Difference between revisions of "Nucleus-to-cytoplasm ratio"
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*[[Nuclear pleomorphism]]. | *[[Nuclear pleomorphism]]. | ||
*[[Basics]]. | *[[Basics]]. | ||
*[[Cytologic features and malignancy]]. | |||
==References== | ==References== | ||
Revision as of 23:39, 27 December 2011
Nucleus-to-cytoplasm ratio, also nuclear-cytoplasmic ratio, is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated NC ratio.
High NC ratio is strong predictor of malignancy.[1] Like very rule, there are exceptions.
High NC ratio in normal cells
- Lymphocytes.
Low NC ratio in cancer
- Fibrolamellar hepatocellular carcinoma.
- Acinic cell carcinoma.
- Many others.
High NC ratio in cancer
The classic malignant high NC ratio cell is small cell carcinoma, which is in the small round cell tumour group.
- Many other tumours.
See also
References
- ↑ Mehrotra, R.; Gupta, A.; Singh, M.; Ibrahim, R. (2006). "Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions.". Mol Cancer 5: 11. doi:10.1186/1476-4598-5-11. PMID 16556320.