Difference between revisions of "Hypersensitivity"
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| '''Antibody mediated h.''' | | '''Antibody mediated h.''' | ||
| Cytotoxic antibody dependent h. | | Cytotoxic antibody dependent h. | ||
| [[Goodpasture syndrome]], [[Graves disease]] | | [[Goodpasture syndrome]],<ref name=pmid384140>{{Cite journal | last1 = Briggs | first1 = WA. | last2 = Johnson | first2 = JP. | last3 = Teichman | first3 = S. | last4 = Yeager | first4 = HC. | last5 = Wilson | first5 = CB. | title = Antiglomerular basement membrane antibody-mediated glomerulonephritis and Goodpasture's syndrome. | journal = Medicine (Baltimore) | volume = 58 | issue = 5 | pages = 348-61 | month = Sep | year = 1979 | doi = | PMID = 384140 }}</ref> [[Graves disease]] | ||
| antibodies (IgG, IgM) | | antibodies (IgG, IgM) | ||
| (antibody-mediated) phagocytosis & lysis | | (antibody-mediated) phagocytosis & lysis | ||
Latest revision as of 14:14, 30 April 2012
Hypersensitivity is an inappropriate immune system response. It is a thingy one may get quizzed on.
Gell & Coombs classification
Gell & Coombs, in the 1960s, came-up with a classification that has endured.
| Type (I-IV) | Formal name[1] | Name | Example | Mediator | Pathology |
|---|---|---|---|---|---|
| I | Immediate h. | Allergic h. | anaphylaxis, (atopic) bronchial asthma, allergies | antibodies (IgE) | mast cells, inflammation (esp. eosinophils), edema |
| II | Antibody mediated h. | Cytotoxic antibody dependent h. | Goodpasture syndrome,[2] Graves disease | antibodies (IgG, IgM) | (antibody-mediated) phagocytosis & lysis |
| III | Immune complex mediated h. | Immune complex mediated h. | systemic lupus erythematosus, hypersensitivity pneumonitis,[3] rheumatoid arthritis | antigen-antibody complex | inflammation, vasculitis with fibrinoid necrosis |
| IV | Cell-mediated h. | Delayed-type hypersensitivity | tuberculosis, contact dermatitis, chronic transplant rejection, inflammatory bowel disease | activated T cells | perivascular inflammation, granulomas |
Memory device ACID:[4]
- Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
- ↑ Briggs, WA.; Johnson, JP.; Teichman, S.; Yeager, HC.; Wilson, CB. (Sep 1979). "Antiglomerular basement membrane antibody-mediated glomerulonephritis and Goodpasture's syndrome.". Medicine (Baltimore) 58 (5): 348-61. PMID 384140.
- ↑ Kaltreider, HB. (Nov 1993). "Hypersensitivity pneumonitis.". West J Med 159 (5): 570-8. PMID 8279154. http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8279154/?tool=pubmed.
- ↑ URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.