Difference between revisions of "NUT carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = NUT_midline_carcinoma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = NUT midline carcinoma. [[H&E stain]]. | |||
| Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium | |||
| Subtypes = | |||
| LMDDx = [[Carcinoma ex pleomorphic adenoma]], poorly differentiated carcinoma | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = t(15;19) | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[head and neck pathology|head and neck]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''NUT midline carcinoma''', abbreviated '''NMC''', is a super rare tumour of the [[head and neck pathology|head and neck]]. The WHO calls this tumour '''carcinoma with t(15;19) translocation'''.<ref name=Ref_WMSP145>{{Ref WMSP|145}}</ref> | '''NUT midline carcinoma''', abbreviated '''NMC''', is a super rare tumour of the [[head and neck pathology|head and neck]]. The WHO calls this tumour '''carcinoma with t(15;19) translocation'''.<ref name=Ref_WMSP145>{{Ref WMSP|145}}</ref> | ||
Revision as of 20:53, 26 November 2013
| NUT carcinoma | |
|---|---|
| Diagnosis in short | |
 NUT midline carcinoma. H&E stain. | |
|
| |
| LM | cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium |
| LM DDx | Carcinoma ex pleomorphic adenoma, poorly differentiated carcinoma |
| Molecular | t(15;19) |
| Site | head and neck |
|
| |
| Prevalence | very rare |
NUT midline carcinoma, abbreviated NMC, is a super rare tumour of the head and neck. The WHO calls this tumour carcinoma with t(15;19) translocation.[1]
General
- Not specific to any tissue type or organ.[2]
- Defined by mutation in NUT gene on chromosome 15.
- NUT = Nuclear protein in testis.[3]
Clinical:
- Usually midline - as the name of the tumour suggests.
- Case report of a NMC in the parotid gland.[4]
- Head, neck and mediastinum.[5]
- Very poor prognosis.[4]
Microscopic
- Poorly differentiated carcinoma.
- Cohesive malignant cells.
- Islands of well-differentiated squamous epithelium - key feature.
DDx:
- Carcinoma ex pleomorphic adenoma.
- Poorly differentiated carcinoma.
Images:
Molecular
- Rearrangement of the NUT gene.[2]
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 145. ISBN 978-0781765275.
- ↑ 2.0 2.1 2.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ↑ 4.0 4.1 den Bakker, MA.; Beverloo, BH.; van den Heuvel-Eibrink, MM.; Meeuwis, CA.; Tan, LM.; Johnson, LA.; French, CA.; van Leenders, GJ. (Aug 2009). "NUT midline carcinoma of the parotid gland with mesenchymal differentiation.". Am J Surg Pathol 33 (8): 1253-8. doi:10.1097/PAS.0b013e3181abe120. PMID 19561446.
- ↑ 5.0 5.1 5.2 French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608749