Difference between revisions of "Eccrine spiradenoma"
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==General== | ==General== | ||
*A [[painful skin lesion]]. | *One of the 'ANGEL' tumors | ||
**A [[painful skin lesion]]. | |||
**Many of these are vascular | |||
**Think of blood vessels throbbing. | |||
*Benign. | *Benign. | ||
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**Myoepithelial. | **Myoepithelial. | ||
*+/-Lymphocytes. | *+/-Lymphocytes. | ||
*Vascular component - large and small blood vessels. | |||
DDx: | DDx: | ||
*[[Dermal cylindroma]]. | *[[Dermal cylindroma]]- | ||
**These two tumors are very closely related | |||
**Many tumors have areas of both spiradenoma and cylindroma. | |||
*[[Trichoepithelioma]]. | *[[Trichoepithelioma]]. | ||
*[[Glomus tumor]] - | |||
**The location usually excludes glomus tumor. | |||
===Images=== | ===Images=== | ||
Revision as of 05:32, 10 February 2015
| Eccrine spiradenoma | |
|---|---|
| Diagnosis in short | |
 Eccrine spiradenoma. H&E stain. | |
|
| |
| Synonyms | spiradenoma |
|
| |
| LM | dense nests of cells in the dermis ("dermal blue balls"), mixed cell population (epithelial, myoepithelial, +/-lymphocytes) |
| LM DDx | dermal cylindroma, trichoepithelioma |
| IHC | S100 +ve, CK7 +ve, CK18 +ve |
| Site | skin |
|
| |
| Symptoms | pain - see painful skin lesions |
| Prevalence | uncommon |
| Prognosis | benign |
| Other | may be related to dermal cylindroma |
| Clin. DDx | painful skin lesions, others |
| Treatment | excision |
Eccrine spiradenoma, also spiradenoma,[1] is (usually) a benign, painful skin thingy. There is case series of malignant ones.[2]
General
- One of the 'ANGEL' tumors
- A painful skin lesion.
- Many of these are vascular
- Think of blood vessels throbbing.
- Benign.
Microscopic
- Dense nests of cells in the dermis; "dermal blue balls".
- Mixed cell population:
- Epithelial.
- Myoepithelial.
- +/-Lymphocytes.
- Vascular component - large and small blood vessels.
DDx:
- Dermal cylindroma-
- These two tumors are very closely related
- Many tumors have areas of both spiradenoma and cylindroma.
- Trichoepithelioma.
- Glomus tumor -
- The location usually excludes glomus tumor.
Images
Eccrine spiradenoma - very low mag. (WC)
Eccrine spiradenoma - low mag. (WC)
Eccrine spiradenoma - intermed. mag. (WC)
Eccrine spiradenoma - high mag. (WC)
Eccrine spiradenoma - very high mag. (WC)
www:
IHC
Features:[5]
- S100 +ve.
- Keratins 7, 8, and 18 +ve.
Notes:
- IHC profile essentially identical to dermal cylindroma.[5]
See also
References
- ↑ URL: http://emedicine.medscape.com/article/1062079-overview. Accessed on: 9 May 2011.
- ↑ Andreoli, MT.; Itani, KM. (May 2011). "Malignant eccrine spiradenoma: a meta-analysis of reported cases.". Am J Surg 201 (5): 688-92. doi:10.1016/j.amjsurg.2010.04.015. PMID 20851376.
- ↑ 3.0 3.1 URL: http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448. Accessed on: 29 November 2010.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970191-7. Accessed on: 10 May 2011.
- ↑ 5.0 5.1 Meybehm, M.; Fischer, HP. (Apr 1997). "Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations.". Am J Dermatopathol 19 (2): 154-61. PMID 9129700.