Difference between revisions of "ELOC-mutated renal cell carcinoma"
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*Clear cells with abundant cytoplasm. | *Clear cells with abundant cytoplasm. | ||
*Usually [[ISUP nucleolar grade]] 2. | *Usually [[ISUP nucleolar grade]] 2. | ||
*Fibromuscular bands - '''key feature'''. | |||
DDx: | DDx: | ||
*[[Clear cell renal cell carcinoma]]. | *[[Clear cell renal cell carcinoma]]. | ||
*[[Clear cell tubulopapillary renal cell carcinoma]]. | *[[Clear cell tubulopapillary renal cell carcinoma]]. | ||
*[[Tuberous sclerosis-associated renal cell carcinoma]]. | |||
==See also== | ==See also== | ||
Revision as of 22:19, 11 June 2015
TCEB1-mutated renal cell carcinoma, also renal cell carcinoma with TCEB1 mutation, is an evolving entity that is similar to clear cell renal cell carcinoma and clear cell tubulopapillary renal cell carcinoma.[1]
It should not be confused with TFEB renal cell carcinoma, also known as renal tumour with t(6;11) translocation.
General
- Evolving entity.
Gross
- Cystic changes.
Microscopic
Features:
- Clear cells with abundant cytoplasm.
- Usually ISUP nucleolar grade 2.
- Fibromuscular bands - key feature.
DDx:
- Clear cell renal cell carcinoma.
- Clear cell tubulopapillary renal cell carcinoma.
- Tuberous sclerosis-associated renal cell carcinoma.
See also
References
- ↑ Hakimi, AA.; Tickoo, SK.; Jacobsen, A.; Sarungbam, J.; Sfakianos, JP.; Sato, Y.; Morikawa, T.; Kume, H. et al. (Jun 2015). "TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype.". Mod Pathol 28 (6): 845-53. doi:10.1038/modpathol.2015.6. PMID 25676555.