Difference between revisions of "Urinary bladder xanthoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = aggregate of foamy histiocytes in the lamina propria, no significant nuclear atypia | |||
| Subtypes = | |||
| LMDDx = [[signet ring cell carcinoma]], [[granular cell tumour]], [[malakoplakia]], [[xanthogranulomatous cystitis]], benign urothelium with mild atypia | |||
| Stains = | |||
| IHC = CD68 +ve, S-100 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[urinary bladder]] (elsewhere) | |||
| Assdx = lipid disorders (hyperlipidemia) | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = +/-hematuria | |||
| Symptoms = irritation | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = patch or plaque, yellow, ill-defined border | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Urinary bladder xanthoma''', also '''[[xanthoma]] of the [[urinary bladder]]''' and '''bladder xanthoma''', is a rare benign lesion of the bladder that occasionally may be clinically suspicious for [[malignancy]].<ref name=pmid24810457>{{Cite journal | last1 = Hassouna | first1 = H. | last2 = Broome | first2 = JD. | last3 = Swalem | first3 = K. | last4 = Manikandan | first4 = R. | title = Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy. | journal = BMJ Case Rep | volume = 2014 | issue = | pages = | month = | year = 2014 | doi = 10.1136/bcr-2014-203836 | PMID = 24810457 }}</ref> | '''Urinary bladder xanthoma''', also '''[[xanthoma]] of the [[urinary bladder]]''' and '''bladder xanthoma''', is a rare benign lesion of the bladder that occasionally may be clinically suspicious for [[malignancy]].<ref name=pmid24810457>{{Cite journal | last1 = Hassouna | first1 = H. | last2 = Broome | first2 = JD. | last3 = Swalem | first3 = K. | last4 = Manikandan | first4 = R. | title = Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy. | journal = BMJ Case Rep | volume = 2014 | issue = | pages = | month = | year = 2014 | doi = 10.1136/bcr-2014-203836 | PMID = 24810457 }}</ref> | ||
Revision as of 03:52, 23 July 2015
| Urinary bladder xanthoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | aggregate of foamy histiocytes in the lamina propria, no significant nuclear atypia |
| LM DDx | signet ring cell carcinoma, granular cell tumour, malakoplakia, xanthogranulomatous cystitis, benign urothelium with mild atypia |
| IHC | CD68 +ve, S-100 -ve |
| Site | urinary bladder (elsewhere) |
|
| |
| Associated Dx | lipid disorders (hyperlipidemia) |
| Signs | +/-hematuria |
| Symptoms | irritation |
| Prevalence | very rare |
| Endoscopy | patch or plaque, yellow, ill-defined border |
| Prognosis | benign |
Urinary bladder xanthoma, also xanthoma of the urinary bladder and bladder xanthoma, is a rare benign lesion of the bladder that occasionally may be clinically suspicious for malignancy.[1]
General
- Rare.
- Like other xanthomas may be associated with abnormal lipid profile.
Presentation:[2]
- Hematuria.
- Irritation.
Gross
Features:[2]
Microscopic
Features:
- Aggregate of foamy histiocytes in the lamina propria.[2]
- No significant nuclear atypia.
DDx:[2]
- Signet ring cell carcinoma.
- Granular cell tumour.
- Malakoplakia.
- Xanthogranulomatous cystitis.
- Mild urothelial atypia (esp. large umbrella cells) in normal urothelium.
IHC
- CD68 +ve.
- S-100 -ve
- Positive in granular cell tumour.
Sign out
Urinary Bladder Lesion, Transurethral Excision: - Xanthoma, see comment. - Negative for carcinoma in situ and negative for invasive malignancy. COMMENT: These lesions may be associated metabolic abnormalities. A lipid profile should be considered.
See also
References
- ↑ Hassouna, H.; Broome, JD.; Swalem, K.; Manikandan, R. (2014). "Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy.". BMJ Case Rep 2014. doi:10.1136/bcr-2014-203836. PMID 24810457.
- ↑ 2.0 2.1 2.2 2.3 Yu, DC.; Patel, P.; Bonert, M.; Carlson, K.; Yilmaz, A.; Paner, G.; Magi-Galluzzi, C.; Lopez-Beltran, A. et al. (Aug 2015). "Urinary bladder xanthoma: a multi-institutional series of 17 cases.". Histopathology 67 (2): 255-61. doi:10.1111/his.12647. PMID 25580863.