Difference between revisions of "Pityriasis rubra pilaris"
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==Stains== | ==Stains== | ||
*[[PASD stain|PASD]] -ve for fungal organisms.<ref name=pmid23286804/> | *[[PASD stain|PASD]] -ve for fungal organisms.<ref name=pmid23286804/> | ||
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==IHC== | ==IHC== | ||
==Molecular== | ==Molecular== | ||
==Sign out== | ==Sign out== --> | ||
==See also== | ==See also== | ||
*[[Inflammatory skin disorders]]. | *[[Inflammatory skin disorders]]. | ||
Revision as of 06:47, 24 September 2014
| Pityriasis rubra pilaris | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | alterating orthokeratosis and parakeratosis (known as "checkerboard pattern"), +/-eosinophils (common), follicular plugging, acantholysis (common) |
| LM DDx | fungal infection |
| Stains | PASD -ve (to r/o fungal infections) |
| Gross | salmon-coloured plaques, well-demarcated |
| Site | skin - see inflammatory skin disorders |
|
| |
| Prevalence | uncommon |
| Treatment | retinoids, methotrexate and others |
Pityriasis rubra pilaris, abbreviated PRP, is an uncommon inflammatory skin disorder.
General
- Uncommon.[1]
- Typically sporadic, may be familial.[2]
- Bimodal age distribution:[3]
- Children: <10 years.
- Adults: 40s and 50s.
Treatment:
- Retinoids, methotrexate and others.[3]
Gross
Microscopic
Features:[1]
- Alterating orthokeratosis and parakeratosis - known as "checkerboard pattern".
- +/-Eosinophils (common).
- Follicular plugging.
- Acantholysis.[4]
DDx:
- Fungal infection.
- Psoriasis vulgaris.[5]
Images
Stains
See also
References
- ↑ 1.0 1.1 Marrouche, N.; Kurban, M.; Kibbi, AG.; Abbas, O. (Apr 2014). "Pityriasis rubra pilaris: clinicopathological study of 32 cases from Lebanon.". Int J Dermatol 53 (4): 434-9. PMID 24783259.
- ↑ Mercer, JM.; Pushpanthan, C.; Anandakrishnan, C.; Landells, ID.. "Familial pityriasis rubra pilaris: case report and review.". J Cutan Med Surg 17 (4): 226-32. PMID 23815954.
- ↑ 3.0 3.1 3.2 Klein, A.; Landthaler, M.; Karrer, S. (2010). "Pityriasis rubra pilaris: a review of diagnosis and treatment.". Am J Clin Dermatol 11 (3): 157-70. doi:10.2165/11530070-000000000-00000. PMID 20184391.
- ↑ 4.0 4.1 4.2 Leger, M.; Newlove, T.; Robinson, M.; Patel, R.; Meehan, S.; Ramachandran, S. (Dec 2012). "Pityriasis rubra pilaris.". Dermatol Online J 18 (12): 14. PMID 23286804.
- ↑ Brinster, NK. (Mar 2008). "Dermatopathology for the surgical pathologist: a pattern based approach to the diagnosis of inflammatory skin disorders (part I).". Adv Anat Pathol 15 (2): 76-96. doi:10.1097/PAP.0b013e3181664e8d. PMID 18418089.