Difference between revisions of "Arias-Stella reaction"
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*[[Choriocarcinoma]]. | *[[Choriocarcinoma]]. | ||
*[[Herpes simplex virus|Herpetic]] [[endometritis]]. | *[[Herpes simplex virus|Herpetic]] [[endometritis]]. | ||
*[[ | *[[Clear cell endometrial carcinoma]]. | ||
*[[Serous endometrial carcinoma]].<ref name=pmid20173505>{{Cite journal | last1 = Félix | first1 = A. | last2 = Nogales | first2 = FF. | last3 = Arias-Stella | first3 = J. | title = Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens. | journal = Int J Gynecol Pathol | volume = 29 | issue = 2 | pages = 185-8 | month = Mar | year = 2010 | doi = 10.1097/PGP.0b013e3181b7015e | PMID = 20173505 }}</ref> | |||
Images: | Images: | ||
Revision as of 04:27, 26 June 2012
The Arias-Stella reaction is a benign change.
General
- Benign atypical endometrial changes associated with chorionic tissue.[1]
- May be seen in a normal pregnancy, hydatidiform moles, others.
- Historically it was diagnosed as endometrial cancer.
Note:
- To the novice... the nuclei look really scary, i.e. they look like cancer.
Microscopic
Features:[1]
- Epithelial component of endometrium with large nuclei - key feature.
- +/-Nuclear hyperchromasia, i.e. dark nuclei.
- +/-Irregular nuclear membrane.
- +/-Nuclear clearing.[2]
- +/-Nuclear pseudoinclusions.
- NC ratio is preserved.[2]
- Usually a focal change.
- +/-Mitoses - uncommon.
Notes:
- No decidual reaction in the stroma.
DDx:
- Choriocarcinoma.
- Herpetic endometritis.
- Clear cell endometrial carcinoma.
- Serous endometrial carcinoma.[3]
Images:
Subtypes
There are five subtypes:[1]
- Minimal atypia.
- Usually early gestation.
- Early secretory pattern.
- Mimics secretory endometrium: cytoplasmic vacuoles, central nucleus, palisading architecture.
- Secretory or hypersecretory pattern.
- Regenerative, proliferative or nonsecretory pattern.
- Monstrous cell pattern.
See also
References
- ↑ 1.0 1.1 1.2 Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after.". Adv Anat Pathol 9 (1): 12-23. PMID 11756756.
- ↑ 2.0 2.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 236-7. ISBN 978-0470519035.
. Cite error: Invalid
<ref>tag; name "Ref_DCHH236-7" defined multiple times with different content - ↑ Félix, A.; Nogales, FF.; Arias-Stella, J. (Mar 2010). "Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens.". Int J Gynecol Pathol 29 (2): 185-8. doi:10.1097/PGP.0b013e3181b7015e. PMID 20173505.