Difference between revisions of "Solid pseudopapillary tumour"
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'''Solid pseudopapillary tumour''' is a pancreatic tumour that is usually found in the tail. | |||
It is also known as '''solid pseudopapillary neoplasm''' (abbreviation '''SPN''') and '''solid and papillary epithelial neoplasm''' (abbreviated '''SPEN''').<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html]. Accessed on: 31 October 2011.</ref> | |||
==General== | |||
*Obscure cell of origin. | |||
*Considered low grade, i.e. prognosis is usually good. | |||
===Epidemiology=== | |||
Features:<ref name=Ref_GLP493>{{Ref GLP|493}}</ref> | |||
*Usually females (M:F=1:9). | |||
*Mean age of presentation third decade (20s). | |||
===Management=== | |||
May be followed radiologically. | |||
==Microscopic== | |||
Features:<ref>{{Ref GLP|493-5}}</ref> | |||
*Solid sheets of cells, focally dyscohesive. | |||
*Eosinophilic cytoplasm. | |||
**Occasionally clear cytoplasm.<ref name=pmid18708424>{{cite journal |author=Serra S, Chetty R |title=Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas |journal=J. Clin. Pathol. |volume=61 |issue=11 |pages=1153–9 |year=2008 |month=November |pmid=18708424 |doi=10.1136/jcp.2008.057828 |url=http://jcp.bmj.com/content/61/11/1153}}</ref> | |||
**Focal eosinophilic (intracytoplasmic) globules - '''key feature'''. | |||
*Uniform nuclei with occasional nuclear grooves. | |||
*+/-Necrosis - creating spaces/cavities. | |||
*+/-Cholesterol clefts.<ref name=pmid19156179>{{Cite journal | last1 = Abad Licham | first1 = M. | last2 = Sanchez Lihon | first2 = J. | last3 = Celis Zapata | first3 = J. | title = [Pseudopapillary solid tumor of pancreas in the INEN]. | journal = Rev Gastroenterol Peru | volume = 28 | issue = 4 | pages = 356-61 | month = | year = | doi = | PMID = 19156179 }}</ref> | |||
DDx: | |||
*[[Pancreatic pseudocyst]]. | |||
*Cystadenoma. | |||
*Cystadenocarcinoma. | |||
*[[Pancreatic neuroendocrine tumour]] - may have cytoplasmic vacuolation, [[hyaline globules]].<ref name=pmid18708424/> | |||
===Images=== | |||
<gallery> | |||
Image:Solid_pseudopapillary_tumour_-_very_low_mag.jpg | SPT - very low mag. (WC) | |||
Image:Solid_pseudopapillary_tumour_-_low_mag.jpg | SPT - low mag. (WC) | |||
Image:Solid_pseudopapillary_tumour_-_intermed_mag.jpg | SPT - intermed. mag. (WC) | |||
Image:Solid_pseudopapillary_tumour_-_high_mag.jpg | SPT - high mag. (WC) | |||
Image:Solid_pseudopapillary_tumour_-_very_high_mag.jpg | SPT - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://jcp.bmj.com/content/61/11/1153/F1.large.jpg Solid pseudopapillary tumour (bmj.com)]. | |||
==IHC== | |||
Features:<ref name=pmid18708424>{{cite journal |author=Serra S, Chetty R |title=Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas |journal=J. Clin. Pathol. |volume=61 |issue=11 |pages=1153–9 |year=2008 |month=November |pmid=18708424 |doi=10.1136/jcp.2008.057828 |url=http://jcp.bmj.com/content/61/11/1153}}</ref> | |||
*Beta-catenin +ve ~100% (cytoplasmic & nuclear). | |||
*E-cadherin +ve ~100% (cytoplasmic), -ve (membrane); antibody dependent. | |||
*CD10 +ve ~ 80% (cytoplasmic + dot-like) '''key'''. | |||
*Synaptophysin +ve (weak cytoplasmic) ~70%. | |||
*Progesterone receptor +ve (nuclear) '''key'''. | |||
Others: | |||
*CD56 +ve. | |||
*Chromogranin -ve. | |||
Memory device ''PCB'': '''P'''R (nuclear), '''C'''D10 (cytoplasmic), '''b'''eta-catenin (cytoplasmic & nuclear). | |||
==See also== | |||
*[[Pancreas]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Pancreas]] | |||
Revision as of 10:20, 5 March 2014
Solid pseudopapillary tumour is a pancreatic tumour that is usually found in the tail. It is also known as solid pseudopapillary neoplasm (abbreviation SPN) and solid and papillary epithelial neoplasm (abbreviated SPEN).[1]
General
- Obscure cell of origin.
- Considered low grade, i.e. prognosis is usually good.
Epidemiology
Features:[2]
- Usually females (M:F=1:9).
- Mean age of presentation third decade (20s).
Management
May be followed radiologically.
Microscopic
Features:[3]
- Solid sheets of cells, focally dyscohesive.
- Eosinophilic cytoplasm.
- Occasionally clear cytoplasm.[4]
- Focal eosinophilic (intracytoplasmic) globules - key feature.
- Uniform nuclei with occasional nuclear grooves.
- +/-Necrosis - creating spaces/cavities.
- +/-Cholesterol clefts.[5]
DDx:
- Pancreatic pseudocyst.
- Cystadenoma.
- Cystadenocarcinoma.
- Pancreatic neuroendocrine tumour - may have cytoplasmic vacuolation, hyaline globules.[4]
Images
SPT - very low mag. (WC)
SPT - low mag. (WC)
SPT - intermed. mag. (WC)
SPT - high mag. (WC)
SPT - very high mag. (WC)
www:
IHC
Features:[4]
- Beta-catenin +ve ~100% (cytoplasmic & nuclear).
- E-cadherin +ve ~100% (cytoplasmic), -ve (membrane); antibody dependent.
- CD10 +ve ~ 80% (cytoplasmic + dot-like) key.
- Synaptophysin +ve (weak cytoplasmic) ~70%.
- Progesterone receptor +ve (nuclear) key.
Others:
- CD56 +ve.
- Chromogranin -ve.
Memory device PCB: PR (nuclear), CD10 (cytoplasmic), beta-catenin (cytoplasmic & nuclear).
See also
References
- ↑ URL: http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html. Accessed on: 31 October 2011.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 493. ISBN 978-0443066573.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 493-5. ISBN 978-0443066573.
- ↑ 4.0 4.1 4.2 Serra S, Chetty R (November 2008). "Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas". J. Clin. Pathol. 61 (11): 1153–9. doi:10.1136/jcp.2008.057828. PMID 18708424. http://jcp.bmj.com/content/61/11/1153.
- ↑ Abad Licham, M.; Sanchez Lihon, J.; Celis Zapata, J.. "[Pseudopapillary solid tumor of pancreas in the INEN].". Rev Gastroenterol Peru 28 (4): 356-61. PMID 19156179.