Difference between revisions of "Leiomyoma"
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*Atypical leiomyoma (AKA ''symplastic leiomyoma'') - leiomyoma with nuclear atypia. | *Atypical leiomyoma (AKA ''symplastic leiomyoma'') - leiomyoma with nuclear atypia. | ||
**Image: [http://commons.wikimedia.org/wiki/File:Atypical_leiomyoma_intermed_mag.jpg Atypical leiomyoma (WC)]. | **Image: [http://commons.wikimedia.org/wiki/File:Atypical_leiomyoma_intermed_mag.jpg Atypical leiomyoma (WC)]. | ||
*Benign metastasizing leiomyoma.<ref>{{Cite journal | last1 = Patton | first1 = KT. | last2 = Cheng | first2 = L. | last3 = Papavero | first3 = V. | last4 = Blum | first4 = MG. | last5 = Yeldandi | first5 = AV. | last6 = Adley | first6 = BP. | last7 = Luan | first7 = C. | last8 = Diaz | first8 = LK. | last9 = Hui | first9 = P. | title = Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. | journal = Mod Pathol | volume = 19 | issue = 1 | pages = 130-40 | month = Jan | year = 2006 | doi = 10.1038/modpathol.3800504 | PMID = 16357844 |url=http://www.nature.com/modpathol/journal/v19/n1/full/3800504a.html}}</ref> | |||
**This is just what it sounds like. Some believe these are low grade [[leiomyosarcoma]]s | |||
==IHC== | ==IHC== | ||
Revision as of 04:54, 3 June 2011
Leiomyomas are very common benign smooth muscle tumours. They fit into the soft tissue group of lesions.
General
- Often called "fibroids".
- Extremely common... 40% of women by age 40.
- Benign.
- Can be a cause of AUB (abnormal uterine bleeding).
- Large & multiple associated with infertility.
Gross
- Sharply circumscribed.
- Gray-white.
- Whorled appearance.
Factor that raise concern for leiomyosarcoma:
- Haemorrhage.
- Cystic degeneration.
- Necrosis.
Microscopic
Features:
- Spindle cells arranged in fascicles.
- Fascicular appearance: adjacent groups of cells have their long axis perpendicular to one another; looks somewhat like a braided hair that was cut.
- Whorled arrangement of cells.
Negatives:
- Necrosis (low power) - suggestive of leiomyosarcoma.
- Hypercellularity.
- Nuclear atypia seen at low power.
- Few mitoses.
Variants
- Lipoleiomyoma - with adipose tissue.
- Image: Lipoleiomyoma - low mag. (WC).
- Hypercellular leiomyoma - hypercellularity assoc. with more mutations.[1]
- Atypical leiomyoma (AKA symplastic leiomyoma) - leiomyoma with nuclear atypia.
- Image: Atypical leiomyoma (WC).
- Benign metastasizing leiomyoma.[2]
- This is just what it sounds like. Some believe these are low grade leiomyosarcomas
IHC
Work-up of suspicious leiomyomas:[3]
- CD10 (+ve).
- Ki-67 (-ve).
- SMA (+ve).
- Desmin (+ve).
See also
References
- ↑ http://www3.interscience.wiley.com/journal/119360394/abstract
- ↑ Patton, KT.; Cheng, L.; Papavero, V.; Blum, MG.; Yeldandi, AV.; Adley, BP.; Luan, C.; Diaz, LK. et al. (Jan 2006). "Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis.". Mod Pathol 19 (1): 130-40. doi:10.1038/modpathol.3800504. PMID 16357844. http://www.nature.com/modpathol/journal/v19/n1/full/3800504a.html.
- ↑ STC. 25 February 2009.