Difference between revisions of "Papillary urothelial hyperplasia"
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*[[Low-grade papillary urothelial carcinoma]] - have well-developed fibrovascular core. | *[[Low-grade papillary urothelial carcinoma]] - have well-developed fibrovascular core. | ||
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*[[PUNLMP]]. | *[[PUNLMP]]. | ||
*[[Urothelial papilloma]] - well-developed fibrovascular cores, uniform urothelial thickness. | *[[Urothelial papilloma]] - well-developed fibrovascular cores, uniform urothelial thickness. | ||
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===Image=== | ===Image=== | ||
*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)]. | *[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)]. | ||
Revision as of 19:37, 27 January 2014
Papillary urothelial hyperplasia, abbreviated PUH, is a benign lesion of the urothelium that is associated with the subsequent development of low-grade papillary urothelial carcinoma.
General
- Benign.
- Strong association with papillary neoplasms.
- On follow-up (in one study) >1/4, without prior history of urothelial neoplasia, have urothelial carcinoma; thus, follow-up is recommended.[1]
Microscopic
Features:[2]
- Inflammation.
- Rare papillary structures.
- Do not have a well-developed fibrovascular core.
- Tent-like appearance - short/stubby.
- No urothelial cell atypia.
DDx:
- Low-grade papillary urothelial carcinoma - have well-developed fibrovascular core.
Image
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URINARY BLADDER, BIOPSY: - REACTIVE PAPILLARY HYPERPLASIA, SEE COMMENT. - NO MUSCULARIS PROPRIA IDENTIFIED. - CYSTITIS CYSTICA ET GLANDULARIS. - NO EVIDENCE OF MALIGNANCY. COMMENT: The urothelial forms rare papillary structures; these are interpreted as reactive. The urothelium stains as follow: CK7: positive, patchy (normal). CK20: only rare superficial cells (normal). Ki-67: rare, focally increased, negative in papillary structures (<10%). p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). Follow-up is recommended.
See also
References
- ↑ Readal, N.; Epstein, JI. (Jun 2010). "Papillary urothelial hyperplasia: relationship to urothelial neoplasms.". Pathology 42 (4): 360-3. doi:10.3109/00313021003767322. PMID 20438409.
- ↑ URL: http://pathology.jhu.edu/bladder/definitions.cfm. Accessed on: 27 January 2014.