Difference between revisions of "Invasive ductal carcinoma of the breast"

Revision as of 10:17, 14 February 2014

Invasive ductal carcinoma of the breast is the most common form of invasive breast cancer. It arises from ductal carcinoma in situ.

It is also known as NST (No Specific Type). Generically, it may be referred to as invasive mammary carcinoma.

Features:

Atypical cells:
- Usually >2x RBC diameter.
- Nucleoli common.
- Forming ducts or sheets.
- +/-Mitoses.
- +/-Necrosis.
Evidence of invasion:
- Atypical nucleus adjacent to adipocyte - diagnostic.
- "Infiltrative" pattern:
  - Small glands of variable size within desmoplastic stroma.
  - Glands lined by a single layer of cells.

DDx:

Myoepithelial markers - diagnostic for invasion:

Prognostic markers - may be useful for metastates:

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-#redirect [[Invasive_breast_cancer#Invasive_ductal_carcinoma_of_the_breast]]
+'''Invasive ductal carcinoma of the breast''' is the most common form of [[invasive breast cancer]]. It arises from [[ductal carcinoma in situ]].
+It is also known as '''NST''' (No Specific Type). Generically, it may be referred to as ''invasive mammary carcinoma''.
+==General==
+*Most common type of [[invasive breast cancer]].
+==Microscopic==
+Features:
+*Atypical cells:
+**Usually >2x [[RBC]] diameter.
+**Nucleoli common.
+**Forming ducts ''or'' sheets.
+**+/-Mitoses.
+**+/-Necrosis.
+*Evidence of invasion:
+**Atypical nucleus adjacent to adipocyte - '''diagnostic'''.
+**"Infiltrative" pattern:
+***Small glands of variable size within desmoplastic stroma.
+***Glands lined by a single layer of cells.
+DDx:
+*[[DCIS]].
+*[[Invasive lobular carcinoma]].
+==IHC==
+Myoepithelial markers - '''diagnostic''' for invasion:
+*SMMS -ve.
+*p63 -ve.
+Prognostic markers - may be useful for metastates:
+*ER +ve (diffuse).
+*PR +ve (diffuse).
+*HER2 -ve.
+==See also==
+*[[Invasive breast cancer]].
+*[[DCIS]].
+==References==
+{{Reflist|2}}
+[[Category:Invasive breast cancer]]
 [[Category:Diagnosis]]