Difference between revisions of "Gonadoblastoma"
Jump to navigation
Jump to search
(+cat.) |
(split out) |
||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Gonadoblastoma_-_b_-_high_mag.jpg | |||
| Width = | |||
| Caption = Gondaloblastoma. [[H&E stain]]. | |||
| Micro = immature germ cells (resembling Sertoli cells or granulosa cells), primitive germ cells resemble those of a [[dysgerminoma]], | |||
+/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells. | |||
| Subtypes = | |||
| LMDDx = [[dysgerminoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[ovary]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Gonadoblastoma''' is a rare [[germ cell tumour]] with sex cord elements. | |||
==General== | |||
*Associated with abnormal sexual development. | |||
*Often coexist with a [[dysgerminoma]]. | |||
*A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements. | |||
==Gross== | |||
*+/-Cystic. | |||
==Microscopic== | |||
Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref> | |||
*Immature germ cells resembling Sertoli cells or granulosa cells. | |||
**Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture. | |||
**Granulosa cells = form follicle-like structures. | |||
***May form nests. | |||
*Primitive germ cells resemble those of a [[dysgerminoma]]. | |||
**Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm. | |||
*+/-Calcification (very common). | |||
*+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Gonadoblastoma_-_intermed_mag.jpg | Gonadoblastoma - intermed. mag. (WC/Nephron) | |||
Image:Gonadoblastoma_-_b_-_high_mag.jpg | Gonadoblastoma - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=40&Case=532 Gonadoblastoma - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?case=532&n=42 Gonadoblastoma - high mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?case=532&n=44 Gonadoblastoma - high mag. (webpathology.com)]. | |||
*[http://www.flickr.com/photos/ckrishnan/3972431774/in/photostream/ Gonadoblastoma - low mag. (flickr.com)]. | |||
*[http://www.flickr.com/photos/ckrishnan/3972432404/in/photostream/ Gonadoblastoma - intermed. mag. (flickr.com)]. | |||
*[http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ Gonadoblastoma - high mag. (flickr.com)]. | |||
*[http://path.upmc.edu/cases/case356.html Gonadoblastoma - several cases (upmc.edu)]. | |||
==See also== | |||
*[[Germ cell tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 23:30, 13 July 2013
| Gonadoblastoma | |
|---|---|
| Diagnosis in short | |
 Gondaloblastoma. H&E stain. | |
|
| |
| LM |
immature germ cells (resembling Sertoli cells or granulosa cells), primitive germ cells resemble those of a dysgerminoma, +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells. |
| LM DDx | dysgerminoma |
| Site | ovary |
|
| |
Gonadoblastoma is a rare germ cell tumour with sex cord elements.
General
- Associated with abnormal sexual development.
- Often coexist with a dysgerminoma.
- A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements.
Gross
- +/-Cystic.
Microscopic
Features:[1]
- Immature germ cells resembling Sertoli cells or granulosa cells.
- Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
- Granulosa cells = form follicle-like structures.
- May form nests.
- Primitive germ cells resemble those of a dysgerminoma.
- Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
- +/-Calcification (very common).
- +/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.[2]
Images
Gonadoblastoma - intermed. mag. (WC/Nephron)
Gonadoblastoma - high mag. (WC/Nephron)
www:
- Gonadoblastoma - low mag. (webpathology.com).
- Gonadoblastoma - high mag. (webpathology.com).
- Gonadoblastoma - high mag. (webpathology.com).
- Gonadoblastoma - low mag. (flickr.com).
- Gonadoblastoma - intermed. mag. (flickr.com).
- Gonadoblastoma - high mag. (flickr.com).
- Gonadoblastoma - several cases (upmc.edu).
See also
References
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1104. ISBN 0-7216-0187-1.
- ↑ URL: http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/. Accessed on: 11 September 2011.