Difference between revisions of "Papillary urothelial hyperplasia"
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Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | ||
*Inflammation. | *Inflammation. | ||
* | *Papillary structures without well-developed fibrovascular cores. | ||
**Tent-like appearance ''or'' spike-like appearance - short/stubby papillae not longer than the urothelium is thick.<ref>URL: [http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/ http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/]. Accessed on: 27 January 2014.</ref> | |||
**Tent-like appearance - short/stubby. | |||
*No urothelial cell atypia. | *No urothelial cell atypia. | ||
Latest revision as of 19:56, 27 January 2014
Papillary urothelial hyperplasia, abbreviated PUH, is a benign lesion of the urothelium that is associated with the subsequent development of low-grade papillary urothelial carcinoma.
General
- Benign.
- Strong association with papillary neoplasms.
- On follow-up (in one study) >1/4, without prior history of urothelial neoplasia, have urothelial carcinoma; thus, follow-up is recommended.[1]
Microscopic
Features:[2]
- Inflammation.
- Papillary structures without well-developed fibrovascular cores.
- Tent-like appearance or spike-like appearance - short/stubby papillae not longer than the urothelium is thick.[3]
- No urothelial cell atypia.
DDx:
- Low-grade papillary urothelial carcinoma - have well-developed fibrovascular core.
Image
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URINARY BLADDER, BIOPSY: - REACTIVE PAPILLARY HYPERPLASIA, SEE COMMENT. - NO MUSCULARIS PROPRIA IDENTIFIED. - CYSTITIS CYSTICA ET GLANDULARIS. - NO EVIDENCE OF MALIGNANCY. COMMENT: The urothelial forms rare papillary structures; these are interpreted as reactive. The urothelium stains as follow: CK7: positive, patchy (normal). CK20: only rare superficial cells (normal). Ki-67: rare, focally increased, negative in papillary structures (<10%). p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). Follow-up is recommended.
See also
References
- ↑ Readal, N.; Epstein, JI. (Jun 2010). "Papillary urothelial hyperplasia: relationship to urothelial neoplasms.". Pathology 42 (4): 360-3. doi:10.3109/00313021003767322. PMID 20438409.
- ↑ URL: http://pathology.jhu.edu/bladder/definitions.cfm. Accessed on: 27 January 2014.
- ↑ URL: http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/. Accessed on: 27 January 2014.