Difference between revisions of "Paired box gene 8"
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*Nonserous epithelial [[ovarian tumours|ovarian neoplasms]] ~ 70%.<ref name=pmid21552115/> | *Nonserous epithelial [[ovarian tumours|ovarian neoplasms]] ~ 70%.<ref name=pmid21552115/> | ||
*[[Endometrial carcinoma]]s ~ 98%.<ref name=pmid21552115/> | *[[Endometrial carcinoma]]s ~ 98%.<ref name=pmid21552115/> | ||
==Negative staining== | |||
[[Image:Lymphoma - lung - PAX8 -- intermed mag.jpg|thumb|right|300px|Negative PAX8 staining in a lymphoma.]] | |||
*[[Urothelial carcinoma]]. | |||
*[[Lymphoma]]. | |||
==See also== | ==See also== | ||
Revision as of 04:50, 3 August 2016
| Paired box gene 8 | |
|---|---|
| Immunostain in short | |
 PAX8 staining in a poorly differentiated carcinoma. | |
| Abbreviation | PAX8 |
| Use | RCC versus other, gynecologic tract malignancy versus other |
| Subspeciality | gynecologic pathology, genitourinary pathology |
| Normal staining pattern | nuclear stain |
| Positive | renal cell carcinomas, renal oncocytoma, thyroid tumours, serous carcinoma, endometrial carcinomas |
Paired box gene 8, commonly known by the abbreviation PAX8, is a commonly used immunostain in gynecologic pathology and genitourinary pathology.
Tumours with positive staining
- Thyroid tumours ~ 90%.[1]
- Renal cell carcinomas ~ 90%.[1]
- Renal oncocytomas ~ 80%.[1]
- High-grade ovarian serous carcinomas ~ 99%.[1]
- Nonserous epithelial ovarian neoplasms ~ 70%.[1]
- Endometrial carcinomas ~ 98%.[1]
