Difference between revisions of "In-transit metastasis"
Jump to navigation
Jump to search
| Line 1: | Line 1: | ||
'''In-transit metastasis''' is a type of [[metastasis|metastatic disease]], characterized by tumour nodules | '''In-transit metastasis''' is a type of [[metastasis|metastatic disease]], characterized by tumour nodules arising from the lymphatics<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> between the primary tumour and its local/regional [[lymph node]]s.<ref name=cancergov>URL: [http://www.cancer.gov/dictionary?cdrid=634128 http://www.cancer.gov/dictionary?cdrid=634128]. Accessed on: 28 March 2012.</ref> | ||
It is relatively common in [[malignant melanoma]].<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> It may be seen in a number of tumours, e.g. squamous cell carinoma,<ref name=pmid25775628 >{{Cite journal | last1 = Kocatürk | first1 = E. | last2 = Ülkümen | first2 = PK. | last3 = Kızıltaç | first3 = U. | last4 = Yüksel | first4 = T. | last5 = Kunter | first5 = AS. | last6 = Erhan | first6 = SŞ. | title = In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient. | journal = J Cutan Med Surg | volume = 19 | issue = 2 | pages = 167-70 | month = | year = | doi = 10.2310/7750.2014.14047 | PMID = 25775628 }}</ref><ref>{{Cite journal | last1 = Altunay | first1 = I. | last2 = Çerman | first2 = AA. | last3 = Sakiz | first3 = D. | last4 = Ates | first4 = B. | title = Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review. | journal = Ann Dermatol | volume = 27 | issue = 4 | pages = 442-5 | month = Aug | year = 2015 | doi = 10.5021/ad.2015.27.4.442 | PMID = 26273163 }}</ref> | It is relatively common in [[malignant melanoma]].<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> It may be seen in a number of tumours, e.g. squamous cell carinoma,<ref name=pmid25775628 >{{Cite journal | last1 = Kocatürk | first1 = E. | last2 = Ülkümen | first2 = PK. | last3 = Kızıltaç | first3 = U. | last4 = Yüksel | first4 = T. | last5 = Kunter | first5 = AS. | last6 = Erhan | first6 = SŞ. | title = In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient. | journal = J Cutan Med Surg | volume = 19 | issue = 2 | pages = 167-70 | month = | year = | doi = 10.2310/7750.2014.14047 | PMID = 25775628 }}</ref><ref>{{Cite journal | last1 = Altunay | first1 = I. | last2 = Çerman | first2 = AA. | last3 = Sakiz | first3 = D. | last4 = Ates | first4 = B. | title = Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review. | journal = Ann Dermatol | volume = 27 | issue = 4 | pages = 442-5 | month = Aug | year = 2015 | doi = 10.5021/ad.2015.27.4.442 | PMID = 26273163 }}</ref> | ||
| Line 12: | Line 12: | ||
==Microscopic== | ==Microscopic== | ||
Definition - a separate tumour nodule that is:<ref>URL: [http://www.cancer.gov/dictionary?cdrid=634128 http://www.cancer.gov/dictionary?cdrid=634128]. Accessed on: 28 March 2012.</ref> | Definition - a separate tumour nodule that is:<ref name=cancergov>URL: [http://www.cancer.gov/dictionary?cdrid=634128 http://www.cancer.gov/dictionary?cdrid=634128]. Accessed on: 28 March 2012.</ref> | ||
#>2 cm from the primary tumour. | #>2 cm from the primary tumour. | ||
#Arises between the nearest (regional) [[lymph node]]s and the primary tumour. | #Arises between the nearest (regional) [[lymph node]]s and the primary tumour. | ||
Revision as of 15:25, 11 October 2015
In-transit metastasis is a type of metastatic disease, characterized by tumour nodules arising from the lymphatics[1] between the primary tumour and its local/regional lymph nodes.[2]
It is relatively common in malignant melanoma.[1] It may be seen in a number of tumours, e.g. squamous cell carinoma,[3][4] ecrrine porocarcinoma[5], Merkel cell carcinoma.[6]
General
- May be how a tumour (e.g. melanoma[7]) recurs.
- Poor prognosticator.
Gross
- Often not apparent.
Microscopic
Definition - a separate tumour nodule that is:[2]
- >2 cm from the primary tumour.
- Arises between the nearest (regional) lymph nodes and the primary tumour.
- The tumour presumably arises from a lymphatic that drains the tissue in which the primary tumour grew.
Notes:
- It is called "in-tranist", as it happens while the tumour is on the way to the regional lymph node.
- If a separate tumour nodule <= 2 cm from the primary tumour, it is known as satellitosis.
DDx:
- Satellitosis.
- Lymphovascular invasion - does not form a nodule and does not invade into the surround tissue.
- Lymph node metastasis - should have lymphoid tissue and capsule or be round; definitions dependent on the body site/primary tumour.
- Tumour deposits - also known as discoutinuous extramural extension and peritumoral deposits; concept in colorectal adenocarcinoma.
See also
References
- ↑ 1.0 1.1 Fraker, DL. (Jun 2004). "Management of in-transit melanoma of the extremity with isolated limb perfusion.". Curr Treat Options Oncol 5 (3): 173-84. PMID 15115646.
- ↑ 2.0 2.1 URL: http://www.cancer.gov/dictionary?cdrid=634128. Accessed on: 28 March 2012.
- ↑ Kocatürk, E.; Ülkümen, PK.; Kızıltaç, U.; Yüksel, T.; Kunter, AS.; Erhan, SŞ.. "In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient.". J Cutan Med Surg 19 (2): 167-70. doi:10.2310/7750.2014.14047. PMID 25775628.
- ↑ Altunay, I.; Çerman, AA.; Sakiz, D.; Ates, B. (Aug 2015). "Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review.". Ann Dermatol 27 (4): 442-5. doi:10.5021/ad.2015.27.4.442. PMID 26273163.
- ↑ Imafuku, K.; Hata, H.; Kitamura, S.; Iwata, H.; Shimizu, H. (Jul 2015). "In-transit metastasis of advanced eccrine porocarcinoma.". Int J Dermatol. doi:10.1111/ijd.12928. PMID 26234455.
- ↑ Gunaratne, DA.; Howle, JR.; Veness, MJ. (Mar 2015). "Merkel cell carcinoma: A case of palliative upper limb amputation in a patient with refractory in-transit metastases.". Australas J Dermatol. doi:10.1111/ajd.12291. PMID 25754425.
- ↑ Grotz, TE.; Mansfield, AS.; Kottschade, LA.; Erickson, LA.; Otley, CC.; Markovic, SN.; Jakub, JW. (Dec 2011). "In-transit melanoma: an individualized approach.". Oncology (Williston Park) 25 (14): 1340-8. PMID 22329185.