Difference between revisions of "Acquired cystic disease-associated renal cell carcinoma"
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'''Acquired cystic disease-associated renal cell carcinoma''', abbreviated ''ACD-RCC'', is a rare kidney cancer that arises in the context of chronic renal failure. | '''Acquired cystic disease-associated renal cell carcinoma''', abbreviated '''ACD-RCC''', is a rare [[kidney cancer]] that arises in the context of [[chronic renal failure]]. | ||
==General== | ==General== | ||
| Line 9: | Line 9: | ||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Tubular strucutres with cribriforming. | *Tubular strucutres with cribriforming/a sieve-like architecture.<ref>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }} | ||
</ref> | |||
**Hobnail cells. | **Hobnail cells. | ||
*Oxylate crystals - '''important'''. | *Oxylate crystals - '''important'''. | ||
Revision as of 20:48, 3 October 2014
Acquired cystic disease-associated renal cell carcinoma, abbreviated ACD-RCC, is a rare kidney cancer that arises in the context of chronic renal failure.
General
- Arise in the context of long-standing end-stage renal disease (ESRD).[1]
Gross
- Cysts.
Microscopic
Features:
- Tubular strucutres with cribriforming/a sieve-like architecture.[2]
- Hobnail cells.
- Oxylate crystals - important.
- Look somewhat like cholesterol clefts.
DDx:
IHC
Features:[1]
- AMACR +ve.
- CD10 +ve.
- Pankeratin +ve.
- CK7 +ve (heterogeneous).
Others:[1]
- CD68 -ve.
- PAX2 -ve.
See also
References
- ↑ 1.0 1.1 1.2 Ahn, S.; Kwon, GY.; Cho, YM.; Jun, SY.; Choi, C.; Kim, HJ.; Park, YW.; Park, WS. et al. (Mar 2013). "Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features.". Med Mol Morphol. doi:10.1007/s00795-013-0028-x. PMID 23471757.
- ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.