Difference between revisions of "Squamous cell carcinoma of the urinary bladder"
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| LMDDx = [[metastatic]] squamous cell carcinoma (esp. [[squamous cell carcinoma of the uterine cervix]]), [[urothelial carcinoma]] with squamous differentiation, | |||
[[condyloma acuminatum]], [[squamous dysplasia]] | |||
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| IHC = p16 -ve/+ve | |||
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| Site = [[urinary bladder]] | |||
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| Clinicalhx = lived in areas with ''Schistosoma haematobium'' | |||
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| Prevalence = very rare | |||
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'''Squamous cell carcinoma of the urinary bladder''', abbreviated '''SCC of the bladder''', is a rare [[cancer]] of the [[urinary bladder]]. | '''Squamous cell carcinoma of the urinary bladder''', abbreviated '''SCC of the bladder''', is a rare [[cancer]] of the [[urinary bladder]]. | ||
Revision as of 16:05, 16 June 2015
| Squamous cell carcinoma of the urinary bladder | |
|---|---|
| Diagnosis in short | |
| LM DDx |
metastatic squamous cell carcinoma (esp. squamous cell carcinoma of the uterine cervix), urothelial carcinoma with squamous differentiation, condyloma acuminatum, squamous dysplasia |
| IHC | p16 -ve/+ve |
| Site | urinary bladder |
|
| |
| Clinical history | lived in areas with Schistosoma haematobium |
| Prevalence | very rare |
Squamous cell carcinoma of the urinary bladder, abbreviated SCC of the bladder, is a rare cancer of the urinary bladder.
Squamous differentiation in urothelial carcinoma is common and much more frequent than SCC of the bladder.
General
- Strong association with Schistosoma haematobium.[1]
- Common in areas with S. haematobium.
- Uncommon in areas without S. haematobium.
Microscopic
Features:
- See squamous cell carcinoma article.
DDx:
- Metastatic squamous cell carcinoma.
- Urothelial carcinoma with squamous differentiation - very common.
- In biopsies, this should be mentioned as a possibility.
- Condyloma acuminatum.
- Squamous dysplasia.
IHC
Features:
- p16 -ve/+ve.
- Not definite for separating from cervix - but suggestive: cervix ~86% +ve, bladder ~37% +ve.[2]
See also
References
- ↑ Michaud, DS.. "Chronic inflammation and bladder cancer.". Urol Oncol 25 (3): 260-8. doi:10.1016/j.urolonc.2006.10.002. PMID 17483025.
- ↑ Cioffi-Lavina, M.; Chapman-Fredricks, J.; Gomez-Fernandez, C.; Ganjei-Azar, P.; Manoharan, M.; Jorda, M. (Jul 2010). "P16 expression in squamous cell carcinomas of cervix and bladder.". Appl Immunohistochem Mol Morphol 18 (4): 344-7. doi:10.1097/PAI.0b013e3181d2bbd7. PMID 20571342.