Difference between revisions of "Graves' disease"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Graves disease -- low mag.jpg | |||
| Width = | |||
| Caption = Graves' disease. [[H&E stain]]. (WC) | |||
| Synonyms = | |||
| Micro = hypercellular appearance with patchy lymphocytes, little colloid that is scalloped, | |||
+/-nuclear clearing, +/-papillae | |||
| Subtypes = | |||
| LMDDx = [[papillary thyroid carcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = "beefy-red" appearance, enlarged | |||
| Grossing = | |||
| Staging = | |||
| Site = [[thyroid gland]] | |||
| Assdx = [[papillary thyroid carcinoma]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = exophthalmos | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = TSH-receptor antibody - required | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Graves' disease''', also '''Graves disease''', is an autoimmune disease that leads to hyperthyroidism. | '''Graves' disease''', also '''Graves disease''', is an autoimmune disease that leads to hyperthyroidism. | ||
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Clinical: | Clinical: | ||
*TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal | last1 = Massart | first1 = C. | last2 = Gibassier | first2 = J. | last3 = d'Herbomez | first3 = M. | title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. | journal = Clin Chim Acta | volume = 407 | issue = 1-2 | pages = 62-6 | month = Sep | year = 2009 | doi = 10.1016/j.cca.2009.06.033 | PMID = 19576193 }}</ref> | *TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal | last1 = Massart | first1 = C. | last2 = Gibassier | first2 = J. | last3 = d'Herbomez | first3 = M. | title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. | journal = Clin Chim Acta | volume = 407 | issue = 1-2 | pages = 62-6 | month = Sep | year = 2009 | doi = 10.1016/j.cca.2009.06.033 | PMID = 19576193 }}</ref> | ||
*+/-Exophthalmos (bulging eyes). | |||
==Gross== | ==Gross== | ||
Revision as of 02:37, 12 December 2015
| Graves' disease | |
|---|---|
| Diagnosis in short | |
 Graves' disease. H&E stain. (WC) | |
|
| |
| LM |
hypercellular appearance with patchy lymphocytes, little colloid that is scalloped, +/-nuclear clearing, +/-papillae |
| LM DDx | papillary thyroid carcinoma |
| Gross | "beefy-red" appearance, enlarged |
| Site | thyroid gland |
|
| |
| Associated Dx | papillary thyroid carcinoma |
| Signs | exophthalmos |
| Prevalence | uncommon |
| Blood work | TSH-receptor antibody - required |
Graves' disease, also Graves disease, is an autoimmune disease that leads to hyperthyroidism.
It is often misspelled "Grave's disease".
General
- Clinical diagnosis.
- Autoimmune disease leading to hyperthyroidism.
- Eye problems not resolved with thyroid removal.[citation needed]
- Increased risk of papillary thyroid carcinoma compared to general population.[1]
Clinical:
- TSH-receptor antibody +ve.[2]
- +/-Exophthalmos (bulging eyes).
Gross
Features:[3]
- Enlarged 50-150 g.
- "Beefy-red" appearance, looks like raw beef.
Microscopic
Features:
- Classic:
- Hypercellular
- Patchy lymphocytes.
- Little colloid.
- Scalloping of colloid; colloid has undulating border.
- Non-specific finding.
- +/-Nuclear clearing.
- +/-Papillae (may mimic papillary thyroid carcinoma in this respect).
Notes:
- Usually has an unimpressive appearance... as it is treated, i.e. history is important.
- Nuclear clearing and papillae are usu. diffuse in Graves' disease - unlike in papillary thyroid carcinoma.
Images
GD - low mag. (WC)
GD - intermed. mag. (WC)
GD - high mag. (WC)
GD - low mag. (WC)
GD - intermed. mag. (WC)
GD - high mag. (WC)
www:
See also
References
- ↑ Ergin, AB.; Saralaya, S.; Olansky, L.. "Incidental papillary thyroid carcinoma: clinical characteristics and prognostic factors among patients with Graves' disease and euthyroid goiter, Cleveland Clinic experience.". Am J Otolaryngol 35 (6): 784-90. doi:10.1016/j.amjoto.2014.04.013. PMID 25128909.
- ↑ Massart, C.; Gibassier, J.; d'Herbomez, M. (Sep 2009). "Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay.". Clin Chim Acta 407 (1-2): 62-6. doi:10.1016/j.cca.2009.06.033. PMID 19576193.
- ↑ Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 30. ISBN 978-0443066856.
- ↑ URL: http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html. Accessed on: 4 December 2011.