Difference between revisions of "Nephrogenic adenoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Nephrogenic_adenoma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Nephrogenic adenoma. [[H&E stain]]. | |||
| Micro = tubular structures with a microcystic appearance lined by hobnailed cells +/-thick eosinophilic basement membrane, usually associated with chronic inflammation. | |||
| Subtypes = | |||
| LMDDx = [[urothelial carcinoma]] microcystic and nested variants, [[prostatic adenocarcinoma]], | |||
[[clear cell adenocarcinoma]] | |||
| Stains = | |||
| IHC = CK7 +ve, PAX8 +ve, p53 -ve, CEA -ve, Ki-67 low (<5%) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[urothelium]] - usu. [[urinary bladder]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Nephrogenic adenoma''', also known as '''mesonephric adenoma''',<ref name=pmid21716880>{{Cite journal | last1 = Singh | first1 = KJ. | title = Mesonephric adenoma in remnant ureteric stump: A rare entity. | journal = Indian J Urol | volume = 27 | issue = 1 | pages = 140-1 | month = Jan | year = 2011 | doi = 10.4103/0970-1591.78414 | PMID = 21716880 }}</ref> and '''nephrogenic metaplasia''', is a rare lesion that is classically in the [[urinary bladder]] and can mimic [[adenocarcinoma]]. | '''Nephrogenic adenoma''', also known as '''mesonephric adenoma''',<ref name=pmid21716880>{{Cite journal | last1 = Singh | first1 = KJ. | title = Mesonephric adenoma in remnant ureteric stump: A rare entity. | journal = Indian J Urol | volume = 27 | issue = 1 | pages = 140-1 | month = Jan | year = 2011 | doi = 10.4103/0970-1591.78414 | PMID = 21716880 }}</ref> and '''nephrogenic metaplasia''', is a rare lesion that is classically in the [[urinary bladder]] and can mimic [[adenocarcinoma]]. | ||
Revision as of 20:35, 7 November 2013
| Nephrogenic adenoma | |
|---|---|
| Diagnosis in short | |
 Nephrogenic adenoma. H&E stain. | |
|
| |
| LM | tubular structures with a microcystic appearance lined by hobnailed cells +/-thick eosinophilic basement membrane, usually associated with chronic inflammation. |
| LM DDx |
urothelial carcinoma microcystic and nested variants, prostatic adenocarcinoma, clear cell adenocarcinoma |
| IHC | CK7 +ve, PAX8 +ve, p53 -ve, CEA -ve, Ki-67 low (<5%) |
| Site | urothelium - usu. urinary bladder |
|
| |
| Prevalence | uncommon |
| Prognosis | benign |
Nephrogenic adenoma, also known as mesonephric adenoma,[1] and nephrogenic metaplasia, is a rare lesion that is classically in the urinary bladder and can mimic adenocarcinoma.
General
Features:[2]
- Benign.
- May mimic adenocarcinoma!
- Classic location is the urinary bladder.
- Also reported in ureter and prostatic urethra.
- It is thought to result from displacement of renal tubular cells, as this entity in renal transplant recipients is graft derived.[3]
Microscopic
Features:[2]
- Tubular structures - key feature.
- Hobnailed cells.
- +/-Thick eosinophilic basement membrane.
- Microcystic appearance.
- Usually associated with chronic inflammation.
Notes:
- May mimic vascular/lymphatic channels - can be sorted-out with IHC.
DDx:
- Urothelial carcinoma, microcystic and nested variants.
- Prostatic adenocarcinoma.
- Clear cell adenocarcinoma.
Images
Nephrogenic adenoma - low mag. (WC/Nephron)
Nephrogenic adenoma - intermed. mag. (WC/Nephron)
Nephrogenic adenoma - high mag. (WC/Nephron)
Nephrogenic adenoma - very high mag. (WC/Nephron)
www:
IHC
Features:[5]
- CK7 +ve.
- PAX2 +ve.
- PAX8 +ve.
- AMACR +ve/-ve.
Others:[2]
- p53 -ve.
- CEA -ve.
- Ki-67 low (<5%).
See also
References
- ↑ Singh, KJ. (Jan 2011). "Mesonephric adenoma in remnant ureteric stump: A rare entity.". Indian J Urol 27 (1): 140-1. doi:10.4103/0970-1591.78414. PMID 21716880.
- ↑ 2.0 2.1 2.2 Gokaslan, ST.; Krueger, JE.; Albores-Saavedra, J. (Jul 2002). "Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases.". Mod Pathol 15 (7): 765-70. doi:10.1097/01.MP.0000019578.51568.24. PMID 12118115. http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html. Cite error: Invalid
<ref>tag; name "pmid12118115" defined multiple times with different content - ↑ Mazal, PR.; Schaufler, R.; Altenhuber-Müller, R.; Haitel, A.; Watschinger, B.; Kratzik, C.; Krupitza, G.; Regele, H. et al. (Aug 2002). "Derivation of nephrogenic adenomas from renal tubular cells in kidney-transplant recipients.". N Engl J Med 347 (9): 653-9. doi:10.1056/NEJMoa013413. PMID 12200552.
- ↑ Kunju, LP. (Oct 2010). "Nephrogenic adenoma: report of a case and review of morphologic mimics.". Arch Pathol Lab Med 134 (10): 1455-9. doi:10.1043/2010-0226-CR.1. PMID 20923300.
- ↑ Alexiev, BA.; Levea, CM. (Mar 2012). "Nephrogenic Adenoma of the Urinary Tract: A Review.". Int J Surg Pathol. doi:10.1177/1066896912439095. PMID 22415059.