Difference between revisions of "Graves' disease"
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| Line 7: | Line 7: | ||
*Autoimmune disease leading to hyperthyroidism. | *Autoimmune disease leading to hyperthyroidism. | ||
*Eye problems not resolved with thyroid removal.{{fact}} | *Eye problems not resolved with thyroid removal.{{fact}} | ||
* | *Increased risk of [[papillary thyroid carcinoma]] compared to general population.<ref>{{Cite journal | last1 = Ergin | first1 = AB. | last2 = Saralaya | first2 = S. | last3 = Olansky | first3 = L. | title = Incidental papillary thyroid carcinoma: clinical characteristics and prognostic factors among patients with Graves' disease and euthyroid goiter, Cleveland Clinic experience. | journal = Am J Otolaryngol | volume = 35 | issue = 6 | pages = 784-90 | month = | year = | doi = 10.1016/j.amjoto.2014.04.013 | PMID = 25128909 }}</ref> | ||
Clinical: | Clinical: | ||
Revision as of 21:01, 24 October 2015
Graves' disease, also Graves disease, is an autoimmune disease that leads to hyperthyroidism.
It is often misspelled "Grave's disease".
General
- Clinical diagnosis.
- Autoimmune disease leading to hyperthyroidism.
- Eye problems not resolved with thyroid removal.[citation needed]
- Increased risk of papillary thyroid carcinoma compared to general population.[1]
Clinical:
- TSH-receptor antibody +ve.[2]
Gross
Features:[3]
- Enlarged 50-150 g.
- "Beefy-red" appearance, looks like raw beef.
Microscopic
Features:
- Classic:
- Hypercellular
- Patchy lymphocytes.
- Little colloid.
- Scalloping of colloid; colloid has undulating border.
- Non-specific finding.
- +/-Nuclear clearing.
- +/-Papillae (may mimic papillary thyroid carcinoma in this respect).
Notes:
- Usually has an unimpressive appearance... as it is treated, i.e. history is important.
- Nuclear clearing and papillae are usu. diffuse in Graves' disease - unlike in papillary thyroid carcinoma.
Images
www:
See also
References
- ↑ Ergin, AB.; Saralaya, S.; Olansky, L.. "Incidental papillary thyroid carcinoma: clinical characteristics and prognostic factors among patients with Graves' disease and euthyroid goiter, Cleveland Clinic experience.". Am J Otolaryngol 35 (6): 784-90. doi:10.1016/j.amjoto.2014.04.013. PMID 25128909.
- ↑ Massart, C.; Gibassier, J.; d'Herbomez, M. (Sep 2009). "Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay.". Clin Chim Acta 407 (1-2): 62-6. doi:10.1016/j.cca.2009.06.033. PMID 19576193.
- ↑ Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 30. ISBN 978-0443066856.
- ↑ URL: http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html. Accessed on: 4 December 2011.