Difference between revisions of "Placental site nodule"
Jump to navigation
Jump to search
(+cat.) |
|||
| Line 1: | Line 1: | ||
'''Placental site nodule''' is a benign remnant of a [[placenta]]. It is seen on [[endometrium|endometrial]] biopsies and hysterectomy specimens. | |||
==General== | |||
*Benign. | |||
*Intermediate trophoblast remnants from a previous gestation.<ref name=pmid19332926>{{Cite journal | last1 = Jacob | first1 = S. | last2 = Mohapatra | first2 = D. | title = Placental site nodule: a tumor-like trophoblastic lesion. | journal = Indian J Pathol Microbiol | volume = 52 | issue = 2 | pages = 240-1 | month = | year = | doi = | PMID = 19332926 | url = http://www.ijpmonline.org/text.asp?2009/52/2/240/48931 }}</ref> | |||
*Usually an incidental finding. | |||
Clinical: | |||
*Usually asymptomatic. | |||
*Vaginal bleeding. (?) | |||
*Infertility. (?) | |||
==Microscopic== | |||
Features:<ref name=pmid19332926/> | |||
*Paucicellular with hyaline material scattered cells. | |||
*Variable cell population: | |||
**Small-large cells. | |||
**Clear to eosinophilic cytoplasm. | |||
**+/-Multinucleation. | |||
Notes: | |||
*No mitotic activity. | |||
DDx: | |||
*Invasive (cervical) [[squamous cell carcinoma]]. | |||
**Can be sorted-out with IHC (SCC will typically be: p16 +ve, MIB1 +ve). | |||
*[[Exaggerated placental site]]. | |||
**Different histomorphology than PSN; EPS:<ref name=pmid19332926/> syncytiotrophoblastic tissue, in cords/nests, no hyaline nodules. | |||
===Images=== | |||
<gallery> | |||
Image:Placental_site_nodule_-_intermed_mag.jpg | PSN - intermed. mag. (WC) | |||
Image:Placental_site_nodule_-_high_mag.jpg | PSN - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2009_52_2_240_48931_u4.jpg PSN (ijpmonline.org)].<ref name=pmid19332926/> | |||
*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=12&cat3=1256&stype=d PSN (gfmer.ch)] - includes images from ''Jacob and Mohapatra''.<ref name=pmid19332926/> | |||
==IHC== | |||
Features:<ref name=pmid19332926/> | |||
*Inhibin alpha +ve. | |||
*CK18 +ve. | |||
*MIB1 low. | |||
Other: | |||
*p16 -ve. | |||
==Sign out== | |||
<pre> | |||
- CONSISTENT WITH MENSTRUAL ENDOMETRIUM (FRAGMENTED ENDOMETRIUM WITH SIMPLE | |||
GLANDS WITH APOPTOTIC CELLS, ABUNDANT NEUTROPHILS, CONDENSED ENDOMETRIAL STROMA | |||
(FOCAL) AND BLOOD). | |||
- PLACENTAL SITE NODULE AND DECIDUA. | |||
- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
<pre> | |||
ENDOMETRIUM, BIOPSY: | |||
- PROLIFERATIVE PHASE ENDOMETRIUM. | |||
- BENIGN PLACENTAL SITE NODULE, SMALL. | |||
- NEGATIVE FOR HYPERPLASIA. | |||
</pre> | |||
==See also== | |||
*[[Gestational trophoblastic disease]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 23:14, 20 March 2014
Placental site nodule is a benign remnant of a placenta. It is seen on endometrial biopsies and hysterectomy specimens.
General
- Benign.
- Intermediate trophoblast remnants from a previous gestation.[1]
- Usually an incidental finding.
Clinical:
- Usually asymptomatic.
- Vaginal bleeding. (?)
- Infertility. (?)
Microscopic
Features:[1]
- Paucicellular with hyaline material scattered cells.
- Variable cell population:
- Small-large cells.
- Clear to eosinophilic cytoplasm.
- +/-Multinucleation.
Notes:
- No mitotic activity.
DDx:
- Invasive (cervical) squamous cell carcinoma.
- Can be sorted-out with IHC (SCC will typically be: p16 +ve, MIB1 +ve).
- Exaggerated placental site.
- Different histomorphology than PSN; EPS:[1] syncytiotrophoblastic tissue, in cords/nests, no hyaline nodules.
Images
PSN - intermed. mag. (WC)
PSN - high mag. (WC)
www:
- PSN (ijpmonline.org).[1]
- PSN (gfmer.ch) - includes images from Jacob and Mohapatra.[1]
IHC
Features:[1]
- Inhibin alpha +ve.
- CK18 +ve.
- MIB1 low.
Other:
- p16 -ve.
Sign out
- CONSISTENT WITH MENSTRUAL ENDOMETRIUM (FRAGMENTED ENDOMETRIUM WITH SIMPLE GLANDS WITH APOPTOTIC CELLS, ABUNDANT NEUTROPHILS, CONDENSED ENDOMETRIAL STROMA (FOCAL) AND BLOOD). - PLACENTAL SITE NODULE AND DECIDUA. - NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.
ENDOMETRIUM, BIOPSY: - PROLIFERATIVE PHASE ENDOMETRIUM. - BENIGN PLACENTAL SITE NODULE, SMALL. - NEGATIVE FOR HYPERPLASIA.
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Jacob, S.; Mohapatra, D.. "Placental site nodule: a tumor-like trophoblastic lesion.". Indian J Pathol Microbiol 52 (2): 240-1. PMID 19332926. http://www.ijpmonline.org/text.asp?2009/52/2/240/48931.