Difference between revisions of "ELOC-mutated renal cell carcinoma"

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*[[Clear cell tubulopapillary renal cell carcinoma]] - have luminal nuclei.
*[[Clear cell tubulopapillary renal cell carcinoma]] - have luminal nuclei.
*[[Tuberous sclerosis-associated renal cell carcinoma]].
*[[Tuberous sclerosis-associated renal cell carcinoma]].
===Images===
====Morphology compatible====
<gallery>
Image: Renal cell carcinoma with clear cells and fibromuscular bands -- very low mag.jpg | RCC CCFB - very low mag.
Image: Renal cell carcinoma with clear cells and fibromuscular bands -- low mag.jpg | RCC CCFB - low mag.
Image: Renal cell carcinoma with clear cells and fibromuscular bands -- intermed mag.jpg | RCC CCFB - intermed. mag.
Image: Renal cell carcinoma with clear cells and fibromuscular bands -- high mag.jpg | RCC CCFB - high mag.
Image: Renal cell carcinoma with clear cells and fibromuscular bands - alt -- high mag.jpg | RCC CCFB - high mag.
Image: Renal cell carcinoma with clear cells and fibromuscular bands -- very high mag.jpg | RCC CCFB - very high mag.
</gallery>


==IHC==
==IHC==

Revision as of 21:55, 12 June 2015

ELOC-mutated renal cell carcinoma
Diagnosis in short

RCC with clear cells and fibromuscular band - morphology compatible with TCEB1 mutation. H&E stain. (WC)
LM clear cells with abundant cytoplasm and basal nuclei (may have luminal nuclei), usually ISUP nucleolar grade 2, fibromuscular bands
LM DDx clear cell renal cell carcinoma, clear cell tubulopapillary renal cell carcinoma
IHC CK7 +ve, CD10 +ve, CK34betaE12 -ve
Molecular TCEB1 mutation
Site kidney - see kidney tumours
Syndromes possibly tuberous sclerosis - see tuberous sclerosis-associated renal cell carcinoma
Prevalence very rare - evolving entity
Prognosis good - based on limited data

TCEB1-mutated renal cell carcinoma, also renal cell carcinoma with TCEB1 mutation, is an evolving entity that is similar to clear cell renal cell carcinoma and clear cell tubulopapillary renal cell carcinoma.[1]

It should not be confused with TFEB renal cell carcinoma, also known as renal tumour with t(6;11) translocation.

General

  • Evolving entity.
  • TCEB1 (transcription elongation factor B, polypeptide 1) is part of a complex that binds with the product of the VHL gene;[2] thus, it acts as a tumour suppressor.
  • Good prognosis - based on limited data.[1]

Gross

  • Cystic changes.

Microscopic

Features:

  • Clear cells with abundant cytoplasm and basal nuclei.
    • Luminal nuclei (like in clear cell tubulopapillary RCC) may be seen.
  • Usually ISUP nucleolar grade 2.
  • Fibromuscular bands - key feature.

DDx:

Images

Morphology compatible

  • RCC CCFB - very low mag.

  • RCC CCFB - low mag.

  • RCC CCFB - intermed. mag.

  • RCC CCFB - high mag.

  • RCC CCFB - high mag.

  • RCC CCFB - very high mag.

IHC

Features:[1]

See also

References

  1. ↑ 1.0 1.1 1.2 Hakimi, AA.; Tickoo, SK.; Jacobsen, A.; Sarungbam, J.; Sfakianos, JP.; Sato, Y.; Morikawa, T.; Kume, H. et al. (Jun 2015). "TCEB1-mutated renal cell carcinoma: a distinct genomic and morphological subtype.". Mod Pathol 28 (6): 845-53. doi:10.1038/modpathol.2015.6. PMID 25676555.
  2. ↑ URL: http://www.omim.org/entry/600788. Accessed on: 12 June 2015.
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