→Other diagnoses...: wikify) |
(+images, +IHC) |
||
| Line 2: | Line 2: | ||
It should not be confused with ''[[paraganglioma]]'', which were once called glomus tumour. | It should not be confused with ''[[paraganglioma]]'', which were once called glomus tumour. | ||
==General== | |||
*Tumour derived from smooth muscle cell.<ref name=pmid18788860>{{cite journal |author=Gombos Z, Zhang PJ |title=Glomus tumor |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=9 |pages=1448–52 |year=2008 |month=September |pmid=18788860 |doi=10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2 |url=}}</ref> | |||
*Usually benign. | |||
**Malignant variant exists - extremely rare. | |||
Clinical: | |||
*[[Painful skin lesion]]. | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm]. Accessed on: 19 October 2010.</ref> | Features:<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm]. Accessed on: 19 October 2010.</ref> | ||
*Sheets of polygonal epithelioid cells with | *Sheets of equally-spaced polygonal epithelioid cells. | ||
**The regular spacing is called "cookie cutter" appearance. It looks like the cells were created with a cookie cutter; the spacing is equal and they all look very similar. | |||
*Thin-walled blood vessels. | |||
*No significant nuclear atypia. | *No significant nuclear atypia. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Glomus_tumour_-_intermed_mag.jpg Glomus tumour - intermed. mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Glomus_tumour_-_2_-_very_high_mag.jpg Glomus tumour - very high mag. (WC)]. | |||
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm Glomus tumour (ouhsc.edu)]. | *[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm Glomus tumour (ouhsc.edu)]. | ||
===IHC=== | |||
Features:<ref name=pmid9362106>{{cite journal |author=Hatori M, Aiba S, Kato M, Kamiya N, Kokubun S |title=Expression of CD34 in glomus tumors |journal=Tohoku J. Exp. Med. |volume=182 |issue=3 |pages=241–7 |year=1997 |month=July |pmid=9362106 |doi= |url=}}</ref> | |||
*SMA +ve ~ 100%. | |||
*Desmin usu. -ve. | |||
*CD34 -ve. | |||
**Rarely +ve. | |||
Others: | |||
*S100 -ve. | |||
===Other diagnoses... === | ===Other diagnoses... === | ||
| Line 15: | Line 37: | ||
*[[Angiosarcoma]] - has nuclear atypia. | *[[Angiosarcoma]] - has nuclear atypia. | ||
*[[Dermatofibroma]] - spindle cell lesion. | *[[Dermatofibroma]] - spindle cell lesion. | ||
*Capillary hemangioma - no epithelioid cells, more blood vessels. | *[[Capillary hemangioma]] - no epithelioid cells, more blood vessels. | ||
==See also== | ==See also== | ||
Revision as of 14:26, 15 April 2011
Glomus tumours, AKA glomangioma, are painful.
It should not be confused with paraganglioma, which were once called glomus tumour.
General
- Tumour derived from smooth muscle cell.[1]
- Usually benign.
- Malignant variant exists - extremely rare.
Clinical:
Microscopic
Features:[2]
- Sheets of equally-spaced polygonal epithelioid cells.
- The regular spacing is called "cookie cutter" appearance. It looks like the cells were created with a cookie cutter; the spacing is equal and they all look very similar.
- Thin-walled blood vessels.
- No significant nuclear atypia.
Images:
- Glomus tumour - intermed. mag. (WC).
- Glomus tumour - very high mag. (WC).
- Glomus tumour (ouhsc.edu).
IHC
Features:[3]
- SMA +ve ~ 100%.
- Desmin usu. -ve.
- CD34 -ve.
- Rarely +ve.
Others:
- S100 -ve.
Other diagnoses...
Why it is not a(n) ...[2]
- Angiosarcoma - has nuclear atypia.
- Dermatofibroma - spindle cell lesion.
- Capillary hemangioma - no epithelioid cells, more blood vessels.
See also
References
- ↑ Gombos Z, Zhang PJ (September 2008). "Glomus tumor". Arch. Pathol. Lab. Med. 132 (9): 1448–52. doi:10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2. PMID 18788860.
- ↑ 2.0 2.1 URL: http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm. Accessed on: 19 October 2010.
- ↑ Hatori M, Aiba S, Kato M, Kamiya N, Kokubun S (July 1997). "Expression of CD34 in glomus tumors". Tohoku J. Exp. Med. 182 (3): 241–7. PMID 9362106.